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1.
Munzir M. E. Ahmed J. A. S. Al-Obosi H. M. Osman M. E. Shayoub 《Indian journal of clinical biochemistry : IJCB》2016,31(2):162-170
Acetaminophen (APAP) a commonly used drug for decrease the fever and pain but is capable to induced hepatotoxicity at over dose. This study was carried out to investigate the effect of APAP on the expression of anti-apoptotic and antioxidative defense genes, and whether aldose reductase over-expressing plasmid capable to protect against APAP-induced oxidative stress and cell death. APAP treatment induced oxidative stress and hepatotoxicity, and significantly increased aldose reductase mRNA and protein expression in mouse hepatocyte (AML-12). Unexpectedly, AML-12 cells over-expressing aldose reductase augmented APAP-induced reduction in cell viability, reactive oxygen species (ROS) production, glutathione (GSH) depletion and glutathione S-transferase A2 expression. Moreover, over-expression of aldose reductase potentiated APAP induced reduction on proliferating cell nuclear antigen, B cell lymphoma-extra large (bcl-xL), catalase, glutathione peroxidase-1 (GPx-1) and abolished APAP-induced B-cell lymphoma 2 (bcl-2) inductions. Further, over-expression of aldose reductase significantly abolished AMP activated protein kinase (AMPK) activity in APAP-treated cells and induced p53 expression. This results demonstrate that APAP induced toxicity in AML-12, increased aldose reductase expression, and over-expression of aldose reductase render this cell more susceptible to APAP induced oxidative stress and cell death, this probably due to inhibition AMPK or bcl-2 activity, or may due to competition between aldose reductase and glutathione reductase for NADPH. 相似文献
2.
This paper is a report of a survey conducted to determine teachers’ perception of the science laboratory learning environment and the relationship between different aspects of this environment and satisfaction from teaching and learning. Teachers’ perceptions of psychosocial aspects were measured by use of the Science Laboratory Environment Inventory (SLEI), whereas perceptions of physical aspects were measured by use of the Physical Science Laboratory Environment Inventory. The level of satisfaction was measured by use of a satisfaction scale (SC). Data were collected from 800 science teachers in secondary schools in Malaysia. Analysis of findings revealed that teachers have positive attitudes on all SLEI scales, with the exception of the open-ended scale. In terms of physical aspects, teachers regard lighting and technology as highly important but furniture and equipment, space, air quality and safety as of moderate importance only. Results also showed that teachers’ satisfaction from teaching in the laboratory was positive. Subsequent analysis revealed a significant predictive relationship between teachers’ perception of science laboratory learning environments and their teaching and learning satisfaction. 相似文献
3.
İlke Ali Gürses Ahmet Ertaş Başak Gürtekin Osman Coşkun Mehmet Üzel Özcan Gayretli Mehmet Selman Demirci 《Anatomical sciences education》2019,12(4):370-385
Little is known regarding the profiles of whole body donors in Muslim majority countries where donation is scarce. Therefore, this study aims to profile registered donors in Turkey by means of a survey. The explored data could be used to improve ongoing campaign efforts and ethical practices such as commemoration services. Registered donors of the donation programs at the two faculties of medicine of Istanbul University were compared with the national population and a cluster analysis was performed to reveal any concealed sub-groups. Data from 188 respondents were analyzed. The majority of registered donors were married (42%), male (65.4%), aged over 50 years (76%), held a tertiary education degree (49.7%), and were irreligious (58.5%). Cluster analysis revealed two groups with significantly different educational levels, marital statuses, and religious choices. Regarding whether their bodies could be used for education or research, the majority (64.5%) of the respondents left the decision to the anatomy department. Similarly, 73.8% approved indefinite use of their organs, body parts and/or skeletons. The respondents were also willing to share their medical history (94.2%) and personal information (81.6%) if needed. Motivational themes for body donation including usefulness, impermanence, religion, awareness, and kinship were devised after a thematic analysis. Among the respondents, 56.5% were registered organ donors and 63.3% were frequent blood donors. The results of this study provide data that may help revising informed consent forms, developing and implementing thanksgiving ceremonies, and selecting additional targets for supporting body donation campaign activities such as organ and blood donation units. 相似文献
4.
Osman Nafiz Kaya 《Research in Science Education》2008,38(1):91-110
Although researchers in higher education propose alternatives to traditional approaches to assessment, traditional methods
are commonly used in college or university science courses. The purpose of this study was to explore the feasibility and validity
of Prospective Science Teachers’ (PSTs) concept maps as authentic assessment tools in a student-centred approach to describe
the changes in the conceptual understanding of the PSTs in general chemistry laboratory investigations. After the PSTs (n = 47) decided on important issues, such as who would assess their concept maps and what scoring strategy and criteria would
be used, they practiced assessing their own and peers’ concept maps during the first five laboratory investigations. They
subsequently constructed and assessed pre- and post-laboratory concept maps in a student-centred approach consisting of self,
peer, and instructor assessments for the five remaining laboratory investigations. The results of the study showed using pre-
and post-laboratory concept maps as authentic assessment tools in a student-centred approach was valid and reliable for describing
the conceptual understanding of the PSTs in a university general chemistry laboratory course. The results of individual interviews
indicated most PSTs had positive views of their assessment practices in the laboratory course. This study also provides pedagogical
implications for the training of science teachers. 相似文献
5.
6.
Osman Birgin Mustafa Baloğlu Hakan Çatlıoğlu Ramazan Gürbüz 《Learning and individual differences》2010,20(6):654-658
The purpose of the present study is to investigate mathematics anxiety among 220 sixth through eighth grade Turkish students in terms of mathematics achievement levels, perceived enjoyment of the mathematics teaching method, perceived enjoyment of mathematics, and perceived help with mathematics from parents. The Mathematics Anxiety Scale for Primary School Students (Bindak, 2005) was used to assess the levels of mathematics anxiety. A 3 × 2 factorial analysis of variance results showed that there was not a significant interaction effect or main effect of gender; however, there was a significant main effect of grade level. Standard multiple regression analyses show that independent variables accounted for 63% to 70% of variability in the dependent variable. The results also indicate that not only the perceived enjoyment of mathematics, but also the enjoyment of the mathematics teaching method and help with mathematics from parents had a significant effect on mathematics anxiety. 相似文献
7.
Persisting difficulties in body procurement in Turkey led to the acquisition of donated, unclaimed, autopsied, and imported bodies regulated under current legislature. Yet, no study had investigated the extent of the on‐going cadaver problem. This study was aimed to outline cadaver sources in anatomy departments and their effectiveness by means of an online survey. Additionally, official websites of each department were investigated regarding any information on body donation. Unclaimed cadavers (84.8%) were the major source for anatomy departments, followed by donated (50%) and imported cadavers (39.1%). Foundation‐based medical faculties were more likely to import cadavers (P = 0.008). There was a moderate increase (rs = 0.567; P = 0.018) in donation registrations to our department after 2000. The departments in cities with significantly higher City‐Based Gross Domestic Product measures (US$9,900 vs. US$16,772, P = 0.041), frequencies for mid‐ or high‐school graduates (30.4% vs. 31.3%, P = 0.041), and frequencies for under‐ or post‐graduates (13.1% vs. 15.8%, P = 0.24) had managed to use donated cadavers. Anatomy departments’ major reasons for using unclaimed cadavers were education (45.9%), unclaimed cadavers being the only source (24.3%), and receiving inadequate donations (21.6%). Nine out of seventy‐four departments (12.2%) provided information regarding body donation on their websites. Body procurement remains as a serious problem in Turkey and it is apparent that current legislature does not provide a sufficient cadaver inflow. Similarly, anatomy departments’ effectiveness in public awareness of body donation and support in the National Body Donation Campaign seems questionable. Anat Sci Educ 11: 155–165. © 2017 American Association of Anatomists. 相似文献
8.
Magda Osman 《Learning and individual differences》2012,22(5):575-584
Monitoring refers to online awareness and self-evaluation of one's goal-directed actions, while Control refers to the generation and selection of goal-directed actions (Osman, 2010a). The present study examines the extent to which external estimations of performance influence monitoring and control behaviors. To achieve this, a complex dynamic decision making task was used in which three different cues were manipulated in order to control three outcomes. The experiment was divided into two conditions. The Externally guided-condition received information designed to influence people's evaluation of control performance, whereas the Self-guided-condition was not provided this information. The findings revealed that control performance differed according to whether the success of one's actions was evaluated against external or self-guided estimations of performance. This article proposes that Monitoring behaviors can strongly influence control behaviors and this is achieved according to the way in which outcomes of decisions are evaluated. Finally, with respect to adult learning, the findings from this study suggest that setting one's own goals do not lead to improvements in learning when the task is a complex one. 相似文献
9.
In introducing the special issue on Large Class Pedagogy: Opportunities and Challenges of Massification the present editorial takes stock of the emerging literature on this subject. We seek to contribute to the massificaiton debate by considering one result of it: large class teaching in higher education. Here we look to large classes as a problem in promoting student learning, quality education, and consequently as a challenge to socio-economic development. That said, whilst large classes do pose very specific challenges, they also hold promise and opportunities for innovation in support of student learning. Here we consider the contributions to this special issue from a cross section of disciplines and higher education environments. 相似文献
10.
Samia Satti Osman Mohamed Nour 《Minerva》2011,49(4):387-423
In this paper we discuss the interaction between science policies (and particularly in the area of scientific research) and
higher education policies in Gulf and Mediterranean Arab countries. Our analysis reveals a discrepancy between the two sub-regions
with respect to integration in the global market, cooperation in scientific research and international mobility of students.
The paper discusses the implications of the analysis of reform policies and higher education restructuring. 相似文献