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Simmi Kharb Manjulata Kumawat Meenakshi Lallar P. S. Ghalaut Smiti Nanda 《Indian journal of clinical biochemistry : IJCB》2017,32(1):95-98
HIV infects cluster of differentiation 4 (CD4) T-lymphocytes, monocytes and macrophages resulting in decreased number and function of CD4 cells, changes that affect both cell mediated and humoral immunity. Hematological abnormalities are a common complication of human immune virus (HIV) infection and these abnormalities increase as the disease advances. Anemia is the most common haematological abnormality in HIV seropositive patients and its incidence is strongly associated with the progression of the disease. The aim of present study was to assess the haematological profile of HIV seropositive women and compare them with CD4 count. Two hundred seropositive females (age 18–25 years) attending antiretroviral therapy clinic were selected. Routine gynaecological and haematological investigations were carried out, study samples were drawn and serum iron, folate and ferritin were analysed by chemiluminiscence and CD4 count was determined by using flow-cytometry. Anemia was prevalent in seropositive women especially in those with low CD4 levels. Serum folate and ferritin levels were significantly lower in females with lower CD4 levels. Serum iron levels were higher at low CD4 levels. The mean CD4 count in HIV seropositive anaemic women were lower as compared to non anaemics suggesting that anaemia improves with higher CD4 cell counts. Plasma folate and ferritin levels are sensitive predictor of anaemia in early HIV infections and these patients should have a regular monitoring of their folate and ferritin levels especially with lower CD4 levels. 相似文献
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Kiran Dahiya A. D. Tiwari Vijay Shankar Simmi Kharb Rakesh Dhankhar 《Indian journal of clinical biochemistry : IJCB》2006,21(1):157-160
Phototherapy has been related to increased oxidative stress and lipid peroxidation. In the present study, thirty full term
jaundiced neonates with appropriate weight were analyzed before and after completion of phototherapy for malondialdehyde (MDA),
reduced glutathione (GSH), total thiols, vitamin C and superoxide dismutase (SOD) levels in hemolysate and albumin levels
in plasma. These parameters were analyzed in cord blood samples of 20 healthy neonates as control. It was observed that levels
of MDA were elevated significantly (p<0.001) in patients as compared to controls and that the levels increased significantly
after phototherapy (p<0.001). Levels of SOD were also found to be increased significantly as compared to controls and the
levels rose after phototherapy (p<0.001). On the other hand, the levels of non-enzymatic antioxidants such as GSH, total thiols
and vitamin C were significantly low (p<0.001) as compared to controls and the levels decreased significantly after phototherapy
(p<0.001). The plasma albumin levels also were found to be decreased significantly after phototherapy (p<0.01). Therefore,
phototherapy increases oxidative stress and should be used with care. 相似文献
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Anjali Sharma Simmi Kharb Vineeta Nirmal Gulati 《Indian journal of clinical biochemistry : IJCB》1998,13(2):123-125
The present study revealed significantly lower levels of serum magnesium in patients with preterm labour without any apparent
cause as compared to normal term pregnant women in labour. The values were also lower in women with low socioeconomic status,
older age and consuming vegetarian diet. Hence, estimation of serum magnesium levels in pregnancy may be a useful parameter
in preterm labour. 相似文献
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Conclusion Available evidence suggests that we can not dismiss the potential value of nutriceuticals in disease and inhibition of atherosclerosis.
Epidemiologic data suggest that antioxidant supplementation may be associated with a reduced risk of clinical events from
atherosclerosis; howere, interventional trials only support a role for vitamin E in this regard. Many studies suggest that
a link between fruit and vegetables in diet or the amounts of plasma antioxidant vitamins (ascorbic acid, tocopherols and
carotenoids) and risk of death from cancer or coronary heart disease. The usefulness of antioxidant for prevention of cardiovascular
disease is yet to be proven. However, studies offer important insights that together with the development of methods to identify
individuals most likely to benefit, provide hope to clinicians seeking to use antioxidant vitamins with safety and efficacy
for the treatment and prevention of cardiovascular disease. Only continued investigation into the mechanism (s) of action
of candidate agents will determine whether they hold promise as a therapeutic intervention and only then, they can be recommended
routinely to the patients. Thus, nutriceuticals are becoming more widely accepted as an adjunct to conventional therapies. 相似文献
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