Lipid Parameters, Doses and Blood Levels of Calcineurin Inhibitors in Renal Transplant Patients     

Hayriye Senturk Ciftci  Tulay Kilicaslan Ayna  Yasar Kerem Calıskan  Aydin Turkmen  Mehmet Gurtekin 《Indian journal of clinical biochemistry : IJCB》2013,28(2):164-168

The calcineurin inhibitors (CNIs) [cyclosporin A (CsA) and tacrolimus (Tac)] are currently the most widely prescribed drugs for maintenance of immunosuppression after renal transplantation. These immunosuppressants are associated with side effects such as hyperlipidemia. We evaluated the differential effects of different CNIs on serum lipid parameters in renal transplant patients. Moreover, the aim of this study is to investigate the relationships between doses and blood levels of CNIs, and blood levels of CNIs and lipid parameters retrospectively. Two groups of 98 non-diabetic renal transplant patients, each treated with different CNIs, were studied: group A (n = 50, mean age: 31 ± 10 years), CsA, mycophenolate mofetil/azathioprin, steroid; group B (I = 48, mean age: 34 ± 12 years), Tac, mycophenolate mofetil/azathioprin, steroid. In renal transplant patients, CNIs blood levels and doses were examined at 1, 3, 6, 9, and 12 months after transplantation. Biochemical laboratory parameters including plasma lipids [total-cholesterol (CHOL), low-density lipoprotein (LDL)–CHOL, high-density lipoprotein (HDL)–CHOL, and triglycerides (TG)], CNI levels and doses were examined at 1, 3, 6, 9, and 12 months after transplantation. None of the patients received anti-lipidemic drugs during the study period. Blood levels of CNIs were detectable in all whole-blood samples by Cloned- Enzyme-Donor Immunoassay (CEDIA). The relationship between CNIs blood levels and CHOL, (LDL)–CHOL, HDL–CHOL, TG were evaluated. The mean serum CHOL levels and LDL–CHOL levels of patients in group A were found significantly higher than the patients in group B during the 12 month of follow up (p < 0.05). There was no significant difference in TG and HDL–CHOL plasma levels between group A and group B (p > 0.005). In group A the daily dose of CsA was significantly correlated with the mean blood levels of CsA at the 1st and 3rd months (r = 0.387, p = 0.005; r = 0.386, p = 0.006), respectively. In group A, the daily dose of CsA was significantly correlated with the mean serum TG levels during the 12 month of follow up (r = 0.420, p = 0.003). In group B, the daily dose of Tac was significantly correlated with the mean blood level of Tac (r = 0.335, p = 0.020) at the 1st month. No correlation was found between mean Tac blood levels and lipid parameters during the 12-month of follow up (p > 0.05). Significant positive correlation was observed between the CsA blood levels and LDL–CHOL levels (r = 0.338, p = 0.027) at the 3rd month. In the renal transplant patients with well functioning grafts, CsA therapy is associated with increased CHOL and LDL–CHOL ratio which represents an increased atherogenic risk tended to be associated with CsA. Serum LDL–CHOL levels may be effected by blood CsA levels.  相似文献   

TURKISH AND U.S. ATTITUDES TOWARD AGING     

Jasmin Tahmaseb McConatha  Vildan Hayta  Loretta Rieser-Danner  Douglas McConatha  Tulay S. Polat 《Educational gerontology》2013,39(3):169-183

As people live longer and the number of older adults increases worldwide, it becomes important to understand the factors that influence how we understand and perceive our own aging as well as how we construct our attitudes toward older adults. Although studies have indicated that later adulthood can be a healthy, productive, and satisfying time of life, ageism or prejudice and discrimination against older adults and a fear of the aging process, continues to be a widespread phenomena. The purpose of this study was to compare attitudes and anxieties toward aging of young and middle-aged men and women from the United States and Turkey. The results indicate that significant country and gender differences exist in how people feel about getting older and the age at which they consider themselves to be “old.” Contact with elders as well as education regarding the process of aging appear to have a significant impact on attitudes toward aging.  相似文献   

The new Turkish early childhood teacher education curriculum: a brief outlook     

Tulay Atay-Turhan  Yusuf Koc  Mine Isiksal  Huseyin Isiksal 《Asia Pacific Education Review》2009,10(3):345-356

This article aims to describe and reflect on the new early childhood teacher education curriculum in Turkey. The new curriculum is part of a large-scale reform agenda to improve education at all levels. The article begins with a brief history of early childhood education and early childhood teacher education in Turkey. Then, the needs for the curriculum revision and major characteristics of the revised curriculum are discussed. The article concludes with brief discussion about the innovations and suggestions for future research dealing with the implementation and effectiveness of the revised curriculum  相似文献