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1.
Arvind Chandrasekaran Shanmugasundaram Pakkiriswami Jian Liang You Ashwin Acharya Muthukumaran Packirisamy Denis Maxwell 《Biomicrofluidics》2008,2(3)
90 kDa heat shock protein (HSP90) is a ubiquitous molecular chaperone and is one of the abundant proteins present in a cell under normal and stressed conditions. The adenosine triphosphate (ATP) binding region of HSP90 is currently under a great degree of study because of the interest of its role in cancer and protein maintenance; the binding of ATP to HSP90 induces a large conformational change in the protein as a result of the activity of different types of stressors within the cells. In the present paper, a simple microfluidic biosensor is proposed for the characterization of ATP-HSP90 interactions through the principle of bioresistive variation. The experimental results prove that the present biosensor system is highly suitable for the detection of heat shock proteins present in a real-time biological sample, which is very useful for in-situ biomedical applications and rapid pathogenic detections. 相似文献
2.
Parul Jain 《The Communication Review》2014,17(1):27-44
Using communication accommodation theory as a framework, this study explores and compares communication patterns of international medical graduate (IMG) physicians and United States medical graduate (USMG) physicians in intergroup, interpersonal, and intercultural context. Given that every fourth doctor practicing medicine in the U.S. is an internationally trained physician (AMA-IMG, 2010) an examination of the influence on patient-provider communication involving IMG physician and comparison with USMG physician is warranted. In a national survey of IMG and USMG physicians, the participants self-reported their perceptions of communication behaviors they used during a medical interaction. Although no difference was found between IMG and USMG physicians use of communication accommodation strategies during medical interaction, IMG physicians reported practicing significantly more relational communication than their U.S. counterparts. USMG physicians reported greater difficulty in communication owing to differences in culture than IMG physicians. Implication of findings for patient-centered communication, patient-physician relationship, and communication skills training is discussed. 相似文献
3.
Sushan Acharya 《Compare》2019,49(2):211-229
Functional adult literacy interventions have been regarded for many decades by policy makers as an effective way of imparting health knowledge. Supported by research on the statistical relationships between women’s literacy rates and health indicators, this dominant policy discourse is based on assumptions that non-literate women lack understanding and confidence, and that formal programmes and institutions constitute the main sites of learning. Proposing a broader conceptualisation of literacy as a social practice and of health as connected with social justice, this article draws on policy analysis and the authors’ earlier research in Nepal to re-examine the relationship between gender, literacy and health. By comparing health and literacy approaches used within the education and health sectors and taking account of new and indigenous informal learning practices, the article points to ways of investigating the complex interaction of factors that influence inequalities in gender and health at community level. 相似文献
4.
Parul Goel Nidhi Gupta Surjit Singh Ashish Bhalla Navneet Sharma K. D. Gill 《Indian journal of clinical biochemistry : IJCB》2012,27(1):34-39
Oximes such as pralidoxime chloride reactivate acetylcholinesterase. However their role in management of organophosphate poisoning
is controversial. The study was carried out to find effectiveness of pralidoxime chloride (2-PAM) in regenerating red cell
acetyl cholinesterase in first 24 h following administration of it in dose recommended by WHO. Eight patients with OPP [chlorpyriphos
(3), phorate (3), dichlorvos (1) and monocrotophos (1) who fulfilled the criteria for inclusion were investigated. In addition
to decontamination and atropine, all these patients were administered 30 mg/kg body wt of 2-PAM as bolus dose followed by
7.5 mg/kg body wt/h with maximum dose being 500 mg/h as continuous infusion till first 24 h. Red cell AChE activity was estimated
every 15 min for first 4 h, one hourly for next 4 h and then 2 hourly till 24 h and subsequently without 2-PAM every 12 h
till 7 days or discharge or death which ever earlier. In all the patients maximum increase in activity was observed in first
4 h following which rise was very slow despite continued 2-PAM infusion and reaching a steady state in 20 h in all the cases.
The increase in red cell AChE activity observed in diethyl group at 24 h of 2-PAM infusion was 154% vs. 81% in dimethyl group.
At 7 days the increase in activity was 215% vs. 118% respectively. However on multiple repeated ANOVA, no statistically significant
difference was observed between diethyl and dimethyl groups at admission and discharge (P > 0.05). Similarly no significant difference was observed in three groups when patients were categorized according to WHO
classification of organophosphates (P > 0.05). The maximum increase in red cell AChE activity occurs in first 4 h of 2-PAM administration followed by a slow increase
despite 2-PAM infusion till 24 h. 相似文献
5.
Anmol Goyal Rajendra Prasad Parul Goel Amit Pal Suvarna Prasad Isha Rani 《Indian journal of clinical biochemistry : IJCB》2021,36(4):387
Coronavirus disease 2019 (Covid-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pandemic disease which has affected more than 6.2 million people globally, with numbers mounting considerably daily. However, till date, no specific treatment modalities are available for Covid-19 and also not much information is known about this disease. Recent studies have revealed that SARS-CoV-2 infection is associated with the generation of thrombosis and coagulopathy. Fundamentally, it has been believed that a diverse array of signalling pathways might be responsible for the activation of coagulation cascade during SARS-CoV-2 infection. Henceforth, a detailed understanding of these probable underlying molecular mechanistic pathways causing thrombosis in Covid-19 disease deserves an urgent exploration. Therefore, in this review, the hypothetical crosstalk between distinct signalling pathways including apoptosis, inflammation, hypoxia and angiogenesis attributable for the commencement of thrombotic events during SARS-CoV-2 infection has been addressed which might further unravel promising therapeutic targets in Covid-19 disease. 相似文献
6.
In this paper, we reflect upon how dialogs and debates in a non-governmental organization (NGO) – CARE India in the context of a girls’ education project shaped staff members’ understandings of gender justice. As CARE India staff shared their experiences in the field, in the organization, and in domestic spaces during gender training sessions and other forums, their different politics in these spaces shaped how they translated global discourses of gender justice to produce fluid, contested, and contextual understandings. While these dialogs included the voices of diverse social actors in identifying the capabilities needed for gender justice in education, they were often reframed by local NGO actors. 相似文献
7.
Seema Bhargava Khageshwar Mahato Anjali Manocha Mamta Kankra Parul Singla Anisha Sharma Ashok Ahirwar Vinod Gupta Salamma Jose 《Indian journal of clinical biochemistry : IJCB》2021,36(3):360
HbA1c is used extensively for the diagnosis and management of diabetes mellitus. It constitutes 80% of glycated HbA1(Glycated haemoglobin(GHb)A), and depends upon blood glucose and RBC life span. RBC life span varies with anemia, leading to a consequent alteration in the HbA1c value irrespective of the circulating blood glucose concentration. But to the best of our knowledge no Hb cut offs have been derived for appropriate interpretation of HbA1c. The prevalence of anemia in Indian population is nearly 40% as per its definition by WHO—Hb < 12 g/dL in females and < 13 g/dL in males—with most cases attributable to nutritional deficiencies. Hence, we aimed to identify Hb cut-off for accurate interpretation of HbA1c in presence of deficiency anemias. Partial correlation between random blood glucose (RBG) and HbA1c was studied in 1312 subjects, 470 of whom had deficiency-related anemia]. The data was adjusted for age, sex and Hb. Partial correlation between RBG and HbA1c was highly significant (p < 0.0001) till Hb of 8.1 gm/dL. Significance reduced to p = 0.003 and p = 0.006 as the cut off of Hb reduced to 7.1 gm/dL and 5.0 gm/dL, respectively, but was not lost. Hence, caution in interpretation of HbA1c is not required till an Hb of 5 g/dL. 相似文献
8.
David Dennie Parul Acharya Deirdre Greer Camille Bryant 《Psychology in the schools》2019,56(5):765-780
The study examined the extent that teacher–student relationships (TSR) influenced basic psychological needs, engagement, and student growth using the self‐systems process model as a framework using structural equation modeling. Based on prior research, it was hypothesized that context (TSR) influenced self (basic psychological needs), which influenced action (engagement), and consequently, influenced outcome (student score and grade point average‐GPA). The findings of the study supported prior research that a TSR positively influenced levels of engagement in the classroom and, consequently, student outcomes as measured by classroom grade point average (GPA) and standardized assessment results. Using an identical methodological setup that substituted student growth percentiles (SGP) for scale scores, it was determined that TSR, basic psychological need satisfaction, and level of engagement do not influence SGP. Implications and potential contributions are discussed. 相似文献
9.
Munjal M. Acharya Surbhi H. Khamesra Surendra S. Katyare 《Indian journal of clinical biochemistry : IJCB》2005,20(1):56-60
The effect of picrotoxin-induced convulsions on lysosomal function in rat brain were evaluated by measuring the free as well
as total acid phosphatase, cathepsin D, acid ribonuclease (RNAse II) and acid deoxyribonuclease (DNAse II) activities. Following
picrotoxin treatment the free RNAse II activity increased whereas the total activities of practically all the other enzymes
decreased. Paradoxically, the cathepsin D activity, free as well the total was completely abolished. In case of all the enzymes
the ratio of Total activity/Free activity decreased indicating increased lysosomal membrane fragility which could lead to
process of neurodegeneration in the epileptic animals. 相似文献
10.
Upma Garg Anju Jain Parul Singla Sarita Beri Rajiv Garg Arvind Saili 《Indian journal of clinical biochemistry : IJCB》2012,27(2):196-199
Retinopathy of prematurity (ROP) is a major cause of blindness in children. Free radicals are implicated in the development of this retinopathy. We studied the role of free radicals in ROP and enrolled 60 preterm neonates at 30–32 weeks age. Thirty neonates predisposed to development of ROP, were placed in study group and 30 normal neonates in control group. Malondialdehyde and antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPX) were measured in blood spectrophotometrically. Both the groups were followed-up to 40–42 weeks age. Serum MDA levels, erythrocyte SOD and plasma GPX were significantly high in study group at 30–32 weeks as compared to control group. At follow up visit significant increase in MDA level and decrease in SOD and GPX level among the study group was seen. This disturbance in equilibrium of oxidant and antioxidant status initiates an inflammatory process in retinal tissue leading to development of ROP. 相似文献