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Rathore SS Agarwal SK Pande S Singh SK Mittal T Mittal B 《Indian journal of clinical biochemistry : IJCB》2011,26(3):222-229
Coumarinic oral-anticoagulants (COAs) are commonly used for treatment of thromboembolic events. However, these medications
have a narrow therapeutic range and there are large inter-individual variations in drug response. This is especially important
in the initial phases of oral-anticoagulant therapy. Recent advancements in pharmacogenetics have established that clinical
outcomes in oral-anticoagulant therapy are affected by genetic factors. The allelic variants of genes like cytochrome P450
2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1) are closely associated with maintenance dose of oral
anti-coagulants. In addition, GGCX (Gamma-glutamyl carboxylase) polymorphism at position 12970 (rs11676382), CYP4F2 (rs2108622;
V433M; 1347 C > T) and Apolipoprotein E (APOE) variants have been shown to explain a small but significant influence on dose
requirements. There are large differences in the frequencies of these polymorphisms between different world populations which
are also related to the requirements of oral anticoagulants. However, the final drug dosage in an individual is determined
by complex sets of genetic and environmental factors and several dosing algorithms which combine clinical and genetic parameters
to predict therapeutic COA doses have also been developed. The algorithm based dose prediction shows the importance of pharmacogenetic
testing in patients undergoing oral anticoagulant therapies. 相似文献
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INTRODUCTION In typical video transmission systems, a video signal is compressed, and the resulting bit stream is transmitted over an error-prone channel. The errors may consist of symbol errors caused by fading, as observed for wireless channels, or packet erasures caused by congestion, as observed in the Internet. If a received video packet contains errors, then the portion of the video signal contained in the packet is lost and must be concealed. Error concealment schemes alone cannot … 相似文献
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