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This paper aims to analyse the practice of knowledge integration (KI) in Collaborative New Product Development (Co-NPD) projects involving multiple partners in an aerospace network. On the basis of a pragmatic approach, a multiple-case study is developed focusing on two Italian aerospace companies involved in a research project aimed to define methodologies and technologies for knowledge collaboration in NPD. Data are gathered with a triangulation technique merging official documents and open-ended and closed-ended interviews administered in the companies’ sites and involving managers, engineers and employees. The paper proposes a systematic treatment of the KI practice describing the types of knowledge, strategies, barriers and intellectual property policies for KI at inter-organizational level. The findings provide insights to address NPD models for aerospace networks where the complexity and value of codified knowledge coming from external sources requires adequate treatments and security standards. 相似文献
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Angelo?Corallo Mariangela?Lazoi Giustina?SecundoEmail author Paolo?DePaolis 《知识管理研究与实践》2016,14(4):478-488
This paper presents a conceptual model to explore the knowledge integration (KI) practices of internal and external company actors involved in the New Product Development (NPD) process of the aerospace industry. The model is based on the linkage of elasticity principles, particularly Hooke’s Law, to Knowledge Management theory. KI practices are considered as a force pushing the NPD process and are metaphorically described as the spring addressed by Hooke’s law. The integration of the knowledge of internal and external company actors impacts NPD, reducing the dimensions of the whole process, in terms of phases, through the application of the concurrent engineering approach. The whole NPD process is improved in terms of the reduction of uncertainty and complexity, and with an ‘integrated energy’ that sustains the pressure of the fast-changing competitive environment. The model is explored to provide an interpretation of the conceptualisation phase of a new aerospace product development process. Qualitative data were collected and analysed. Insights regarding the applications of the model and the theoretical implications are also provided for applications in other industries. 相似文献
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Mariangela Lundgren-Resenterra Peter E. Kahn 《British Educational Research Journal》2019,45(2):407-424
Research on the impact of professional doctorates on students and their organisations has reported contested outcomes. We undertook a study to develop a causal explanation of how organisational change may, or may not, result from participation in a Doctor of Education programme (EdD). Drawing on critical realist perspectives, the research found that all the doctoral students shared professional concerns with their work colleagues. In some cases, however, this sharing fostered social relations that supported both collective meta-reflexivity and a performative collective reflexivity, and that resulted in organisational change. Variation in the students’ impact on their organisations was further connected to their organisational roles, and to the extent to which their agency aligned with organisational agendas or other external regulatory and normative systems. Strictly limited, or no, organisational change was, however, evident where collective reflexivity was seen to be restricted or to involve contestation. The article concludes that there is significant value to gain by conceiving learning on a professional doctorate not simply in terms of personal growth, but also in terms of mastering a discourse that crosses both research and professional practice and developing the capacity to draw others into that discourse in an organisationally relevant and yet critical fashion. 相似文献
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Mariangela Mortato Laura Blasi Giovanna Barbarella Simona Argentiere Giuseppe Gigli 《Biomicrofluidics》2012,6(4)
Herein proposed is a simple system to realize hands-free labeling and simultaneous detection of two human cell lines within a microfluidic device. This system was realized by novel covalent immobilization of pH-responsive poly(methacrylic acid) microgels onto the inner glass surface of an assembled polydimethylsiloxane/glass microfluidic channel. Afterwards, selected thiophene labeled monoclonal antibodies, specific for recognition of CD4 antigens on T helper/inducer cells and CD19 antigens on B lymphocytes cell lines, were encapsulated in their active state by the immobilized microgels. When the lymphocytes suspension, containing the two target subpopulations, was flowed through the microchannel, the physiological pH of the cellular suspension induced the release of the labeled antibodies from the microgels and thus the selective cellular staining. The selective pH-triggered staining of the CD4- and CD19-positive cells was investigated in this preliminary experimental study by laser scanning confocal microscopy. This approach represents an interesting and versatile tool to realize cellular staining in a defined module of lab-on-a-chip devices for subsequent detection and counting. 相似文献
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Mariangela Palladino 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(3)
Coronavirus disease 2019 (COVID-19) pandemic represents a scientific and social crisis. One of the main unmet needs for coronavirus disease 2019 is its unpredictable clinical course, which can rapidly change in an irreversible outcome. COVID-19 patients can be classified into mild, moderate, and severe. Several haematological parameters, such as platelets, white blood cell total count, lymphocytes, neutrophils, (together with neutrophil-lymphocyte and platelet-lymphocyte ratio), and haemoglobin were described to be associated with COVID-19 infection and severity. The purpose of these review is to describe the current state of the art about complete blood count alterations during COVID-19 infection, and to summarize the crucial role of some haematological parameters during the course of the disease. Decreased platelet, lymphocyte, haemoglobin, eosinophil, and basophil count, increased neutrophil count and neutrophil-lymphocyte and platelet-lymphocyte ratio have been associated with COVID-19 infection and a worse clinical outcome. Our study adds some novelty about the identification of effective biomarkers of progressive disease, and might be helpful for diagnosis, prevention of complications, and effective therapy. 相似文献
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Sandro Calogero Mariangela Bertelle Fabrizio Antonelli Lorenzo Lazzarini 《Journal of Cultural Heritage》2000,1(4):429
57Fe Mössbauer spectroscopy permits an explanation of the formation of the iron-bearing species present in three types of coloured marbles, known as cipollino mandolato, rosso antico and fior di pesco. Structural Fe2+ and Fe3+ located in silicates, together with the remains of weakly ferromagnetic hematite, arise from primary sediments. Fe2+ located in carbonates and anti-ferromagnetic hematite are formed by redox processes during marble formation. The relative contents of the iron species in the three types of marbles depend on the composition of the primary sediments and on local conditions during metamorphism. Knowledge of the type and amount of the iron species in marbles may help in the reconstruction of the redox processes, which took place during marble formation. The deviations of the Morin transition of the hematites play the role of genetic indicator because purity, crystallinity and the red hues of hematites in marbles can be related to the environment of formation. 相似文献
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