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1.
R. Shukia S. B. Sharma D. Puri K. M. Prabhu P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》2000,15(1):169-177
Many plants have been used for the treatment of diabetes mellitus in Indian system of medicine and in other ancient systems of the world. Out of these only a few have been evaluated as per modern system of medicine. From many such plants only extracts have been prepared and their usefulness evaluated in experimental diabetes in animals. In some plants likeAllium cepa, Allium sativum, Ficus bengalensis, Gymnema sylvestre, Pterocarpus marsupium etc. active hypoglycemic principles have been isolated and their mechanism of action studied. Most of them seem to act directly on pancreas (pancreatic effect) and stimulate insulin level in blood. Some have extra pancreatic effect also by acting directly on tissues like liver, muscle etc. and alter favourably the activities of the regulatory enzymes of glycolysis, gluconeogenesis and other pathways. Since the plant products have less side effects, they have the potential as good hypoglycemic drugs. They may also provide clues for the development of new and better oral drugs for diabetes. 相似文献
2.
D. Puri K. M. Prabhu G. Dev S. Agarwal P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》2011,26(4):335-346
To study the mechanism of action of water soluble compound GII purified from fenugreek (Trigonella foenum graecum) seeds which was shown earlier to have antidiabetic effect in the subdiabetic, moderately and severely diabetic rabbits.
In rabbits (1–1.5 kg bw) diabetes was induced by intravenous injection of 80 mg/kg bw of alloxan. They were fed with GII at
a dose of 50 mg/kg bw daily once in the morning for 15 days in the subdiabetic and moderately diabetic and 30 days in the
severely diabetic rabbits. Serum total cholesterol (TC), triglycerides (TG), LDL + VLDL cholesterol [(LDL + VLDL)C], HDL cholesterol
[(HDL)C], total tissue lipids, glycogen and enzymes of carbohydrate metabolism (glycolysis, gluconeogenesis, polyol pathway)
hexokinase, glucokinase, pyruvate kinase, malic enzyme, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, aldose reductase
and sorbitol dehydrogenase and antioxidant enzymes glutathione peroxidase, glutathione reductase and superoxide dismutase
were estimated. Liver and kidney function parameters were also estimated. Treatment with GII for 15 days in the subdiabetic
and moderately diabetic rabbits and for 30 days in the severely diabetic rabbits (i) decreased the elevated lipids TC, TG,
(LDL + VLDL)C and increased the decreased (HDL)C, (ii) decreased the elevated liver and heart total lipids, TC and TG, (iii)
increased the decreased liver and muscle glycogen, (iv) increased the decreased hexokinase, glucokinase, pyruvate kinase,
malic enzyme, glucose-6-phosphate dehydrogenase, superoxide dismutase, glutathione peroxidase, (v) decreased the increased
glucose-6-phosphatase, sorbitol dehydrogenase, aldose reductase. Results thus show that treatment with GII compound purified
from fenugreek seeds for 15 days in the subdiabetic and moderately diabetic and 30 days in the severely diabetic rabbits corrects
the altered serum lipids, tissue lipids, glycogen, enzymes of glycolysis, gluconeogenesis, glycogen metabolism, polyol pathway
and antioxidant enzymes. Histopathological abnormalities (fatty infiltration and other cellular changes) seen in the pancreas,
liver, heart and kidneys were repaired after treatment with GII. In fact partially damaged pancreas was repaired. Liver and
kidney function test results were normal in the GII treated animals indicating that GII treatment is safe and free from any
side effects. 相似文献
3.
4.
Ron Tamborini Robert J. Lewis Sujay Prabhu Matthew Grizzard Lu Wang 《Communication Research Reports》2016,33(3):177-187
Previous research suggests that media featuring exemplars of specific altruistic motivations can make those motivations more accessible in viewers’ minds. The present study extends this research to also examine egoistic motivations. We (a) developed a coding scheme to examine how frequently exemplars of altruistic and egoistic motivations appear in media content, (b) developed an intuitive motivation-affect misattribution procedure to measure the accessibility of altruistic and egoistic motivations, and (c) examined whether exposure to media content portraying specific motivations makes those motivations more accessible in audiences. The findings are discussed in terms of the model of intuitive morality and exemplars. 相似文献
5.
Vijetha Shenoy Veena Mehendale Krishnananda Prabhu Ranjan Shetty Pragna Rao 《Indian journal of clinical biochemistry : IJCB》2014,29(3):339-344
Coronary artery disease (CAD) has become the most common cause of mortality in the entire world. Homocysteine is implicated as an early atherosclerotic promoter. We studied the relationship between levels of serum homocysteine with severity of coronary artery disease. Total of 70 subjects who scheduled for coronary angiogram consented to participate in this study. In all the patients Gensini scoring system was used to assess the severity of CAD. Venous samples were taken from the patients in fasting state before angiography. Homocysteine levels in patients were measured by enzyme linked immunosorbant method and were compared with respective Genseni scores of participants. Fasting serum homocysteine levels in CAD patients were significantly higher than patients without coronary artery disease (p < 0.001). Also Homocyseine levels correlated significantly with increasing severity of CAD (p < 0.001). Serum homocysteine levels correlated well with the severity of CAD. 相似文献
6.
Can serum Glutathione-S-transferase levels in carcinoma cervix be a predictor of radiation response?
Krishnananda Prabhu P. Gopalakrishna Bhat D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2005,20(1):95-97
We conducted a pilot study wherein serum Glutathione-S-transferase levels were measured before and after radiotherapy in carcinoma
cervix patients and correlated with response to treatment during a two-year follow-up period. Out of 17 patients who received
radiotherapy, 9 showed a significant decrease (p<0.005) while 8 showed significant increase (p<0.004) in post radiotherapy
glutathione-S-transferase values as compared to pre treatment values respectively. These patients were followed up for two
years and we observed that 71% who had significant increase in post radiotherapy values had relapse of cancer within 2 years
where as 66% of those who had significant decrease in post radiotherapy values had no evidence of relapse. This shows that
alterations in serum Glutathione-S-transferase levels may help us to predict radiation response 相似文献
7.
C. R. Wilma Delphine Silvia D. M. Vasudevan K. Sudhakar Prabhu 《Indian journal of clinical biochemistry : IJCB》2002,17(2):104-107
Serum β2-microglubin (β2-m) levels were measured in oral carcinoma patients and compared with normal healthy controls. It was observed that there
was a significant rise in serum β2-microglobulin in oral carcinoma patients. Progressively higher values were obtained as the cancer advanced clinically. Therefore
the estimation of serum β2-microglobulin may be useful as one of a battery of tests in the assessment of oral carcinoma patients. 相似文献
8.
Of the world's largest child labor force in India, Bombay has over 30,000 working children, most of them migrants. In a prospective study of 73 working children from a part of Dharavi, the biggest slum in Asia, 68% were working as hotel boys; 22% had started working before their 10th birthday, a large number doing so to increase the family income, but earning less than Rs. 100 ($11) per month. Forty percent worked more than 12 hours a day and only 16% continued schooling. Two-thirds depended entirely on their employers for food which was adequate and no child in the study was malnourished. Overall incidence of anemia and vitamin deficiency was 10% each. Only 7% had ailments related to their occupation. Because this was a cross-sectional study no conclusions can be drawn regarding long term and residual effects. Preventing children from working is likely to make worse their own as well as their families' problems unless substitute sources of income or welfare are available. Legal protection and other services near their working places are essential for those who have to work. 相似文献
9.
Rimi Shukla Kiran Anand K. M. Prabhu P. Suryanarayana Murthy 《Indian journal of clinical biochemistry : IJCB》1995,10(1):14-18
The hypocholesterolemic effect of the water extract of the bark ofFicus bengalensis was investigated in 3 groups of rabbits, 5 in each group. Group 1 rabbits served as healthy controls and were fed with groundnut oil 1 ml/kg body wt. (bw) for five weeks. Groups 2 and 3 were made hypercholesterolemic by feeding orally cholesterol suspended in groundnut oil (1 ml/kg bw) at a dose of 100 mg/kg bw/day. Group 2 animals (untreated) continued to get the same amount of cholesterol for another four weeks. Group 3 animals received water extract of the bark (50 mg/kg bw/day) in addition to cholesterol as above. At the end of the 5th week, water extract not only prevented the elevation of serum cholesterol in the treated animals (Group 3) but also brought down its level to 160±14 mg% as compared to untreated animals (Group 2) 290±42 mg%. There was improvement in other parameters of lipid profile namely HDL & LDL+VLDL cholesterol and triacylglycerol. 相似文献
10.
Mungli Prakash Jeevan K. Shetty Sambit Dash Bijay K. Barik Abhirup Sarkar Sharanabasappa M. Awanti Ravindra Prabhu 《Indian journal of clinical biochemistry : IJCB》2008,23(4):404-406
Total thiol status of plasma, especially thiol groups over protein contributes maximum to the plasma antioxidant status of
the body. Serum protein thiols were found to be decreased in various disease conditions including chronic renal failure patients.
Only few studies determined the levels of urinary protein thiols in disease conditions. The current study was designed to
know the levels of urinary protein thiols in patients with different grades of proteinuria. The study was conducted on urine
of 40 healthy controls and 61 cases with proteinuria. Based on proteinuria cases were further divided into two groups; group
I - microproteinuria (150–300 mg protein/d), 32 cases, group II - frank proteinuria (>300 mg protein/d), 29 cases. Urinary
thiol levels were determined by spectrophotometric method using dithionitrobenzoic acid. A significant decrease (p<0.01) in
urinary thiol in group I and group II cases was observed in present study and this decrease was associated with proteinuria. 相似文献