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Vashist SK Kaur I Bajpai RP Bharadwaj LM Tewari R Raiteri R 《Journal of Zhejiang University. Science. B》2006,7(9):683-685
We report an important observation that the surface conductivity of antibody layer immobilized on polylysine-coated glass
substrate decreases upon the formation of complex with their specific antigens. This change in conductivity has been observed
for both monoclonal and polyclonal antibodies. The conductance of monoclonal mouse IgG immobilized on polylysine-coated glass
substrate changed from 1.02×10−8 Ω−1 to 1.41×10−11 Ω−1 at 10 V when complex is formed due to the specific biomolecular interactions with rabbit anti-mouse IgG F(ab′)2. Similar behavior was observed when the same set up was tested in two clinical assays: (1) anti-Leishmania antigen polyclonal
antibodies taken from Kala Azar positive patient serum interacting with Leishmania promastigote antigen, and (2) anti-p21
polyclonal antibodies interacting with p21 antigen. The proposed concept can represent a new immunodiagnostic technique and
may have wide ranging applications in biosensors and nanobiotechnology too. 相似文献
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Arvind Kumar Poornima Tewari Sibasis S. Sahoo Arvind Kumar Srivastava 《Indian journal of clinical biochemistry : IJCB》2005,20(2):10-17
A total of 172 first degree relatives (FDRs) and 178 controls were included in this study. All the cases and controls were
subjected to various anthropometric measurements, fasting and postprandial glucose estimation, fasting insulin measurement
and fasting lipid profile. Results revealed the prevalence of Impaired Fasting Glucose (IFG) (cases 37% Vs controls 11.6%),
Impaired Glucose Tolerance (IGT) (cases 34.3% Vs controls 11.2%) and diabetes (cases 11.05% controls 3.37%) was significantly
higher in first degree relatives. Insulin resistance was measured using various methods, which included fasting plasma insulin
(FPI), Homeostasis Model Assessment for Insulin Resistance (HOMAIR), insulin sensitivity index (ISI) (Mffm/l). Prevalence of insulin resistance (Insulin Resistance) as observed comparing FPI
and HOMAIR in cases and controls was 43.6% and 11.24% (P=0.005) and 37.8% and 12.47% (P=0.000) respectively. Prevalence of IR (Insulin
Resistance) observed in cases having Normal Glucose Tolerance (NGT), Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance
(IGT) and diabetes mellitus measuring FPI Vs HOMAIR was 37.5% vs 30.2%, 45% vs 40%, 38.98% vs 37.28% and 36.84% vs 31.57% as accordingly. However, ISI (Mffm/l) was not found
to be a promising index for IR due to its poor specificity. Though HOMA is taken as gold standard for measurement of IR globally,
our study observed fasting plasma insulin representing high sensitivity (89.7%) and specificity (93.3%) as compared to HOMA.
Thus FPI had emerged in this work as a simple and reliable test for diagnosing insulin resistance across the population susceptible
to develop diabetes including FDRs. 相似文献
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Pradeep Venkatesh Garg Satpal Lalit Verma Tewari Hem Kumar Sheena Garg 《Indian journal of clinical biochemistry : IJCB》2001,16(1):9-14
Antioxidants are a small group of substances that protect living cells from the destructive consequences of powerful oxidizing
intermediates that can be formed from oxygen. Situations in which pro-oxidant mechanisms within the body are more active than
the antioxidant mechanisms (oxidative stress) predispose and contribute to the pathogenesis of several ailments in various
organs of the body. In the eye, pro-oxidant factors have been blamed for the causation of diseases such as age related macular
degeneration and senile cataract. The role of pro-oxidants in the genesis of certain diseases is well established however,
the effectivity of antioxidants provided to the body by dietary supplementation is inconclusive. In this article we provide
a review on the basic concepts of antioxidant-pro-oxidant interaction in relation to its effects on the eye. 相似文献
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V. K. Verma V. Ramesh Satyendra Tewari R. K. Gupta Nakul Sinha C. M. Pandey 《Indian journal of clinical biochemistry : IJCB》2005,20(2):68-74
A study has been carried out on 250 CAD patients to see how the serum levels of three antioxidants i.e., Vitamin C, Bilirubin
and Ceruloplasmin are related to the CAD risk factors and characteristics in these patients. The number of severe category
CAD patients declined by 7–18% with increasing serum levels of the three antioxidants and, triple vessel disease declined
by 14–20%. A decline of 39% in Myocardial Infarction (MI) occurred with increasing serum Ceruloplasmin. Serum Ceruloplasmin
was significantly lower in the MI group compared to the non MI group CAD patients. There was a steady and a significant decline
in the mean values of serum levels of cholesterol, Triglyceride, VLDL cholesterol along with BMI with increasing serum level.
The study indicates that with increasing serum levels of the three antioxidants studied, the % MI along with % Triple vessel
disease and severity of CAD goes down suggesting that the modifiable risk factors have to be suitably modified in order to
maintain a reasonably high level of these antioxidants, as the risk factors are inversely related to the serum antioxidant
levels. 相似文献
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Often knowledge management (KM) initiatives are built on an assumption that the relationship between knowledge and action starts with knowledge, that is, we know something and we act upon it. Such an assumption can lead KM initiatives to develop knowledge that is not necessarily useful for the actions that an organization is willing to take. However, if the organization derives knowledge from the actions they are willing to take or they are taking, the knowledge can be much more useful as it will directly facilitate the actions. In this article, we argue that the relationship between knowledge and action is reciprocal and offers two-way learning. As such, KM initiatives are most apt to be successful by considering how to derive knowledge from action as well as how to deliver knowledge. The paper develops five principles for action-oriented KM. 相似文献
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Arun Garg Pankaj Abrol AD Tewari Rajiv Sen Harbans Lal 《Indian journal of clinical biochemistry : IJCB》2005,20(1):85-86
Fifty children (1–4 years age) presenting with microcytic hypochromic anemia (hemoglobin less than 10g/dl) were studied in
two groups of 25 each. Group I was supplemented with iron (ferrous sulphate 6 mg/kg/d) while group II in addition to iron
was also supplemented with vitamin A (5000 IU/d). Hemoglobin concentration was found to be significantly increased after 4
weeks of iron supplementation. Rise in hemoglobin was comparatively more in-group II, as compared to group I, after 8 and
12 weeks. Serum iron was significantly higher after 4 weeks in both the groups. Packed cell volume (PCV) and retinol levels
increased significantly in-group II only. The data suggests that supplementation of vitamin A improves hematopoiesis. 相似文献
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Knowledge Management Research & Practice - The knowledge management (KM) mindset is a precursor to a knowledge-sharing culture. It is often assumed that developing a KM mindset is somewhat... 相似文献
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