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Iron deficiency evolves, slowly through several stages. Early iron deficiency caused a depletion in iron stores as shown by
a reduction in the levels of hepatic non heme iron (44%) in the 7 days old pups born to iron deficient mothers. The hemoglobin
levels and PCV (packed cell volume) were significantly reduced only after the age of three weeks. The activities of GABA (γ-amino
butyric acid) shunt enzymes viz. GDH, GAD and GABA-T (glutamate dehydrogenase, glutamate decarboxylase and GABA-transaminase,
respectively) and GABA content were found to decrease during gestation and/or lactation iron deficiency at 1 week (wk), 2wk,
3wk and 4wk of age in the developing rat brains. However GABA binding showed a significant increase at different age groups.
The iron deficiency during lactational exposure showed significant alteration in most of the parameters only at the age of
3 weeks onwards. On rehabilitation with iron supplemented diet for 2 weeks, these altered parameters could not attain corresponding
control values. A prolonged iron deficiency causing alterations in GABA may lead to neurological and behavioral alterations. 相似文献
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Jyoti P. Gurung Moein Navvab Kashani Sanaz Agarwal Gonzalo Peralta Murat Gel Matthew A. B. Baker 《Biomicrofluidics》2021,15(3)
Many motile bacteria are propelled by the rotation of flagellar filaments. This rotation is driven by a membrane protein known as the stator-complex, which drives the rotor of the bacterial flagellar motor. Torque generation is powered in most cases by proton transit through membrane protein complexes known as stators, with the next most common ionic power source being sodium. Sodium-powered stators can be studied through the use of synthetic chimeric stators that combine parts of sodium- and proton-powered stator proteins. The most well studied example is the use of the sodium-powered PomA-PotB chimeric stator unit in the naturally proton-powered Escherichia coli. Here we designed a fluidics system at low cost for rapid prototyping to separate motile and non-motile populations of bacteria while varying the ionic composition of the media and thus the sodium-motive force available to drive this chimeric flagellar motor. We measured separation efficiencies at varying ionic concentrations and confirmed using fluorescence that our device delivered eightfold enrichment of the motile proportion of a mixed population. Furthermore, our results showed that we could select bacteria from reservoirs where sodium was not initially present. Overall, this technique can be used to implement the selection of highly motile fractions from mixed liquid cultures, with applications in directed evolution to investigate the adaptation of motility in bacterial ecosystems. 相似文献
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Iron deficiency evolves slowly through several stages. Early iron deficiency caused a depletion in iron stores as shown by
a reduction in the levels of hepatic non-heme iron in the new born of iron deficient mothers. Of particular importance is
the effect on central nervous system, which leads to the defects in the cognition and learning processes in humans. Evidence
is strong that in many under developed countries iron deficiency is the main cause of anaemia and supplementation under trial
conditions may prevent some defects of iron deficiency but not all. 相似文献
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Neelima Verma Jyoti chakraverty Pankaj Baweja Alka Girotra Leena Chatterjee Manish Chugh 《Indian journal of clinical biochemistry : IJCB》2017,32(1):117-120
Hyperferritinemia (>10,000 ng/ml) is an important hallmark used as an indicator of infection triggered macrophage activation syndrome leading to hemophagocytic lympho histiocytosis (HLH). Measurement of serum ferritin can be used in diagnosis as well as disease monitoring indicator and prognosis related to HLH, cAPS, sepsis, neoplasm and inflammatory conditions. It is a major contributor to manage critically ill patients as predicting and monitoring indicator. It can be used as acute phase response in conditions of MAS, AOSD, cAPS etc. A case study in our hospital showed extremely high ferritin values along with low hemoglobin, elevated LDH and triglycerides with positive MRSA in sputum culture and macrophage proliferation and hemophagocytosis in the bone marrow examination. Patient showed definite inverse relation with steroid therapy and serum ferritin levels. 相似文献
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Anuradha Bharosay Vivek Vikram Bharosay Kiran Saxena Meena Varma 《Indian journal of clinical biochemistry : IJCB》2018,33(2):178-183
This study was undertaken to evaluate the role of serum neuron specific enolase (NSE) in prediction of disability and neurological worsening in hypertensive ischemic cerebrovascular stroke. 80 hypertensive ischemic stroke patients diagnosed by a neurologist as per WHO definition along with radiological findings suggestive of cerebrovascular stroke and differentiating from hemorrhagic stroke and 60 controls having essential hypertension coming to hospital because of regular checkup or headache but with no neurological disease were included in the study. Neurological disability was assessed by NIHSS at the time of admission (within 72 h from the onset of stroke) and on 7th day after admission and cases were categorized into mild, moderate and severe disability. Venous blood samples were drawn within 72 h from the onset of symptoms. The samples were processed as per the laboratory protocol. The serum NSE samples were analyzed using an enzyme immunoassay based on the sandwich technique. We observed raised serum NSE in hypertensive ischemic stroke (17.4 ± 5.4 ng/ml) with significant association between different hypertensive groups than in hypertensive controls (9.1 ± 0.75 ng/ml). Greater degree of disability was observed in hypertensive stroke patients with raised serum NSE and hypertensive patients with mean serum NSE level of 22.9 ± 3.6 ng/ml and dyslipidemia had greater probability of neurological worsening as compared to those with mean serum NSE level of 12.7 ± 1.2 ng/ml. Serum NSE levels can serve as a peripheral indicator of neuronal damage and assist in the prediction of disability and clinical outcome in hypertensive cerebrovascular ischemic stroke patients. 相似文献
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R. P. Saxena 《Higher Education》1990,20(1):91-111
India with a current student population of around 4 million in its universities and colleges is the third largest system in the world after USA and USSR. The unprecedented expansion of higher education in India, which took place in the last four decades, has, however, been extremely uneven and resulted in the neglect of quality, research and managements aspects. The universities and colleges function much below their optimal levels and fail even to fulfil their minimum and basic tasks such as making admissions, completing teaching, conducting examinations, declaring results and awarding degrees on time. The very credibility of the university system stands eroded.Increasing government control, extra-constitutional pressures in their governance, appointment and dismissal of Vice-Chancellors on political considerations and drift of the academic community from serious academic pursuits have undermined the autonomy of the universities. The paper attempts to analyse from macro-micro angles the causes for the decay of the university system.The National Policy on Education-1986 aims at radical reorganisation of higher education to bring about dynamism in the system through multi-pronged strategies and programmes and structural reforms. Policy interventions have, however, failed to create much impact. The paper brings forth some of the important issues vital to the governance of the universities and highlights the need for a collective endeavour of teachers, students, educational administrators and government and rigorous system of performance audit to bring dynamism into the system. 相似文献
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In search of self-efficacy: development of a new instrument for first year Computer Science students
Jyoti Bhardwaj 《Computer Science Education》2017,27(2):79-99
This study explores the changes in Computer Science (CS) students’ self-efficacy between entering study and the end of first year of university. It aims to give course leaders insights into the everyday challenges that affect students’ academic achievement and persistence into second year. The paper begins by proposing that the way CS is taught, the gender imbalance on CS courses, and the experience of the key transitional year into university might influence CS students’ non-continuation. It adopts an academic buoyancy conceptualisation of resilience. Acknowledging the scarcity of instruments covering CS students’ transition to university, the development of a new 20-item questionnaire is described, based on CS students’ own contributions of the challenges they faced during first year. The instrument is administered twice in one session to the same cohort. Analysis of paired responses indicates a loss of confidence to overcome challenges in most aspects, particularly staying motivated to study. 相似文献