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1.
Sonika Gupta Niraj Shende Swati Banerjee Satish Kumar M. V. R. Reddy Bhaskar C. Harinath 《Indian journal of clinical biochemistry : IJCB》2002,17(1):5-8
Tuberculosis remains major health problem in India and developing countries Immunodiagnosis has important role in screening,
diagnosis and management of tuberculosis. SEVA TB ES-31 antigen has shown potential in detecting tuberculous IgG antibody
in earlier studies from our laboratory. In the present study we have analysedSEVA TB ES-31 antigen specific immunoglobulinsIgM, IgA and IgG in clinically and bacteriologically confirmed pulmonary tuberculosis cases to determine the usefulness of specific immunoglobulin
class in the diagnosis of patients attending the hospital.
Of the 30 cases of pulmonary tuberculosis 25 (83.3%) were positive for IgG, 19 (63.3%) for IgM and 16 (53.3%) for IgA. On
combining IgG and IgM positivity, sensitivity was increased to 93.3%. While combining IgG and IgA positivity, sensitivity
increased to 90%. However specificity was decreased to 66.6% and 70% for both of these combinations respectively. It could
be envisaged from this study that IgG antibody detection against ES-31 antigen showed acceptable sensitivity (83.3%) and specificity
(86.6%) compared to IgM or IgA alone or in combination. When immune responses were analysed according to degree of sputum
positivity, IgG response was observed to be predominant in all grades, compared to IgM or IgA antibody. The addition of IgM
or IgA as an adjunct test increases the sensitivity but at the cost of specificity. Hence the detection of IgG alone is more
useful compared to IgM or IgA assay, in detecting tuberculosis disease cases coming to the hospital. 相似文献
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A. Sai Sabitha Deepti Mehrotra Abhay Bansal B. K. Sharma 《Education and Information Technologies》2016,21(6):1753-1767
Open educational resources (OER) are digitised material freely available to the students and self learners. Many institutions had initiated in incorporating these OERs in their higher educational system, to improve the quality of teaching and learning. These resources promotes individualised study, collaborative learning. If they are coupled with Learning Objects of Learning Management System (LMS), they can lead to opportunities for further pedagogical innovation. It has become increasingly important for educational institutions to support these resources, in a planned and systematic manner. Adapt, assemble and conceptualise existing OERs to respond to diverse learning needs of students and support a variety of learning approaches for a given learning goal is a challenge. In this work, convergence of OERs with Learning Objects is done through metadata using classification techniques. Localisation of these high quality learning materials with the learning content of LMS, delivered as a single instructional unit may help in greater knowledge delivery and this can satisfy the learning needs of diverse student. 相似文献
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Ramesh Chandra Ritu Aneja Charu Rewal Swati Bhowmik Sujata K. Dass Ritu Jain 《Indian journal of clinical biochemistry : IJCB》2000,15(2):141-147
In the current study, we report perturbations in hepatic, renal and splenic heme synthesis at the level of the rate limiting
enzyme, δ-amino levulinic acid synthase (ALA-S) on ethanol administration independently and in conjunction with iron-protoporphyrin
(FePP) in male Wistar rats. Excessive ethanol administration (5 ml/kg bw) resulted in a significant induction of hepatic,
splenic and renal ALA-S activity. Simultaneous administration of FePP (50 μmol/kg bw) reverted the observed induction response
to a sharp decline. The features of the action of ethanol and FePP togetherin vivo, i.e. a substantial inhibition of ALA-S is suggestive of the beneficial effects of this formulation in acute attacks of porphyria. 相似文献
5.
Chavan VU Durgawale PP Sayyed AK Sontakke AV Attar NR Patel SB Patil SR Nilakhe SD 《Indian journal of clinical biochemistry : IJCB》2011,26(3):283-289
Twenty-four hour urinary albumin excretion (UAE) is considered as gold standard method for albuminuria measurement, but collection
of 24-h urine is inconvenient. The aim of present study was to evaluate whether albumin: creatinine ratio (ACR) and urinary
albumin concentration (UAC) in different spot urine samples correlate or not with 24-h UAE for screening of microalbuminuria
in type 2 diabetic patients. We collected first morning void (FMV), random urine sample (RUS) and 24-h urine, separately on
consecutive days from 104 type 2 diabetic patients. ACR and UAC in each spot urine sample compared with 24-h UAE with regard
to Pearson correlation coefficient. Pearson’s correlation of albumin: creatinine ratio (ACR) with 24-h UAE was (r = 0.802 and 0.623) in first morning void (FMV) and random urine sample (RUS), respectively. Pearson’s correlation coefficient
of urinary albumin concentration (UAC) compared with 24-h UAE was (r = 0.943 and 0.920), in FMV and RUS, respectively, P < 0.01. Results revealed that values in first morning void (FMV) were better correlated with 24-h urinary albumin excretion
(UAE), than the values in random urine sample (RUS). We conclude that the first morning void (FMV) may be able to replace
24-h urine collection, preferably urinary albumin concentration (UAC) in the initial screening of microalbuminuria in diabetic
patients. 相似文献
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E. Raji Nair Swati Banerjee Satish Kumar M. V. R. Reddy B. C. Harinath 《Indian journal of clinical biochemistry : IJCB》2001,16(1):132-135
Proteins secreted into the culture medium byMycobacterium tuberculosis (M. tb) are shown to be source of antigens of immunodiagnostic interest. Anin vitro released 31 kDa antigen ESAS-7F isolated fromM.tb H37Ra culture filtrate by salt precipitation, SDS-PAGE and cation exchange fast protein liquid chromatography (FPLC) was shown
earlier to be a diagnostically important antigen fraction. In this report, we describe the isolation of ESAS-7F antigen using
monospecific antibody coupled to sepharose CL-4B column. The percentage recovery of ESAS-7F antigen using affinity chromatography
was approximately 8% of the total ES antigen proteins compared to 0.05% obtained by conventional purification steps using
salt precipitation, SDS-PAGE and FPLC. Similar seroreactivity was observed by the antigen isolated by both the methods in
indirect ELISA. Affinity chromatography helped in an increased recovery of ESAS-7F antigen and obviates the need for time
consuming conventional purification steps. 相似文献
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首先我必须对国际开放与远程教育理事会及其这次论坛的组织者表示最诚挚的谢意,感谢他们邀请我作这次演讲。虽然我感受到邀请是莫大的荣誉,但是必须承认我深感窘迫,尤其是今天要在与会的开放与远程教学领域的中坚人物面前发言就更是如此。我也许是国际开放与远程教育理事会中资格最浅的会员,也是第一次出席这次国际会议,但是我期待在未来的岁月里将有更多的机会出席这样的会议。 相似文献
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Santosh Mehrotra 《Prospects》2014,44(2):267-277
In the first decade of this century, India became one of the world’s fastest growing large economies, and began to face serious skill-related shortages of workers. Its TVET system has not responded adequately to the growth in demand for semi-skilled and skilled workers. This article describes six sets of reforms that India’s educational planners and policy-makers must put into place if these shortages are not to constrain India’s ability to benefit from the demographic dividend. 相似文献
9.
Margery K. Anderson Laura S. Tenenbaum Swati B. Ramadorai Debra L. Yourick 《Mentoring & Tutoring: Partnership in Learning》2013,21(2):116-132
The near-peer mentor model provides undergraduates and recent post-baccalaureates in the science, technology, engineering, and mathematics (STEM) fields with an internship in two related disciplines, STEM research and STEM education. The near-peer mentor is both a mentored research intern and a mentor to pre-college students. During the 2013 summer, 43 near-peer mentors from seven sites reported on the benefits, challenges, and personal development they experienced during the internship. In addition, 1,328 pre-college students reported their perceptions of near-peer mentors. In this qualitative study, we indicate that learning by being mentored, while simultaneously acquiring the abilities to mentor and teach, is an effective model for promoting career advancement and the psychosocial support associated with the acquisition of professional behaviors. 相似文献
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Faculty at 4-year colleges and other universities that have teaching as their primary focus are an important potential resource for conducting research on the psychology of aging and for training undergraduates who can fill the ranks as the next generation of researchers. This special-theme issue presents 9 articles that describe the components of a successful training program for faculty at these institutions; examples of student involvement in National Institute on Aging (NIA)-funded research being carried out at 6 institutions; the reflections of distinguished scholars who served as program faculty; and information on applying for the NIA's R15 Academic Research Enhancement Award. 相似文献