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Induction of diabetes by Streptozotocin in rats 总被引：1，自引：0，他引：1
A. Akbarzadeh D. Norouzian M. R. Mehrabi Sh. Jamshidi A. Farhangi A. Allah Verdi S. M. A. Mofidian B. Lame Rad 《Indian journal of clinical biochemistry : IJCB》2007,22(2):60-64
The objective of this study is to induce experimental diabetes mellitus by Streptozotocin in normal adult Wistar rats via
comparison of changes in body weight, consumption of food and water, volume of urine and levels of glucose, insulin and C-peptide
in serum, between normal and diabetic rats. Intra-venous injection of 60mg/kg dose of Streptozotocin in adult wistar rats,
makes pancreas swell and at last causes degeneration in Langerhans islet beta cells and induces experimental diabetes mellitus
in the 2–4 days. Induction of experimental diabetes mellitus is indeed the first step in the plan of purification of pancreatic
Langerhans islet cells of normal rats for transplanting under the testis subcutaneous of experimentally induced diabetic rats.
Streptozotocin induces one type of diabetes which is similar to diabetes mellitus with non-ketosis hyperglycemia in some animal
species. For induction of experimental diabetes in male adult rats weighted 250–300 grams (75–90 days), 60mg/kg of Streptozotocin
was injected intravenously. Three days after degeneration of beta cells, diabetes was induced in all animals. The diabetic
and normal animals were kept in the metabolic cages separately and their body weight, consumption of food and water, urine
volume, the levels of serum glucose, insulin and C-peptide quantities in all animals were measured and then these quantities
were compared. For a microscopic study of degeneration of Langerhans islet beta cells of diabetic rats, sampling from pancreas
tissue of diabetic and normal rats, staining and comparison between them, were done. Induction of diabetes with Streptozotocin
decreases Nicotinamide-adenine dinucleotide (NAD) in pancreas islet beta cells and causes histopathological effects in beta
cells which probably intermediates induction of diabetes. In this study, we used Streptozotocin for our experiments in induction
of experimental diabetes mellitus. After Induction of diabetes, consumption of food and water, volume of urine and glucose
increased in the diabetic animals in comparison with normal animals, but the weight of body and the volume of insulin and
C-peptide decreased in the diabetic animals. Sampling and staining of pancreas tissue of diabetic and normal rats showed that
the Langerhans islet beta cells of diabetic rats have been clearly degenerated. In three days, Streptozotocin makes pancreas
swell and at last causes degeneration in Langerhans islet beta cells and induces experimental diabetes. It also changes normal
metabolism in diabetic rats in comparison with normal rats. Consumption of water and food, volume of urine, serum glucose
increases in diabetic animals in comparison with normal rats but the levels of serum insulin, C-peptide and body weight decreases. 相似文献
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Sultana S. Zaman Shirin Z. Munir 《International Journal of Disability, Development & Education》1992,39(1):3-11
SPECIAL EDUCATION in Bangladesh reflects the overall educational problems faced by the nation. While some government programs for children with sensory disabilities are provided, most special education is supported by non‐government organizations. Though planning for improved special education has occurred, implementation has been restricted by economic constraints. 相似文献
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We obtained data on the writing of 110 deaf or hard-of-hearing students attending public schools who completed the spontaneous writing portion of the Test of Written Language. The average written quotient for the sample was in the below-average range but within 1 standard deviation of the test mean. Forty-nine percent of the sample received written quotients within or above the average range. Mean scores for the three subtests of contextual conventions, contextual language, and story construction were within the low-average range; between 55% and 68% of students scored within the average or above-average range for the subtests. Predictors of writing quotients were eligibility for free lunch, grade, degree of hearing loss and gender; however, only 18% of the variance in total writing quotients was explained by these variables. The data indicate that attention needs to be paid to the writing ability and instruction of many public-school students regardless of degree of hearing loss. 相似文献
5.
A. Akbarzadeh D. Noruzian Sh. Jamshidi A. Farhangi M. R. Mehrabi B. Lame Rad M. Mofidian A. Allahverdi 《Indian journal of clinical biochemistry : IJCB》2007,22(1):71-76
Insulin injection is the main way to combat against insulin-dependent diabetes mellitus effects. Today in some laboratories
in the world, the investigators are trying to find some treatments for this disease with insulin-secreting pancreatic islet
cells transplantation. Donor tissue in each step of work was prepared from 36 adult male wistar Rats weighted 250–300 grams
(75–90 days). Transplantation was done in rats after 2–4 weeks induction of diabetes with 60mg/kg of streptozotocin injection
by intravenous method. Encapsulation of pancreatic islet cells allows for transplantation in the absence of immunosuppression.
This technique that is called “immunoisolation” is based on the principle that transplanted tissue is protected for the host
immune system by an artificial or natural membrane. In this study, the levels of insulin, C-peptide and glucose in diabetic
rats have been reached to normal range as compared to un-diabetic rats in 20 days after transplantation of islet cells, so
that testis is immunoisolated place for islet cells transplantation. Inside the testis subcutaneously and intrapretoneally
implantation of pure islet cells graft, that is a natural immunoisolation method, rapidly and permanently normalized the diabetic
state of streptozocin-administered animals. 相似文献
6.
Aubteen Darabi Shirin Pourafshar Rinki Suryavanshi Thomas ‘Logan’ Arrington 《International Journal of Science Education》2016,38(7):1197-1211
This study examines the performance of dietitians-in-training on developing a diet plan for a diabetic patient either independently or after peer discussion. Participants (n?=?58) from an undergraduate program in food and nutrition were divided into two groups based on their prior knowledge before being randomly assigned into three conditions: (1) peer discussion with just-in-time information (JIT information), (2) peer discussion without JIT information), and (3) independent performers. The learners’ performance in the three conditions was analyzed. The results presented here describe the role of prior knowledge and JIT information across the conditions and the interaction of the two factors as well as the instructional implications of the findings. 相似文献
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This article offers a variety of culturally responsive approaches and activities so as to better know and understand our students' diverse cultural and linguistic backgrounds. These methods will not only help to make more equitable classrooms where we make meaningful connections with our students—but also yield useful data so as to inform our yearly curriculum and instruction. 相似文献
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While much has been written about marginalization as a structural phenomenon, there is little understanding of how the dynamics of marginalization unfold at the micro level in urban contexts. We seek to understand these micro-level marginalization processes via a comparative study of Bangalore, India, and Ronneby, Sweden. Our analysis highlights the important role that “mediators” such as governmental agencies, nongovernmental organizations (NGOs), and international agencies play in ensuring the success of initiatives launched by national governments and international agencies for drawing disadvantaged groups into the information society. 相似文献
9.
Bass Kristin M. Hu Dahl Ingrid Panahandeh Shirin 《Journal of Science Education and Technology》2016,25(6):1009-1024
Journal of Science Education and Technology - Numerous studies have indicated a need for a diverse workforce that is more highly educated in STEM and ICT fields, and one that is capable of... 相似文献
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ABSTRACT Eleanor Leacock (1922–1987) was a cultural anthropologist and prominent critic of the “culture of poverty” framework. This paper analyzes Leacock’s writings on the culture of poverty with the following questions in mind: How did Leacock’s critique of the culture of poverty framework evolve over time? What was her dissatisfaction with the available conceptual vocabulary and how was she struggling to grow beyond it? We illustrate the shift in Leacock’s critique of culture of poverty discourses by juxtaposing key writings from 1960 and 1980. We then offer an interpretation of the shift by discussing four central themes across her work: the we–they dichotomy, definitions of culture, a critique of research methods, and the real-world effects of the culture-of-poverty thesis. We conclude by drawing insights from the evolution of Leacock’s thinking to advance a critique of contemporary culture of poverty discourses, and to help develop an alternative conceptual vocabulary. 相似文献