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Anu Jain Sumanth Kumar Mallupattu Reetu Thakur Satyawati Mohindra Amanjit Bal Ashim Das Sushmita Ghoshal Arnab Pal 《Indian journal of clinical biochemistry : IJCB》2021,36(3):288
Cripto-1 (CR-1) is an oncofetal protein with its role as a key factor in early process of carcinoma has been evaluated in cases of various cancers. However, very few studies have reported its role in oral cancer, which is the sixth most common cancer around the world, particularly with high prevalence in developing countries. Oral squamous cell carcinoma (OSCC) is the most predominant (90%) of all the histological types of oral cancer. Late detection, associated with increased morbidity and mortality, is mainly attributed to non-availability of a suitable biomarker for the disease. In the present pilot study, we have evaluated the role of soluble CR-1, in serum as a potential tumor marker for OSCC. CR-1 was estimated using sandwich ELISA in serum samples of 50 biopsy proven OSCC patients (pre and post treatment) along with age and gender matched healthy controls. Immunohistochemistry was also done in corresponding tumor tissue sections to check the expression of CR-1. Pre-treatment CR-1 was found to be 2.25-fold higher in serum of OSCC patients as compared to control (p < 0.0001***), which was reduced to 1.6 folds post treatment (p = 0.0006***). CR-1 levels were comparatively higher in early stage of disease. Upon IHC 80% of the cases were found to be positive for CR-1. This study provides evidence that serum levels of CR-1 are elevated in patients of Oral Squamous Cell Carcinoma, which decrease post treatment. Also, the association of expression of protein with tumor progression predicts CR-1 as a molecule that can be further evaluated as a potential tumor maker in OSCC. 相似文献
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Conclusions The results of the present study seem to justify the following conclusions: (1) it is possible to identify several, relatively independent, and psychologically meaningful dimensions of the self-concept; and (2) the self-concept as measured by the Self-concept Scale functions independently of intelligence and academic aptitude as a correlate of academic achievement. Therefore, the new instriument has opotential to make an important contribution to the prediction of academic achievement. Since the istrument is only in its experimental stage, replication and cross-validation studies should be carried out to confirm the findings of the study.OISEBased mainly on Gill (1968). 相似文献
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