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Faezeh Farivar Mahdi Aliyari Shoorehdeli Mohammad Teshnehlab 《Journal of The Franklin Institute》2012,349(7):2243-2267
Despite active research and significant progress in the last three decades on control of human eye movements, it remains challenging issue due to its applications in prosthetic eyes and robotics. Till now, no considerable investigation of this subject is presented in the interdisciplinary sciences. The goal of this paper is to present a distinguished survey of existing literature on the intelligent control of the human eye movements system applied in a huggable pet-type robot as a biomechatronic system.In this study, the basic knowledge of human eye movements control is explained to show how the neural networks in the brainstem control the human eye movements. The geometry and model of human eye movements system are investigated and this system is considered as a nonlinear control system. The specified model may only be an academic exercise. It can have scientific importance in understanding of the human movement system in general. Also, it can be useful for robotics.Intelligent methods such as artificial neural networks and fuzzy neural networks are proposed to control the human eye movements and numerical simulations are presented. It is discussed that the intelligent controls applied to control of human eye movements system are emulated from the neural controls in biological system. 相似文献
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Tiwari AK Mahdi AA Zahra F Chandyan S Srivastava VK Negi MP 《Indian journal of clinical biochemistry : IJCB》2010,25(4):411-418
The present study was conducted to investigate the oxidant–antioxidant status in iron deficient pregnant anemic women. One
hundred thirty pregnant women with iron deficiency anemia (IDA) were divided into three groups, namely mild (50), moderate
(50) and severe (30) anemic along with pregnant healthy women as controls (50). The complete blood count, plasma lipid peroxidation
products, enzymatic and non-enzymatic antioxidants were measured according to respective protocols. The levels of complete
blood count, iron, ferritin along with antioxidant enzymes namely catalase, superoxide dismutase, glutathione peroxidase,
glutathione reductase and reduced glutathione were significantly reduced in all IDA groups. However, the level of oxidized
glutathione, lipid peroxides, protein carbonyls, conjugated dienes were found significantly increased in all anemic patients.
Antioxidant vitamins, namely C, E and A were also found significantly decreased in IDA patients. On the basis of our results,
it may be concluded that IDA tends to increase the pro-oxidant components, which may result in various complications including
peroxidation of vital body molecules resulting in increased risk for pregnant women as well as fetus. 相似文献
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Singh PP Chandra A Mahdi F Roy A Sharma P 《Indian journal of clinical biochemistry : IJCB》2010,25(3):225-243
The antioxidants are essential molecules in human system but are not miracle molecules. They are neither performance enhancers
nor can prevent or cure diseases when taken in excess. Their supplemental value is debateable. In fact, many high quality
clinical trials on antioxidant supplement have shown no effect or adverse outcomes ranging from morbidity to all cause mortality.
Several Chochrane Meta-analysis and Markov Model techniques, which are presently best available statistical models to derive
conclusive answers for comparing large number of trials, support these claims. Nevertheless none of these statistical techniques
are flawless. Hence, more efforts are needed to develop perfect statistical model to analyze the pooled data and further double
blind, placebo controlled interventional clinical trials, which are gold standard, should be implicitly conducted to get explicit
answers. Superoxide dismutase (SOD), glutathione peroxidase and catalase are termed as primary antioxidants as these scavenge
superoxide anion and hydrogen peroxide. All these three enzymes are inducible enzymes, thereby inherently meaning that body
increases or decreases their activity as per requirement. Hence there is no need to attempt to manipulate their activity nor
have such efforts been clinically useful. SOD administration has been tried in some conditions especially in cancer and myocardial
infarction but has largely failed, probably because SOD is a large molecule and can not cross cell membrane. The dietary antioxidants,
including nutrient antioxidants are chain breaking antioxidants and in tandem with enzyme antioxidants temper the reactive
oxygen species (ROS) and reactive nitrogen species (RNS) within physiological limits. Since body is able to regulate its own
requirements of enzyme antioxidants, the diet must provide adequate quantity of non-enzymic antioxidants to meet the normal
requirements and provide protection in exigent condition. So far, there is no evidence that human tissues ever experience
the torrent of reactive species and that in chronic conditions with mildly enhanced generation of reactive species, the body
can meet them squarely if antioxidants defense system in tissues is biochemically optimized. We are not yet certain about
optimal levels of antioxidants in tissues. Two ways have been used to assess them: first by dietary intake and second by measuring
plasma levels. Lately determination of plasma/serum level of antioxidants is considered better index for diagnostic and prognostic
purposes. The recommended levels for vitamin A, E and C and beta carotene are 2.2–2.8 μmol/l; 27.5–30 μmol/l; 40–50 μmol/l
and 0.4–0.5 μmol/l, respectively. The requirement and recommended blood levels of other dietary antioxidants are not established.
The resolved issues are (1) essential to scavenge excess of radical species (2) participants in redox homeostasis (3) selective
antioxidants activity against radical species (4) there is no universal antioxidant and 5) therapeutic value in case of deficiency.
The overarching issues are (1) therapeutic value as adjuvant therapy in management of diseases (2) supplemental value in developing
population (3) selective interactivity of antioxidant in different tissues and on different substrates (4) quantitative contribution
in redox balance (5) mechanisms of adverse action on excess supplementation (6) advantages and disadvantages of prooxidant
behavior of antioxidants (7) behavior in cohorts with polymorphic differences (8) interaction and intervention in radiotherapy,
diabetes and diabetic complications and cardiovascular diseases (9) preventive behavior in neurological disorders (10) benefits
of non-nutrient dietary antioxidants (11) markers to assess optimized antioxidants status (12) assessment of benefits of supplementation
in alcoholics and heavy smokers. The unresolved and intriguing issues are (1) many compounds such as vitamin A and many others
possessing both antioxidant and non-antioxidant properties contribute to both the activities in vivo or exclusively only to
non-antioxidant activity and (2) since human tissues do not experience the surge of FR, whether there is any need to develop
stronger synthetic antioxidants. Theoretically such antioxidants may do more harm than good. 相似文献
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Mahdi Dehghan Maryam Biabani Ahmad Ali Abin 《Information processing & management》2019,56(3):1067-1079
Cost optimization continues to be a critical concern for many human resources departments. The key is to balance between costs and business value. In particular, computer science organizations prefer to hire people who are expert in only one skill area and have a slight superficial knowledge in other areas that gives them the ability to collaborate across different aspects of project. Community Question Answering networks provide good platforms for people and organizations to share knowledge and find experts. An important issue in expert finding is that an expert has to constantly update his knowledge after being saturated in his field of expertise to still be identified as expert. A person who fails to preserve his expertise is likely to lose his expertise. This work justifies this question that does take the concept of time into account improve the quality of expertise retrieval. We propose a new method for T-shaped expert finding that is based on temporal expert profiling. The proposed method takes the temporal property of expertise into account to mine the shape of expertise for each candidate expert based on his profile. To this end, for each candidate expert, we take snapshots of his expertise trees at regular time intervals and learn the relation between temporal changes in different expertise trees and candidates’ profile. Finally, we use a filtering technique that is applied on top of the profiling method, to find shape of expertise for candidate experts. Experimental results on a large test collection show the superiority of the proposed method in terms of quality of results in comparison with state-of-the-art. 相似文献
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The need for cell and particle sorting in human health care and biotechnology applications is undeniable. Inertial microfluidics has proven to be an effective cell and particle sorting technology in many of these applications. Still, only a limited understanding of the underlying physics of particle migration is currently available due to the complex inertial and impact forces arising from particle–particle and particle–wall interactions. Thus, even though it would likely enable significant advances in the field, very few studies have tried to simulate particle-laden flows in inertial microfluidic devices. To address this, this study proposes new codes (solved in OpenFOAM software) that capture all the salient inertial forces, including the four-way coupling between the conveying fluid and the suspended particles traveling a spiral microchannel. Additionally, these simulations are relatively (computationally) inexpensive since the arbitrary Lagrangian–Eulerian formulation allows the fluid elements to be much larger than the particles. In this study, simulations were conducted for two different spiral microchannel cross sections (e.g., rectangular and trapezoidal) for comparison against previously published experimental results. The results indicate good agreement with experiments in terms of (monodisperse) particle focusing positions, and the codes can readily be extended to simulate two different particle types. This new numerical approach is significant because it opens the door to rapid geometric and flow rate optimization in order to improve the efficiency and purity of cell and particle sorting in biotechnology applications. 相似文献
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Alireza Karimi Reza Razaghi Mahdi Navidbakhsh Toshihiro Sera Susumu Kudo 《Sports Engineering》2016,19(2):105-115
Although it might be believed that the eye only comprised a very small area of the face, its injury due to the ball impacts in different sports seems to be severe enough to entice many researchers to determine the level of injury and then attempt to minimize it. Sports-related eye injuries, especially tennis, pose a substantial and preventable problem to the eye due to the high speed of the tennis ball (69 m/s). This is why many ophthalmologists provide a wide range of information for their patients regarding the risks of eye injuries in tennis to prevent the injury to well over 100,000 eyes each year. However, so far although there are some general information regarding the injury to the human eye components due to the tennis ball impact, the details of the stresses and deformations have not been well determined. Therefore, the goal of this study was to determine the stresses and deformations of the eye components, including cornea, aqueous body, iris, ciliary body, lens, vitreous body, retina, sclera, optic nerve, extra and intraconal fats, and muscles, attributable to the tennis ball impact via a Lagrangian–Eulerian computational coupling model. Magnetic resonance imaging was employed to establish a finite element model of the human eye according to a normal human eye. The numerical results revealed the highest amount of stress in the iris (19.2 MPa), whereas the lowest one was observed in the vitreous body (1.77 Pa). The cornea also experienced the stress of 8.27 MPa which might be high enough to invoke rupture in this delicate material. In addition, the results exhibited a decreasing and increasing of the radius of curvature for the cornea and lens, respectively. Finally, the collision of the tennis ball to the eye triggered the resultant displacement of 0.045 µm in the optic nerve which may imply a non-significant injury to that. The findings of this study may have implications not only for understating the values of stresses and deformations in the human eye components but also for helping the ophthalmologists to have a more precise diagnosis about the injury position in the eye due to the tennis ball impact. 相似文献
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Ishrat Husain Ramesh Chander Jitendra Kumar Saxena Abbas Ali Mahdi Farzana Mahdi 《Indian journal of clinical biochemistry : IJCB》2015,30(1):72-77
The antidyslipidemic activity of Ocimum sanctum leaf extract was studied in streptozotocin induced diabetic rats. In this model, there was significant increase in plasma markers of diabetic-dyslipidemia following diminution of lipid metabolizing enzymes. Oral administration of leaf extract (500 mg/kg b.w.p.o.) for 15 days resulted in significant decrease in diabetogenic and dyslipidemia parameters; namely blood glucose, glycosylated hemoglobin, lipid peroxide, free fatty acids, small dense low density lipoprotein, lipid and protein components of plasma lipoproteins, adipose and liver. The regulation of lipids was accompanied by stimulation of postheparin lipolytic activity, reactivation of lecithin cholesterol acyl transferase and hepatic lipoprotein lipase enzymes. The results of the present study demonstrated antidyslipidemic and antioxidant activities in leaf extract of O. sanctum which could be used in prevention of diabetic-dyslipidemia and related complications. 相似文献