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In healthcare practice, the sedimentation rate of red blood cells (erythrocytes) is a widely used clinical parameter for screening of several ailments such as stroke, infectious diseases, and malignancy. In a traditional pathological setting, the total time taken for evaluating this parameter varies typically from 1 to 2 h. Furthermore, the volume of human blood to be drawn for each test, following a gold standard laboratory technique (alternatively known as the Westergren method), varies from 4 to 5 ml. Circumventing the above constraints, here we propose a rapid (∼1 min) and highly energy efficient method for the simultaneous determination of hematocrit and erythrocyte sedimentation rate (ESR) on a microfluidic chip, deploying electrically driven spreading of a tiny drop of blood sample (∼8 μl). Our unique approach estimates these parameters by correlating the same with the time taken by the droplet to spread over a given radius, reproducing the results from more elaborate laboratory settings to a satisfactory extent. Our novel methodology is equally applicable for determining higher ranges of ESR such as high concentration of bilirubin and samples corresponding to patients with anemia and patients with some severe inflammation. Furthermore, the minimal fabrication steps involved in the process, along with the rapidity and inexpensiveness of the test, render the suitability of the strategy in extreme point-of-care settings. 相似文献
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Rajarshi Sarkar 《Indian journal of clinical biochemistry : IJCB》2014,29(2):189-195
Although 3rd generation TSH assays are the most widely used immunoassays, credible comparison studies, specially involving Indian sub-populations are practically non-existent. To compare the TSH measurements between chemiluminescence (Architect) and electrochemiluminescence (Cobas) inmmunoassays in an urban ambulatory Indian population. 1,615 subjects were selected randomly from the usual laboratory workflow, their TSH measured in Architect and Cobas and the paired data thus generated were statistically analysed. TSH values of Cobas were observed to be higher than the Architect values by 28.7 %, with a significant proportional difference between the two, but majority of the Cobas values (above 90 %) were within the limits of agreement with Architect values. In situations where both the instruments are in use simultaneously, a standardization of the methods is imperative, in larger interest of the patient populace. 相似文献
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In this paper, we present a movement-based assay to observe adaptability in Caenorhabditis elegans locomotion behavior. The assay comprises a series of sinusoidal microchannels with a fixed wavelength and modulating (increasing or decreasing) amplitude. The channel width is comparable to the body diameter of the organism. Worms are allowed to enter the channel from the input port and migrate toward the output port. Within channel sections that closely match the worm's natural undulations, the worm movement is relatively quick and steady. As the channel amplitude increases or decreases along the device, the worm faces difficulty in generating the propulsive thrust, begins to slow down and eventually fails to move forward. A set of locomotion parameters (i.e., average forward velocity, number and duration of stops, range of contact angle, and cut-off region) is defined for worm locomotion in modulated sinusoidal channels and extracted from the recorded videos. The device is tested on wild-type C. elegans (N2) and two mutants (lev-8 and unc-38). We anticipate this passive, movement-based assay can be used to screen nematodes showing difference in locomotion phenotype. 相似文献
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The quality of evaluation of essay type answer books involving multiple evaluators for courses with large number of enrollments is likely to be affected due to heterogeneity in experience, expertise and maturity of evaluators. In this paper, we present a strategy to detect anomalies in evaluation of essay type answers by multiple evaluators based on the relationship between marks/grades awarded and symbolic markers, opinionated words recorded in answer books during evaluation. Our strategy is based on the results of our survey with evaluators, analysis of large number of essay type evaluated answer books and our own experiences regarding grievances of students regarding marks/grades. Results of both survey and analysis of evaluated answer books identified underline, tick and cross as frequently used markers compared to circle and question mark. Further, both opinionated words and symbolic markers identified through the survey are used by evaluators to express either positive or negative sentiments. They have differential usage pattern of these symbols as single evaluator and as one amongst multiple evaluators. Tick and cross have well define purposes and have strong correlation with marks awarded. However, the underline marker is being used for dual purpose of expressing both correctness and incorrectness of answers. Our strategy of inconsistency detection first identifies outliers based on the relationship between marks/grades awarded and number of symbols and/or opinionated words used in evaluation. Subsequently, marks and number of symbolic markers of outliers are compared with peer non-outlier answer books having same marks but different number of markers used. Such outlier answer books are termed as anomalous. We discovered 36 anomalies out of total 425 evaluated answer books. We have developed a prototype tool to facilitate online evaluation of answer book and to proactively alert evaluators of possible anomalies. 相似文献
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Quality in Inclusive Preschool Classrooms 总被引：1，自引：1，他引：0
Linda L. Hestenes Deborah J. Cassidy Jonghee Shim Archana V. Hegde 《Early education and development》2013,24(4):519-540
Research Findings: Quality of care for preschool children in inclusive and noninclusive classrooms was examined in two studies. In Study 1, comparisons across a large sample of classrooms (N = 1, 313) showed that inclusive classrooms were higher than noninclusive classrooms in global quality as well as on two dimensions of quality (Activities/Materials and Language/Interactions). In Study 2, a more diverse sample of 44 classrooms (20 inclusive and 24 noninclusive) did not reveal differences on the global measures of quality but did show a difference on a measure of teacher–child interactions. Teachers in inclusive classrooms had higher quality and more appropriate interactions with all children than did teachers from noninclusive classrooms. Ratings of perceived severity of children's disabilities were not related to any of the measures of classroom quality in either study. Practice or Policy: Both studies suggest that including children with disabilities in regular preschool classrooms does not result in lower quality programs or in less adequate teacher–child interactions, particularly for children with mild to moderate disabilities. Results illustrate the importance of continued education for early childhood professionals on high-quality teacher–child interactions. Faculty in personnel preparation programs as well as policymakers need to continue to promote high-quality interactions between teachers and children. 相似文献
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In this article, we discuss at length a combinatorial problem which has been of historic interest. It has appeared as a puzzle in several different versions with varying degrees of difficulty. It can be simply stated as follows: We are given a number of coins which are otherwise identical except that there may be at most one fake coin among them which is either slightly heavier or slightly lighter than the other genuine coins. Using only a two-pan weighing balance, we must devise a weighing scheme to identify the counterfeit coin and determine whether it is heavier or lighter (or declare that all coins are normal). We construct both sequential and non-sequential (that is, simultaneously declared) weighing plans for any given number of coins containing at most one fake coin using the minimum number of weighings needed. 相似文献
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