The origin and direction of industrial R&D in India     

Ashok V. Desai 《Research Policy》1980,9(1):74-96

This paper surveys the trends in industrial R&D in India over the last two decades. It shows that there has been a rapid rise in R&D expenditure and a shift in its composition towards in-house corporate R&D and away from R&D in government laboratories, which is explained by the laboratories' lack of market orientation and manufacturing experience. According to cross-section studies of corporate R&D, larger companies aim towards larger technological advances and take a longer view; but the overall composition of corporate R&D shows no discernible change. This apparent inconsistency is explained by the development of the technology market. Much R&D was triggered off by the need for import replacement arising from import controls till 1965 and later by the need for product diversification in the recession. But construction of new plants and mechanization for speeding up operations, activities where sustained R&D can yield large firms a steady flow of innovations, were unimportant or infrequent, and the demand for technology they gave rise to was largely met by imports.  相似文献   

Bancroftian filariasis in south east Madhya Pradesh: Pre-control epidemilogical observations     

Vandana Dixit  Ashok V. Kurup  A K Gupta  O M Kataria  G B K S Prasad 《Indian journal of clinical biochemistry : IJCB》1997,12(1):39-43

Lymphatic filariasis caused byWuchereria bancrofti is a major health problem next only to malaria. A study had been conducted to estimate the prevalence of microfilaraemia in a rural endemic community near Raipur. The incidence of microfilaramia in the community was found to be about 14% when studied by night finger prick method. The incidence appears to be more in males as compared to females. The infection rate in vector population i.e.,Culex quinquefasciatus was recorded at a rate of 10%. No relationship could be drawn between the rates of vector and human filarial infections or between the density of vector population and the rate of vector/human infection(s). Prior health education is essential before taking up control and preventive measures in given endemic zone.  相似文献   

Medicinal plants for treatment of diabetes mellitus     

R. Shukia  S. B. Sharma  D. Puri  K. M. Prabhu  P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》2000,15(1):169-177

Many plants have been used for the treatment of diabetes mellitus in Indian system of medicine and in other ancient systems of the world. Out of these only a few have been evaluated as per modern system of medicine. From many such plants only extracts have been prepared and their usefulness evaluated in experimental diabetes in animals. In some plants likeAllium cepa, Allium sativum, Ficus bengalensis, Gymnema sylvestre, Pterocarpus marsupium etc. active hypoglycemic principles have been isolated and their mechanism of action studied. Most of them seem to act directly on pancreas (pancreatic effect) and stimulate insulin level in blood. Some have extra pancreatic effect also by acting directly on tissues like liver, muscle etc. and alter favourably the activities of the regulatory enzymes of glycolysis, gluconeogenesis and other pathways. Since the plant products have less side effects, they have the potential as good hypoglycemic drugs. They may also provide clues for the development of new and better oral drugs for diabetes.  相似文献   

Mechanism of Antidiabetic Action of Compound GII Purified from Fenugreek (<Emphasis Type="Italic">Trigonella foenum graecum</Emphasis>) Seeds     

D. Puri  K. M. Prabhu  G. Dev  S. Agarwal  P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》2011,26(4):335-346

To study the mechanism of action of water soluble compound GII purified from fenugreek (Trigonella foenum graecum) seeds which was shown earlier to have antidiabetic effect in the subdiabetic, moderately and severely diabetic rabbits. In rabbits (1–1.5 kg bw) diabetes was induced by intravenous injection of 80 mg/kg bw of alloxan. They were fed with GII at a dose of 50 mg/kg bw daily once in the morning for 15 days in the subdiabetic and moderately diabetic and 30 days in the severely diabetic rabbits. Serum total cholesterol (TC), triglycerides (TG), LDL + VLDL cholesterol [(LDL + VLDL)C], HDL cholesterol [(HDL)C], total tissue lipids, glycogen and enzymes of carbohydrate metabolism (glycolysis, gluconeogenesis, polyol pathway) hexokinase, glucokinase, pyruvate kinase, malic enzyme, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, aldose reductase and sorbitol dehydrogenase and antioxidant enzymes glutathione peroxidase, glutathione reductase and superoxide dismutase were estimated. Liver and kidney function parameters were also estimated. Treatment with GII for 15 days in the subdiabetic and moderately diabetic rabbits and for 30 days in the severely diabetic rabbits (i) decreased the elevated lipids TC, TG, (LDL + VLDL)C and increased the decreased (HDL)C, (ii) decreased the elevated liver and heart total lipids, TC and TG, (iii) increased the decreased liver and muscle glycogen, (iv) increased the decreased hexokinase, glucokinase, pyruvate kinase, malic enzyme, glucose-6-phosphate dehydrogenase, superoxide dismutase, glutathione peroxidase, (v) decreased the increased glucose-6-phosphatase, sorbitol dehydrogenase, aldose reductase. Results thus show that treatment with GII compound purified from fenugreek seeds for 15 days in the subdiabetic and moderately diabetic and 30 days in the severely diabetic rabbits corrects the altered serum lipids, tissue lipids, glycogen, enzymes of glycolysis, gluconeogenesis, glycogen metabolism, polyol pathway and antioxidant enzymes. Histopathological abnormalities (fatty infiltration and other cellular changes) seen in the pancreas, liver, heart and kidneys were repaired after treatment with GII. In fact partially damaged pancreas was repaired. Liver and kidney function test results were normal in the GII treated animals indicating that GII treatment is safe and free from any side effects.  相似文献   

A passion for portraits: Elizabeth Cay's pastels     

Thea Burns  Ashok Roy 《文物保护研究》2014,59(5):279-288

Elizabeth Cay (1771–1831), the grandmother of the Scottish physicist James Clerk Maxwell (1831–1879), was a talented amateur pastellist; several of her pastel portraits survive as does her set of pastels. She studied with Archibald Skirving (1749–1819), a Scottish miniature painter who later in life turned to larger-scale portraiture in pastel and served as drawing master to the Edinburgh elite. Cay's pastels are not fabricated sticks but consist of powdered pigment housed in various glass and ceramic containers and were apparently applied by stumps, still in her workbox, or brushes. The Cay color samples were identified by spectrographic analysis, polarized light microscopy, and microchemical tests which, in addition, indicated that a number of pigment mixtures present gave specific hues in keeping with earlier treatise accounts of the preparation of a pastel gamut for practical use. Elizabeth Cay's pastel workbox may be rare surviving evidence of one way, more common that we appreciate today, in which amateurs, and perhaps professionals, practiced pastel painting.  相似文献   

Non‐Anglosaxon Attitudes: British Ethnic Minority Literature in English     

Prabhu S. Guptara 《Cambridge Journal of Education》1984,14(3):3-7

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The diffusion of ideas in the academy: A quantitative illustration from economics     

Shaun P. Hargreaves Heap  Ashok Parikh 《Research Policy》2005,34(10):883-1632

It has long been recognised in policy discussion that the influence of new ideas depends not just on their generation but also on the way in which they diffuse through society. However, while the spread of new ideas in industry has been much studied, there are no similar quantitative studies on diffusion within the academy. This paper addresses that gap by providing quantitative evidence on the adoption of two techniques for empirically testing hypotheses in economics. On the basis of this evidence, and contrary to a common expectation, the spread of ideas seems neither straightforward nor especially rapid in the academy.  相似文献   

A dialogue on education for autonomy — Some critical comments     

Ashok Malla 《Interchange》1989,20(4):48-50

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Power maps and commutativity of groups     

Ashok Singh 《Resonance》2004,9(7):70-73

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Effect of processing parameters on the electromagnetic radiation emission during plastic deformation and crack propagation in copper-zinc alloys     

KUMAR Rajeev  MISRA Ashok 《浙江大学学报(A卷英文版)》2006,7(11):1800-1809

INTRODUCTION The physics of plastic deformation and crack propagation at atomic level is complex but is essential for the development of new materials. This requires an understanding of the atomic level phenomena associated with the plastic deformation. In this con- text, emission of electromagnetic radiation (EMR) during plastic deformation and crack propagation in metals and alloys, and generation of transient mag- netic fields during crack initiation in ferromagnetic materials are rep…  相似文献