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Herman S D'Souza Geraldine Menezes T Venkatesh 《Indian journal of clinical biochemistry : IJCB》2002,17(1):1-4
Our study aimed at comparing lead and zinc protoporphyrin (ZPP) levels in capillary and venous blood samples in a small population
and to employ an easier method of sample collection for a major screening program in school children in major Indian cities.
An awareness program on lead and its effects was conducted in two different schools. A total of thirty urban school children
from South India, with an age group between 4–12 years consented for dual blood sampling and reported for the study. Venous
and capillary blood samples were obtained simultaneously. Blood lead and zinc protoporphyrin (ZPP) levels were estimated using
ESA Lead Analyzer and Haematofluorometer respectively. A significant correlation between capillary and venous ZPP (r=0.98)
and lead (r=0.99) was observed. Rank sum test showed that there is no statistically significant difference between capillary
and venous ZPP (P=0.891) and lead (P=0.672) values. This pilot study recommends that screening for lead may be done using
capillary blood samples since significant correlation is observed between capillary and venous blood measurements. Obtaining
samples using this mode is a non-invasive, less expensive, quick and easy method in children. Appropriately performed capillary
sampling may be considered as an acceptable alternative to venipuncture for screening of blood for lead poisoning both in
children and adults. 相似文献
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Bhanu P. Singh Banani Banerjee Puspanita Naik Jordan N. Fink Viswanath P. Kurup 《Indian journal of clinical biochemistry : IJCB》2006,21(2):20-27
The ubiquitous fungus Aspergillus fumigatus causes allergic rhinitis, asthma, sinusitis and allergic bronchopulmonary aspergillosis.
A number of major allergens from A. fumigatus are purified, but their structure-function role in the pathogenesis of disease
is not known. Such information is essential for devising alternative therapy of fungal allergic diseases. In the present study,
N-terminal and C-terminal deletion mutants ofAsp f 3 were constructed and their immunopathological responses studied in a mice model of allergy. Three mutants viz,Asp f 3 (aa 33–168), (aa 1–142), and (aa 23–142) were made by deleting certain amino acids from epitopic regions of full lengthAsp f 3, a major allergen of A. furnigatus. TheAsp f 3 and three mutated proteins were expressed in pET vector. The C-terminal deletion mutantAsp f 3 (aa 1–142) induced elevated IFN-γ but low levels of IL-4 by spleen cells. This mutant also showed significant downregulation
of peripheral blood eosinophils and lung inflammation in immunized mice. The N-terminal deletion mutantAsp f 3 (aa 33–168) also exhibited an immuno-suppressive effect in terms of IgE production and induction of Th2 cytokine. The results
indicate thatrAsp f 3 and its deletion mutants induced distinct immune-inflammatory responses in mice on challenge with these proteins. The non-IgE
binding deletion mutants ofAsp f 3 (aa 1–142 and aa 33–168) could deviate Th2 immune response with a concomitant reduction in airway inflammation and infiltration
of inflammatory cells. 相似文献
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Pillai K. R. Upadhyaya Pallavi Prakash Ashish Viswanath Ramaprasad Badrinarayan Srirangam Mukesh H. V. Pai Yogesh 《Education and Information Technologies》2021,26(4):3677-3698
Education and Information Technologies - The current study examines students’ coping process of a forced technological intervention in academic outcome assessment in a higher education... 相似文献
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Understanding disease transmission is a complex problem highlighted by the COVID-19 pandemic. These studies test whether 3- to 6-year-old children in the United States use information about social interactions to predict disease transmission. Before and during COVID-19, children predicted illness would spread through close interactions. Older children outperformed younger children with no associations between task performance and pandemic experience. Children did not predict that being hungry or tired would similarly spread through close interactions. Participants include 196 three- to six-year-olds (53% girls, 47% boys; 68% White, 9% Black, 7% Asian, 6% Hispanic or Latinx), with medium-sized effects (d = .6, = .3). These findings suggest that thinking about social interaction supports young children's predictions about illness, with noted limitations regarding children's real-world avoidance of disease-spreading behaviors. 相似文献
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Sultana Furruqh D. Anitha T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2004,19(2):72-79
Reference intervals in clinical chemistry are commonly based on results of measurements in reference western population or
are taken from the western literature. Reference Values are thought to aid physicians to interpret results of measurements
and, should be representative of a defined group of individuals. This group should be as similar as possible to the patients
under investigation. The reference population in this, study has been recruited from the individuals attending the Health
Plan Clinic who fulfill the defined inclusion and exclusion criteria as well as defined partition criteria. The samples were
sorted based on the decision by the physician. The emerging group of individuals was considered as a reference population
for the hospital patients and the results of measurements in this study was evaluated statistically, to stress on the urgent
need to establish the in-house reference values. The reference limits are defined as the central 95 percentile of the population
after eliminating the outliers. The lower, reference limit is the 2.5 percentile while the upper reference limit constituted
the 97.5 percentile for the population. 相似文献
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Anita R. Bijoor S. Geetha T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2004,19(2):20-22
Malabsorption syndromes causing steatorrhoea are quite common in India. Estimation of faecal fat is an important non-invasive
investigation, which provides vital information regarding the occurrence of malabsorption. The aim of this study was to estimate
the fat excretion per day in stools of apparently healthy adults on an unrestricted diet in random spot stool samples using
the Acid Steatocrit Method, which provides an alternate, simpler and yet reliable method of stool fat estimation. Several
studies have proved the correlation of the acid steatocrit method with the conventional methods. In India, however, there
has been no published data regarding the normal levels of fat in the stools, by the acid steatocrit method. We follow the
normal range values, as set by the United States and the European countries, not having a range for the Indian population.
Hence, we took up a preliminary study, to estimate stool fat in a section of normal and healthy Indian population. The result
obtained after screening 600 healthy and normal adults, showed the mean of stool fat to be 8.72 gms/24 hours, which is much
higher than that, defined by Western literature (7 gms/24 hours). This can be accounted for, by the cultural and ethnic variations
in dietary and food habits. Further studies are required in the same direction, involving larger population groups, and in
different malabsorptive conditions. 相似文献
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Raviraja A Vishal Babu GN Sehgal A Saper RB Jayawardene I Amarasiriwardena CJ Venkatesh T 《Indian journal of clinical biochemistry : IJCB》2010,25(3):326-329
Ayurveda is a traditional form of medicine used by majority of the Indians. Here we report three cases of lead toxicity, following
intake of Ayurvedic medicines. Three patients presented with blood lead levels (BLLs) of 122.4, 115 and 42.8 μg/dl respectively
at the time of hospitalization. The first case was chelated with D- penicillamine, the second with calcium disodium ethylene
diamino tetra acetate (EDTA) and the third with environmental intervention and education. Associated Ayurvedic products were
collected from patients and analyzed for metallic concentration. Cessation of Ayurvedic medication along with chelation, nutritional
intervention and education, reduced the BLL to 27.4 μg/dl in the first case after 1 year, 21.1 μg/dl after 9 months in the
second and 18.2 μg/dl after 6 months in the third case. 相似文献