Antipsychotics-induced hyperprolactinemia and screening for macroprolactin     

Nedjeljka Ruljancic  Ana Bakliza  Sandra Vuk Pisk  Natko Geres  Katarina Matic  Ena Ivezic  Vladimir Grosic  Igor Filipcic 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(1)

IntroductionHigh prolactin (PRL) concentrations are found in laboratory test results of patients on majority of antipsychotic drugs. Prevalence rates and degrees of severity of hyperprolactinemia (HPRL) based on PRL concentration may depend on the presence of macroprolactin in the serum. The aim of the study was to investigate the difference between PRL concentrations before and after precipitation of macroprolactin and to examine if there were any changes in the categorization of HPRL between samples prior and after precipitation.Materials and methodsTotal of 98 female patients (median age 33; range 19-47 years) diagnosed with a psychotic disorder, proscribed antipsychotic drugs, and with HPRL were included. Total PRL concentration and PRL concentration after macroprolactin precipitation with polyethylene glycol (postPEG-PRL) were determined by the chemiluminometric method on the Beckman Coulter Access2 analyser.ResultsTotal PRL concentrations (median 1471; IQC: 1064-2016 mlU/L) and postPEG-PRL concentrations (median 1453; IQC: 979-1955 mlU/L) were significantly correlated using intraclass correlation coefficient for single measurements (mean estimation 0.96; 95%CI 0.93-0.97) and average measurement (mean estimation 0.98; 95%CI 0.96-0.99), and all investigated female patient had HPRL according to PRL and postPEG-PRL concentration. The median PRL recovery following PEG precipitation was 95; IQC: 90-100%. There was substantial agreement (kappa test = 0.859, 95% CI: 0.764-0.953) between the categories of HPRL severity based on total PRL concentrations and postPEG-PRL concentrations.ConclusionThe study demonstrated that HPRL was present in all subjects using the reference interval for total PRL concentration and postPEG-PRL concentration with no significant impact of macroprolactin presence in the serum on the categorization of patients according to severity of HPRL.  相似文献   

高职辅导员如何建设学习型班级     

揣婀娜 《湖北成人教育学院学报》2015,(2)

在学习型组织理论基础上,分析学习型班级的特点,结合高职学生的特点,提出高职院校进行学习型班级的建设。在高职建设学习型班级,应着重从辅导员自身角色的转变、改变心智模式、自我超越、树立班级共同愿景、形成团队学习机制等方面进行。  相似文献   

齐风鲁韵 源远流长——“山东历史文化展”     

周婀娜  高震  于芹 《中国博物馆》2010,(2):30-37

<正>"山东历史文化展"是配合山东省博物馆新馆建成开放而专门制作的大型地方通史类陈列,承载和担负了向中国乃至世界宣扬博大精深的齐鲁文化的重任,因此丰富的文物藏品和古籍是这次展览的重要保障。  相似文献