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G N Ramachandran made several remarkable contributions to biophysics and structural biology over the course of his celebrated career. In a pair of seminal papers in 1971, he also laid the foundation for the technique of ‘Projection Reconstruction’ that has come to revolutionize medical imaging. It is now routinely employed in modern CT (Computed Tomography) and MRI (Magnetic Resonance Imaging) scans. In this article, we review the salient features of this technique, that allows the ‘reconstruction of an object from its shadows’. 相似文献
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Anuradha Bharosay Vivek V. Bharosay Debapriya Bandyopadhyay Ajoy Sodani Meena Varma Haren Baruah 《Indian journal of clinical biochemistry : IJCB》2014,29(3):372-376
Stroke is the third major cause of death worldwide. Elevated plasma concentration of low density lipoproteins and low plasma concentration of high density lipoprotein concentration are associated with an increased risk of atherosclerosis and coronary heart disease but the relation between serum lipids, and cerebrovascular disease is less clear. The aim of this study was to investigate the reliability and accuracy of serum lipid profile in assessing the prognosis/neurological worsening in patients with ischemic and hemorrhagic cerebrovascular stroke. The subjects in the present study comprised of 101 healthy controls and 150 cerebrovascular stroke patients (including 90 with ischemic stroke and 60 with intracerebral hemorrhagic stroke). In both the groups fasting lipid profile was determined within 72 h of the stroke. A statistically significant association was observed (p < 0.001) between the parameters of lipid profile of cases and healthy controls, and also with the prognosis of the stroke. 相似文献
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Anuradha Bharosay Vivek Vikram Bharosay Meena Varma Kiran Saxena Ajoy Sodani Ravi Saxena 《Indian journal of clinical biochemistry : IJCB》2012,27(2):186-190
Stroke is the third major cause of death and foremost cause of disability worldwide. Cerebrovascular stroke remains largely a clinical diagnosis. The use of biomarkers in diagnosing stroke and assessing prognosis is an emerging and rapidly evolving field. The study aimed to investigate the predictive value of neurobiochemical marker of brain damage (neuron-specific enolase [NSE]) with respect to degree of disability at the time of admission and neurological worsening in acute ischemic stroke patients. We investigated 150 patients with cerebrovascular stroke who were admitted within 72 h of onset of stroke in the Department of Neurology at SAIMS. Venous blood samples were taken after admission and NSE was analyzed by solid enzyme linked immunosorbent assay using Analyzer and microplate reader from Biored: Code 680. In all patients, the neurological status was evaluated by a standardized neurological examination and the National Institutes of Health Stroke Scale on admission and on day 7. Serum NSE concentration was found to significantly correlate with both degree of disability and neurological worsening in acute ischemic stroke cases in the present study. The maximum serum NSE level within 72 h of admission was significantly higher in patients with greater degree of disability at the time of admission. Serum NSE levels were also found to be significantly elevated in patients with bad neurological outcome. Our study showed that serum NSE has high predictive value for determining severity and early neurobehavioral outcome after acute stroke. 相似文献
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