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The concepts of photoperiodic induction, hormonal regulation and florigens used to form the basis of our knowledge of flowering. Consequent upon the advancement of technology, our present day understanding suggests that a number of events like switching on of a cascade of genes, and the subsequent activation of MADS box genes, result in the activation of the the genes responsible for flowering in angiosperms.  相似文献   
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The levels of fasting glucose, fasting insulin, insulin resistance (IR) and the prevalence of metabolic syndrome (MS) in a sample population of bipolar disorder (BPD) patients who were newly diagnosed and psychotropically naïve were assessed and compared with an age, sex and racially matched control population. 55 BPD-I patients (15–65 years) who were non-diabetic, nonpregnant, and drug naïve for a period of at least 6 months were included in the study. Diagnosis was made using the structured clinical interview for DSM-IV axis I disorders (SCID IV). IR was assessed using homeostasis model of insulin resistance (HOMA-IR); MS was defined according to National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III). Data were compared with 25 healthy controls. BPD patients had significantly higher mean levels of fasting plasma insulin (13.2 ± 9.2 vs. 4.68 ± 3.1 μIU/ml, p < 0.05), postprandial plasma insulin (27.2 ± 14.5 vs. 18.1 ± 9.3 μIU/ml, p < 0.05) and a higher value of HOMA-IR (3.16 ± 2.2 vs. 1.19 ± 0.8, p < 0.05) when compared to the controls. A significantly higher proportion of patients of BPD compared to controls were manifesting levels of fasting plasma glucose, serum triglyceride and blood pressure higher than the cut off while waist circumference and serum HDL cholesterol failed to show any significant difference in the proportion. There was a significantly higher proportion of prevalence of IR between BPD cases and controls (26/55 vs. 2/25, z value 9.97, p < 0.05) while there was no significant difference in proportion of prevalence of MS between these two groups. Within BPD patients, logistic regression analysis showed that age, sex or current mood status (depressed/manic) were not significantly predictive of presence or absence of MS or increased IR.  相似文献   
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Ashitava Ghosal 《Resonance》2010,15(8):699-710
Ferdinand Freudenstein is widely acknowledged to be the father of modern kinematics of mechanisms and machines. His PhD thesis in 1954 and subsequent research papers by him and his students have influenced academic and industrial research, teaching and practice related to the analysis and design of mechanisms and machines throughout the world. In this article, we revisit Freudenstein’s thesis and the equation named after him. The Freudenstein equation results from an analytical approach towards analysis and design of four-link mechanisms which, along with its variants, are present in a large number of machines used in daily life.  相似文献   
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