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Sadegh Fattahi Mohammad Karimi Alivije Farhang Babamahmoodi Masomeh Bayani Mahmoud Sadeghi Haddad Zavareh Mohsen Asouri Maryam Lotfi Galia Amirbozorgi Haleh Akhavan-Niaki 《Indian journal of clinical biochemistry : IJCB》2018,33(4):467-472
Hepatitis B virus (HBV) infection is a worldwide health concern which is associated with significant morbidity and mortality. Both viral and host factors have a significant effect on infection, replication and pathogenesis of HBV. The aim of this study was to investigate the effect of CYP2E1 and CYP1A1 genetic variants on susceptibility to HBV. 143 individuals including 54 chronic HBV patients and 89 healthy controls were enrolled in the genotyping procedure. rs2031920 and rs3813867 at CYP2E1 as well as rs4646421 and rs2198843 at CYP1A1 loci were studied in all subjects using PCR–RFLP (restriction fragment length polymorphism) analysis. Both variants at CYP2E1 locus were monomorphic in all studied subjects. Genotype frequency of rs4646421 was significantly different between chronic HBV patients and healthy blood donors (P = 0.04, OR 4.31; 95% CI 1.04–17.7). Furthermore, individuals carrying at least one C allele (CC or CT genotypes) for rs4646421 seemed to have a decrease risk of hepatitis in comparison with TT genotype (P = 0.039). Our results showed a relationship between rs4646421 TT genotype (rare genotype) and the risk for developing chronic HBV infection (four times higher). Further studies are needed to examine the role of CYP1A1 polymorphism in susceptibility to chronic HBV infection. 相似文献
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Rahmatollah Fattahi 《Cataloging & classification quarterly》2018,56(4):374-384
In this article, research carried out in Iran illustrating new developments in knowledge organization is reviewed. For this purpose, all relevant studies were identified and classified into three categories: (1) studies focusing on conceptual models; (2) studies focusing on the RDA standard; and (3) studies focusing on online library catalogs (OPACs), metadata, and labeling formats related to RDA and FRBR. LIS dissertations and theses were reviewed and categorized into these three groups. The results of each research were categorized. At the end, the research methods applied in these researches were analyzed and some suggestions for further studies are proposed. 相似文献
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This paper presents a new approach to query expansion in search engines through the use of general non-topical terms (NTTs) and domain-specific semi-topical terms (STTs). NTTs and STTs can be used in conjunction with topical terms (TTs) to improve precision in retrieval results. In Phase I, 20 topical queries in two domains (Health and the Social Sciences) were carried out in Google and from the results of the queries, 800 pages were textually analysed. Of 1442 NTTs and STTs identified, 15% were shared between the two domains; 62% were NTTs and 38% were STTs; and approximately 64% occurred before while 36% occurred after their respective topical terms (TTs). Findings of Phase II showed that query expansion through NTTs (or STTs) particularly in the ‘exact title’ and URL search options resulted in more precise and manageable results. Statistically significant differences were found between Health and the Social Sciences vis-à-vis keyword and ‘exact phrase’ search results; however there were no significant differences in exact title and URL search results. The ratio of exact phrase, exact title, and URL search result frequencies to keyword search result frequencies also showed statistically significant differences between the two domains. Our findings suggest that web searching could be greatly enhanced combining NTTs (and STTs) with TTs in an initial query. Additionally, search results would improve if queries are restricted to the exact title or URL search options. Finally, we suggest the development and implementation of knowledge-based lists of NTTs (and STTs) by both general and specialized search engines to aid query expansion. 相似文献
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