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Krishnan Gokuladhas Subramaniyan Jayakumar Balan Rajan Ramasamy Elamaran Chengalvarayan Subramani Pramila Mani Gopikrishnan Sasivarman Tamilarasi Thiruvengadam Devaki 《Indian journal of clinical biochemistry : IJCB》2016,31(2):171-184
Liver cancer is the fifth most common cancer and is still one of the leading causes of death world wide, due to food additives, alcohol, fungal toxins, air, toxic industrial chemicals, and water pollutants. Chemopreventive drugs play a potential role in liver cancer treatment. Obviously in the production of anticancer drugs, the factors like poor solubility, bioavailability, biocompatibility, limited chemical stability, large amount of dose etc., plays a major role. Against this backdrop, the idea of designing the chemopreventive nature of bio flavanoid hesperetin (HP) drug conjugated with pegylated gold nanoparticles to increasing the solubility, improve bioavailability and enhance the targeting capabilities of the drug during diethylnitrosamine (DEN) induced liver cancer in male wistar albino rats. The dose fixation studies and the toxicity of pure HP and HP conjugated gold nanoparticles (Au-mPEG(5000)-S-HP) were analysed. After concluded the dose fixation and toxicity studies the experimental design were segregated in six groups for the anticancer analysis of DEN induced HCC for 16 weeks. After the experimental period the body weight, relative liver weight, number of nodules and size of nodules, the levels of tumor markers like CEA, AFP and the level of lipid peroxidation, lipid hydroperoxides and the activities of antioxidant enzymes were assessed. The administration of DEN to rats resulted in increased relative liver weight and serum marker enzymes aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and gamma glutamyl transpeptidase. The levels of lipid peroxides elevated (in both serum and tissue) with subsequent decrease in the final body weight and tissue antioxidants like superoxide dismutase, catalase, reduced glutathione, glutathione peroxidise, and glutathione reductase. HP supplementation (20 mg/kg b.wt) significantly attenuated these alterations, thereby showing potent anticancer effect in liver cancer and the HP loaded gold nanoparticels (Au-mPEG(5000)-S-HP) treated animals shows the better treatment than the pure HP due to the solubility of drug, bioavailability and the target drug delivery of the biodegradable polymer. Histological observations were also carried out, which added supports to the chemopreventive action of the pure HP and HP loaded gold nanoparticles (Au-mPEG(5000)-S-HP) against DEN induction during liver cancer progression. These findings suggest that HP loaded gold nanoparticels (Au-mPEG(5000)-S-HP) shows better efficacy than the pure HP against lipid peroxidation, hepatic cell damage and protects the antioxidant system in DEN induced hepatocellular carcinogenesis. 相似文献
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Raghuraman Sivalingam Subramani Chinnamuthu Subhransu Sekhar Dash 《Journal of The Franklin Institute》2017,354(12):4762-4783
This paper proposes to use a hybrid Stochastic Fractal Search (SFS) and Local Unimodal Sampling (LUS) based multistage Proportional Integral Derivative (PID) controller consisting of Proportional Derivative controller with derivative Filter (PDF) plus (1 + Proportional Integral) for Automatic Generation Control (AGC) of power systems. Initially, a single area multi-source power system consisting of thermal hydro and gas power plants is considered and parameters of Integral (I) controller is optimized by Stochastic Fractal Search (SFS) algorithm. The superiority of SFS algorithm over some recently proposed approaches such as optimal control, Differential Evolution (DE) and Teaching Learning Based Optimization (TLBO) is demonstrated. To improve the system performance further, LUS is subsequently employed. The study is further extended for different controllers like PID, and proposed multistage PID controller and the superiority of multistage PID controller over conventional PID controller structure is demonstrated. The study is further extended to a two-area six unit multi-source interconnected power system and the superiority of proposed approach over, TLBO and optimal control is demonstrated. Finally the study is extended to a three unequal area system power system with appropriate nonlinearities such as Generation Rate Constraint (GRC), Governor Dead Band (GDB) and time delay. From the analysis, it is found that hybrid SFS–LUS algorithm is superior to the original SFS algorithm and substantial improvement in system performance are realized with proposed multistage PID controller over conventional PID controller structure. 相似文献
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