Adverse Events Reported From  COVID-19 Vaccine Trials: A Systematic Review     

Rimple Jeet Kaur  Siddhartha Dutta  Pankaj Bhardwaj  Jaykaran Charan  Sameer Dhingra  Prasenjit Mitra  Kavita Singh  Dharmveer Yadav  Praveen Sharma  Sanjeev Misra 《Indian journal of clinical biochemistry : IJCB》2021,36(4):427

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Computational Thinking and Media & Information Literacy: An Integrated Approach to Teaching Twenty-First Century Skills     

Sarah Gretter  Aman Yadav 《TechTrends》2016,60(5):510-516

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Behavioral Intention to Adopt Digital Library by the Undergraduates     

Krishna Moorthy  Loh Chun T'ing  Kiing Siew Ming  Chiong Chui Ping  Ler Yu Ping  Lim Qiao Joe 《International Information and Library Review》2019,51(2):128-144

The purpose of this research is to investigate the factors that affect undergraduates' behavioral intention to use digital library among the private universities in Malaysia. The target respondents are undergraduates from Malaysian private universities. Questionnaires were distributed among 500 undergraduates through either online or face-to-face method. Reliability test, normality test, Pearson Correlation Coefficient analysis, and Multiple Linear Regression (MLR) were carried out for data analysis. Performance expectancy, social influence, facilitating conditions, hedonic motivation, habit, and information quality had a positive and significant association with behavioral intention to adopt a digital library except for effort expectancy. This research successfully reinforced that the inspiration to ameliorate Unified Theory of Acceptance and Use of Technology 2 (UTAUT 2) by synthesis of Information Systems Success Model (ISSM). This proposed framework with a combination of ISSM and UTAUT 2 has enhanced the fitness of UTAUT 2. Universities that have yet to implement digital library can comprehend undergraduates' needs better by considering all the significant factors to develop a digital library. The universities with the digital library may also notice the important features of the existing digital library that should be maintained and upgraded constantly so that they can fulfil undergraduates' requirements.  相似文献   

Distribution of Methionine Synthase Reductase (MTRR) Gene A66G Polymorphism in Indian Population     

Upendra Yadav  Pradeep Kumar  Vandana Rai 《Indian journal of clinical biochemistry : IJCB》2021,36(1):23

Methionine synthase reductase (MTRR) is an important enzyme of the folate/homocysteine pathway. It is responsible for regulation of methionine enzyme by reductive methylation. A common variant A66G is reported in the FMN-binding domain of the MTRR gene, which leads to substitution of isoleucine by methionine (I22M) in MTRR enzyme with reduced activity. Reduced catalytic activity of enzyme leads to high homocysteine concentration in blood and increases risk for numerous diseases. The frequency of A66G polymorphism varies in different ethnic groups. The present study has been designed to evaluate the frequency of MTRR A66G gene polymorphism in the Eastern UP population by PCR–RFLP method. Along with this we also performed a meta-analysis to evaluate the global prevalence of this polymorphism. Databases were screened to identified the eligible studies. The prevalence of the G allele and GG genotype was determined by the use of prevalence proportion with 95% CI. Open meta-analyst software was used for the meta-analysis. Total 1000 blood samples were analyzed, the frequencies of A and G alleles were 0.35 and 0.65 respectively. Meta-analysis results revealed that the prevalence of G allele and GG genotype were 49.4% (95% CI 40.6–58.1, p ≤ 0.001) and 24.3% (95% CI 17.8–30.9, p ≤ 0.001) respectively. In sub-group meta-analysis, the lowest frequency of G allele was found in South America (32.7%; 95% CI 14.1–51.3, p ≤ 0.001), and highest in Asia (56.4%; 95% CI 39.5–73.3, p ≤ 0.001). The results of the meta-analysis showed that the Asian population has the highest frequency of G allele and highest frequency of the GG genotype was found in the European population.  相似文献   

Antarctic Harsh Environment as Natural Stress Model: Impact on Salivary Immunoglobulins, Transforming Growth Factor-β and Cortisol Level     

K. P. Mishra  A. P. Yadav  Lilly Ganju 《Indian journal of clinical biochemistry : IJCB》2012,27(4):357-362

The Antarctic continent on the planet Earth is full of environmental extremes. It is considered as natural stress model. Therefore, the present study examined the effect of harsh environment on the certain salivary markers of 28th Indian Antarctic expeditioners. Thirty healthy men and women (median age 36 year; range 22–61 year) participated in this study. Parameters measured were salivary IgA (SIgA), IgM (SIgM), TGF-β and cortisol level at three different time points: (I) before leaving India on 26th October 2008 for base line level; (II) after 1 month on-board journey on 31st January 2009 in Southern Ocean and (III) after 1 month staying at Maitri, Antarctica on 3rd March 2009. Our observation indicated that Ship borne journey and Antarctic environment increased the SIgA levels while that of SIgM level was not altered on-board but decreased by staying for 1 month at Antarctica. No significant alteration was found in the TGF-β and cortisol level at any point of time. The present study concluded that ship borne journey and Antarctic environment may induce the SIgA level while SIgM level decreased in environmental extremes of Antarctica.  相似文献   

Retention of EBM competencies     

Dorsch J  Aiyer MK  Gumidyala K  Meyer LE 《Medical reference services quarterly》2006,25(3):45-57

This longitudinal follow-up study surveyed the attitudes toward, and skills in, evidence-based medicine (EBM) of medical school graduates who had participated in a formal EBM curriculum during their third-year Internal Medicine (IM) clerkship. The objective was to measure whether competencies were retained over time and to identify the long- term impact on the graduates' attitudes toward, and proficiency in, EBM after graduation. Questionnaire results showed that a group of medical school graduates retained EBM skills and a positive attitude about the importance of applying EBM principles in patient care one to three years after completing an EBM course.  相似文献   

Cord Blood Insulin Levels: It’s Correlation with Gender,Birth Weight and Placental Weight in Term Newborns     

Afzal Ahmad  Rukmini Mysore Srikantiah  Charu Yadav  Ashish Agarwal  Poornima Ajay Manjrekar  Anupama Hegde 《Indian journal of clinical biochemistry : IJCB》2016,31(4):458-462

The cause of more insulin resistance in female than males are still unknown. To know the cause from early life, normal values of relevant parameters are required. So, aim of this study was to determine the reference levels of glucose and insulin in cord blood of term newborns and to examine their effects on gender, placental and birth weight of term newborns. In cross sectional study 60 consecutive term newborns were included from constituent hospitals. Placental and birth weights were measured and cord blood was collected for estimation of serum insulin and plasma glucose. Plasma glucose estimation was done by auto analyzer (GOD–POD method) and serum insulin analysis was done using Insulin ELISA Kit. After analysis, mean ± 2SD used for estimating cord blood insulin and glucose levels, which were 10.1 ± 7.8 μIU/mL and 67.8 ± 33.8 mg/dL respectively. Correlation of insulin with both birth weight and placental weight were r = 0.359 and 0.41 respectively; p < 0.001. Interestingly we found higher insulin levels in females as compared to male newborns in spite of having lower birth weight in them. In conclusion this study reported the levels of insulin and glucose in cord blood of term newborns. Incidentally, this is the first study as per our knowledge to report significant correlation between cord blood insulin, glucose with birth weight, placental weight and gender in south India. Female newborns had higher insulin levels than males, despite lesser birth weight can be attributed to intrinsic insulin resistance in them.  相似文献   

Cross-Sectoral Differences in Intellectual Property Enforcement in Developing Countries: The Role of State-Industry Linkages     

Krishna P. Jayakar 《The Information Society》2003,19(2):155-169

Leading developing countries have recently introduced some reforms in their national intellectual property regimes to harmonize them with international treaties and agreements. However, major differences remain in how these laws are applied to different information industries, and how they are enforced on the ground. While intellectual property law applies to a host of information products ranging from music to computer programs, governments have selectively enforced the law in some information industries, while neglecting to extend the same protection to others. Based on the comparative institutionalist approach, this article identifies two variables--state-industry linkages and level of innovative activity--that may explain the selective enforcement of intellectual property law. Intellectual property rights were expected to be better protected in information industries with strong state-industry linkages and higher levels of domestic innovation. This expectation was tested through a comparative study of four intellectual property industries from the Asian region. The results confirmed the expectation, but also demonstrated that strong state-industry linkages may independently correlate with high levels of intellectual property protection, even in industries where the current levels of innovative activity are low.  相似文献   

Effect of thiazide drug compound on the testicular protein and cholesterol contents of albino rat     

Hemlata Yadav  P. K. Singh 《Indian journal of clinical biochemistry : IJCB》2003,18(2):206-208

In this study the effect of thiazide diuretic compound on the protein and cholesterol contents in the testes of albino rats as the experimental model. The drug thiazide was administered orally daily for 10,20 and 30 days at the dose of 100mg/kg body weight. Total protein decrease in the testes of rats were evidenced may be due to the side effects of thiazide drug compound which is linked with the hyponatremia and protein metabolism. An elevated level of cholesterol contents observed in thiazide treated rats also revealed that the side effect of drug compound thiazide and also may be due to the stimulation of catecholamine which is stimulated therefore, the biochemical estimation such as protein and cholesterol in the testes after the thiazide treatment determined the effectiveness of diuretic drug compound would provide clinical evidences of their side effects.  相似文献   

Profiles of educators     

Krishna Kumar  Serge Wagner  Ananda W. P. Guruge  Miguel Soler Roca  Francisco Gomes de Matos 《Prospects》1989,19(4):591-619

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