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Herman S D'Souza Geraldine Menezes T Venkatesh 《Indian journal of clinical biochemistry : IJCB》2002,17(1):1-4
Our study aimed at comparing lead and zinc protoporphyrin (ZPP) levels in capillary and venous blood samples in a small population
and to employ an easier method of sample collection for a major screening program in school children in major Indian cities.
An awareness program on lead and its effects was conducted in two different schools. A total of thirty urban school children
from South India, with an age group between 4–12 years consented for dual blood sampling and reported for the study. Venous
and capillary blood samples were obtained simultaneously. Blood lead and zinc protoporphyrin (ZPP) levels were estimated using
ESA Lead Analyzer and Haematofluorometer respectively. A significant correlation between capillary and venous ZPP (r=0.98)
and lead (r=0.99) was observed. Rank sum test showed that there is no statistically significant difference between capillary
and venous ZPP (P=0.891) and lead (P=0.672) values. This pilot study recommends that screening for lead may be done using
capillary blood samples since significant correlation is observed between capillary and venous blood measurements. Obtaining
samples using this mode is a non-invasive, less expensive, quick and easy method in children. Appropriately performed capillary
sampling may be considered as an acceptable alternative to venipuncture for screening of blood for lead poisoning both in
children and adults. 相似文献
3.
Sanjeev Shruthi Molly Mary Thabah Bobby Zachariah Vir Singh Negi 《Indian journal of clinical biochemistry : IJCB》2021,36(2):185
To study oxidative stress in systemic lupus erythematosus (SLE) by estimating serum oxidised LDL (OxLDL), 8-hydroxy-2′-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and total anti-oxidant status and to correlate with SLE disease activity and disease damage. Eighty SLE patients satisfying the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) 2012 criteria and 80 healthy controls were studied. Exclusion criteria were infections, renal insufficiency, other connective tissue diseases, drug-induced lupus, smoking, alcohol consumption. Disease activity was measured by SLE disease activity index-2 K (SLEDAI), disease damage was quantified by SLICC-Damage Index (SDI). Sera was tested for OxLDL, 8-OHdG, and total antioxidant status (TAS) by double-antibody sandwich ELISA; MDA measured by Colorimetric assay. Oxidative stress markers were compared between group1- controls, group 2-mildly active SLE (SLEDAI ≤ 5), group 3- moderate to highly active SLE (SLEDAI ≥ 6). SLE patients had significantly higher MDA, 8-OHdG and lower TAS when compared to healthy controls, while OxLDL was similar in the three groups. MDA, 8-OHdG were significantly higher, TAS lower in group 3 compared to group 2. MDA had positive correlation with SLEDAI, TAS negatively correlated with SLEDAI. SLE with neuropsychiatric manifestations, vasculitis, anti-sdDNA antibodies had higher MDA, MDA/TAS ratio. SLE patients with thrombocytopenia, and vasculitis had higher OxLDL. Only OxLDL was significantly higher in those patients who have SDI > 1. SLE patients have increased oxidative stress measured by increases in MDA, 8-OHdG, and lower total antioxidant status that was associated with disease activity and some disease manifestations. However only OxLDL was associated with damage. 相似文献
4.
Understanding disease transmission is a complex problem highlighted by the COVID-19 pandemic. These studies test whether 3- to 6-year-old children in the United States use information about social interactions to predict disease transmission. Before and during COVID-19, children predicted illness would spread through close interactions. Older children outperformed younger children with no associations between task performance and pandemic experience. Children did not predict that being hungry or tired would similarly spread through close interactions. Participants include 196 three- to six-year-olds (53% girls, 47% boys; 68% White, 9% Black, 7% Asian, 6% Hispanic or Latinx), with medium-sized effects (d = .6, = .3). These findings suggest that thinking about social interaction supports young children's predictions about illness, with noted limitations regarding children's real-world avoidance of disease-spreading behaviors. 相似文献
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Sultana Furruqh D. Anitha T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2004,19(2):72-79
Reference intervals in clinical chemistry are commonly based on results of measurements in reference western population or
are taken from the western literature. Reference Values are thought to aid physicians to interpret results of measurements
and, should be representative of a defined group of individuals. This group should be as similar as possible to the patients
under investigation. The reference population in this, study has been recruited from the individuals attending the Health
Plan Clinic who fulfill the defined inclusion and exclusion criteria as well as defined partition criteria. The samples were
sorted based on the decision by the physician. The emerging group of individuals was considered as a reference population
for the hospital patients and the results of measurements in this study was evaluated statistically, to stress on the urgent
need to establish the in-house reference values. The reference limits are defined as the central 95 percentile of the population
after eliminating the outliers. The lower, reference limit is the 2.5 percentile while the upper reference limit constituted
the 97.5 percentile for the population. 相似文献
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Anita R. Bijoor S. Geetha T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2004,19(2):20-22
Malabsorption syndromes causing steatorrhoea are quite common in India. Estimation of faecal fat is an important non-invasive
investigation, which provides vital information regarding the occurrence of malabsorption. The aim of this study was to estimate
the fat excretion per day in stools of apparently healthy adults on an unrestricted diet in random spot stool samples using
the Acid Steatocrit Method, which provides an alternate, simpler and yet reliable method of stool fat estimation. Several
studies have proved the correlation of the acid steatocrit method with the conventional methods. In India, however, there
has been no published data regarding the normal levels of fat in the stools, by the acid steatocrit method. We follow the
normal range values, as set by the United States and the European countries, not having a range for the Indian population.
Hence, we took up a preliminary study, to estimate stool fat in a section of normal and healthy Indian population. The result
obtained after screening 600 healthy and normal adults, showed the mean of stool fat to be 8.72 gms/24 hours, which is much
higher than that, defined by Western literature (7 gms/24 hours). This can be accounted for, by the cultural and ethnic variations
in dietary and food habits. Further studies are required in the same direction, involving larger population groups, and in
different malabsorptive conditions. 相似文献
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Raviraja A Vishal Babu GN Sehgal A Saper RB Jayawardene I Amarasiriwardena CJ Venkatesh T 《Indian journal of clinical biochemistry : IJCB》2010,25(3):326-329
Ayurveda is a traditional form of medicine used by majority of the Indians. Here we report three cases of lead toxicity, following
intake of Ayurvedic medicines. Three patients presented with blood lead levels (BLLs) of 122.4, 115 and 42.8 μg/dl respectively
at the time of hospitalization. The first case was chelated with D- penicillamine, the second with calcium disodium ethylene
diamino tetra acetate (EDTA) and the third with environmental intervention and education. Associated Ayurvedic products were
collected from patients and analyzed for metallic concentration. Cessation of Ayurvedic medication along with chelation, nutritional
intervention and education, reduced the BLL to 27.4 μg/dl in the first case after 1 year, 21.1 μg/dl after 9 months in the
second and 18.2 μg/dl after 6 months in the third case. 相似文献
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A. Ravi Raja G. N. Vishal Babu Geraldine Menezes T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2008,23(2):200-203
Awareness about the toxic effects of non-essential metals is still lacking in developing countries. Lead is one among them,
which ranks second in the Agency for Toxic Substances and Disease Registry’ s top 20 lists of toxic metals. Some of the herbal
medicines prepared from certain roots and leaves are known to contain this toxic metal at alarming levels. We have a case
of a person who suffered from the toxic effects of lead such as vomiting and colicky abdominal pain after consuming a herbal
remedy for Jaundice treatment. This went unrecognized initially because of the presence of multiple problems like Malaria
and Renal calculi. Lead poisoning as causative factor for anemia, vomiting and colic were confirmed only when blood lead concentration
was estimated. A combination of chelation therapy and nutritional supplementation was found to be useful in reducing the body
lead burden. 相似文献
10.
Alpha-1-antitrypsin deficiency is a hereditary disease leading to hepatitis and cirrhosis. It is the most common genetic cause
of liver disease in children which must inherit the tendency from both parents to develop. It acquires the highest priority
in the differential diagnosis in a child with chronic liver disease. In this case report we substantiate the role of serum
protein electrophoresis, in diagnosing alpha-1-antitrypsin deficiency. 相似文献