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This paper examines the hidden challenges experienced by individuals with special needs during the transition years between school and work. An assessment framework is proposed that covers domains of difficulties, developmental tasks during the transition years, the matrix of support within the home-community-institutions ecosystems, and the individual’s personal profile of schooling experience, academic attainments, interests, aptitudes and sense of self-determination. The paper ends with a model for intervention addressing self-efficacy and the social cognitive environment of the individual.  相似文献   
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The alphasyllabary of Kannada comprises more than 400 symbols called akshara; each symbol is visuo-spatially complex with a consistent representation at the dual levels of the syllable and the phoneme. We investigated reading difficulties in Kannada among 8–12 year old children by conducting a between-groups followed by a case series analysis. We compared the children with reading difficulties with same age competent readers and younger readers who were similar in language level, matched on measures of vocabulary, syntactic processing, and morphological processing. Reading difficulties were characterized by poor akshara knowledge. Concomitant impairments were in syllable and phoneme level phonological skills, in rapid naming and in oral language skills. The case series analysis highlighted the variability of profiles among poor readers with the most common impairments being in akshara knowledge and phonological processing. Sub-groups of poor readers showed additional deficits in oral language, rapid naming, and visual processing skills. Together our findings indicate that the core deficit associated with reading difficulty in the alphasyllabary of Kannada is in the phonological domain. However, accompanying deficits in related skills, including visual processing, can further inhibit reading attainment. The findings from this study support a multifactorial model of reading development.  相似文献   
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The present study evaluated the cardioprotective potential of vitamin-E by studying its effect on hemodynamic parameters, lipid peroxidation, myocyte injury marker and ultrastructural changes in model of isoproterenol-induced myocardial necrosis in rats. Wistar albino male rats (150–200 g) were randomly divided into saline, ISP control, and vit E groups. Vitamin E group was administered vitamin E at a dose of 100mg/kg/day while saline and ISP control groups received saline orally for one month. On 29th and 30th day, ISP (85 mg/kg, sc) was administered at an interval of 24 h to vit E and ISP control rats. On 31st day, rats of all groups were anesthetized and hemodynamic parameters were recorded. At the end of experimentation, animals were sacrificed; hearts were excised and processed for biochemical and ultrastructural studies. ISP administration produced marked cardiac necrosis as evidenced by significant decrease in my ocardial creatine kinase-MB as well as increase in malonaldialdehyde levels. ISP-induced myocardial necrosis resulted in myocardial dysfunction as evidenced by significant depression in heart rate and mean arterial pressure in the ISP control group as compared to saline control. Salient ultrastructural changes including extensive loss of myofibrils, muscle necrosis, loss of mitochondria, and formation of several intracytoplasmic vacuoles and lipid droplets further confirmed the ISP-induced myocardial damage. However, subsequent to ISP challenge, vit E treatment significantly preserved the myocardium by restoring myocardial CK-MB activity, inhibiting the ISP-induced lipid peroxidation and ultrastructural changes. Additionally, pre-and co-treatment of vit E prevented the deleterious ultrastructural changes caused by ISP. These beneficial effects of chronic vit E treatment also translated into significant restoration of the altered hemodynamic parameters. The present study clearly demonstrated the cardioprotective potential of vit E at dose of 100 mg/kg in ISP-induced model of myocardial necrosis in rats. The significant restoration of altered hemodynamic parameters, myocardial CK-MB activity, prevention of ISP-induced rise in lipid peroxidation and ultrastructural changes may confirm its cardioprotective effect.  相似文献   
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Educational Studies in Mathematics - In India, a curriculum reform inspired by critical perspectives has sought to transform primary mathematics teaching and learning. It is aimed at strengthening...  相似文献   
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We report the associations between phonological awareness and orthographic knowledge in readers of alphasyllabic Kannada. Less fluent 9- to 12-year-olds with lower orthographic knowledge were at floor on phoneme tasks, but more fluent readers, with greater orthographic knowledge, showed significant phonemic awareness. Orthographic knowledge, phoneme awareness, and RAN were independent predictors of reading rate and, together with syllable awareness, predicted individual differences in reading accuracy. Taken together, we suggest that increasing alphasyllabic literacy promotes a dual representation at the syllable and phoneme level and that the analytic processes involved in acquiring orthographic knowledge and mappings with phonology are a universal aspect of reading development across languages.  相似文献   
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We explore how a firm’s knowledge structure characteristics and market identity—as reflected in its position in the industry value chain and market status—influence knowledge-based alliance (KBA) formation. We propose that a firm’s propensity to form KBAs is affected by the congruence (or misalignment) between its knowledge structure characteristics (i.e., knowledge depth and scope) and the role it plays in the industry, as demanded by its position in the value chain. We further argue that while a firm’s market status can amplify the positive effect of the congruence, thereby enhancing a firm’s proclivity to form KBAs, being prominent can also hurt a firm when it faces a misalignment between its knowledge structure characteristics and externally induced expectations related to its value chain position. We validate our arguments using panel data on 1051 firm-year observations for 197 firms patenting in the global fuel cell industry for the period 1999–2009. By developing a richer understanding of the relationship between a firm’s knowledge-based resources and KBA formation, we answer the call for a better understanding of how and when firms can leverage their internal knowledge configurations to improve their proclivity to form alliances.  相似文献   
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It is of great interest to determine the topological shape of the locus of solutions of any given set of polynomial equations. Answer to this geometrical question leads us to the interaction of topology, algebraic/analytic geometry and differential geometry.  相似文献   
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