Enhancement of myeloperoxidase activity in WBCS in oral cancer patients treated with Granulocyte Macrophage Colony Stimulating Factor (GM-CSF)—A pilot study     

N. Ananth  Ganesh B. Balaji  D. M. Vasudevan MD  FRC  Vivian D’Souza  Ashalatha V. Rao  Dinesh Nambiar 《Indian journal of clinical biochemistry : IJCB》1998,13(2):126-128

In a pilot study with five oral cancer patients undergoing radiotherapy (RT) three were given Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) as a protective agent to reduce the mucosal inflammation during radiotherapy. The myeloperoxidase (MPO) enzyme activity in WBC was quantitated. The three patients showed a significant increase in the MPO activity when compared with two untreated controls indicating the efficacy of GM-CSF as a protective agent. It is suggested that further detailed studies with larger number of patients would be useful.  相似文献