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How does the human body defend itself, and why does it choose the paths it does choose? 相似文献
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How does the immune system make sure that the assorted recognition keys it cuts for itself do not open the wrong doors and cause self-inflicted disease? How Does the Immune System Weed the Developing Repertoire? 相似文献
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R. S. Sharma K. K. Gaur P. C. Pal Monika Manocha Deepak Tomar Arif Azam Khan Vinita Tripathi Vineeta Chattree A. Kriplani 《Indian journal of clinical biochemistry : IJCB》2005,20(1):173-183
Progress in diagnosis of infertility, has been dramatically increased during the past decades with changes occurring in virtually
all aspects of infertility research, thus providing innovative diagnostic testing and sophisticated instrumentation for improved
management and treatment of infertility. There are about 50% of infertile couples who are suffering because of male infertility.
Semen examination is a basic investigation for these infertile couples. It not only reveals the quantity and quality of sperm
but also the quality of the seminal plasma, which is essential for normal sperm function. In this review, the recent advancement
in investigation procedures has been analyzed which are very important in clinical practice to (a) evaluate the sperm fertilizing
ability (Acrosin, aniline blue, HOS), (b) characterization of male accessory sex glands secretions (Fructose, alpha-glucosidase,
PSA) and (c) the management of azoospermic patients. It is believed that use of such diagnostic procedures will facilitate
wide selection of patients for whom an effective therapy might be then possible. 相似文献
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D Tomar V Chattree V Tripathi A A Khan A R Bakshi D N Rao 《Indian journal of clinical biochemistry : IJCB》2005,20(1):213-230
The development of vaccines to prevent infectious diseases has been one of the most important contributions of biomedical
sciences. Increasing understanding in biochemistry, molecular biology, molecular genetics and related fields have provided
an opportunity for the development of new generation vaccines that are based on rational design approaches. This is possible
because of proper understanding of the microbial-genetics, biochemistry, host-pathogen interaction and recent developments
in molecular immunology. Another important improvement made in the quality of vaccine production is the incorporation of immunomodulators
or adjuvants with modified delivery vehicles viz liposomes, Iscoms and microspheres apart from alum being used as a gold standard.
This article reviews the art of vaccination from Jenner period to present day context highlighting all the developments made
at each stage of the vaccine development. Various criteria have been discussed regarding the selection of epitopes that expand
B & T cells, its linkage with other accessory cells of the immune system, means to overcome MHC linked immune unresponsiveness,
enhanced antigen processing and presentations that specially induce either helper or cytotoxic or mucosal immune responses
were critically discussed. 相似文献
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How is the immune system designed to choose between making antibodies against some targets, killer cells against viral infections and helper cells for infected macrophages? 相似文献
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Parasites use different strategies for successful invasion. So what are the responses that the immune system must tailor-make for these strategies? 相似文献
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Anjali Sharma Simmi Kharb Vineeta Nirmal Gulati 《Indian journal of clinical biochemistry : IJCB》1998,13(2):123-125
The present study revealed significantly lower levels of serum magnesium in patients with preterm labour without any apparent
cause as compared to normal term pregnant women in labour. The values were also lower in women with low socioeconomic status,
older age and consuming vegetarian diet. Hence, estimation of serum magnesium levels in pregnancy may be a useful parameter
in preterm labour. 相似文献
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