Short-term memory for order but not for item information is impaired in developmental dyslexia     

Wibke M. Hachmann  Louisa Bogaerts  Arnaud Szmalec  Evy Woumans  Wouter Duyck  Remo Job 《Annals of dyslexia》2014,64(2):121-136

Recent findings suggest that people with dyslexia experience difficulties with the learning of serial order information during the transition from short- to long-term memory (Szmalec et al. Journal of Experimental Psychology: Learning, Memory, & Cognition 37(5): 1270-1279, 2011). At the same time, models of short-term memory increasingly incorporate a distinction of order and item processing (Majerus et al. Cognition 107: 395-419, 2008). The current study is aimed to investigate whether serial order processing deficiencies in dyslexia can be traced back to a selective impairment of short-term memory for serial order and whether this impairment also affects processing beyond the verbal domain. A sample of 26 adults with dyslexia and a group of age and IQ-matched controls participated in a 2?×?2?×?2 experiment in which we assessed short-term recognition performance for order and item information, using both verbal and nonverbal material. Our findings indicate that, irrespective of the type of material, participants with dyslexia recalled the individual items with the same accuracy as the matched control group, whereas the ability to recognize the serial order in which those items were presented appeared to be affected in the dyslexia group. We conclude that dyslexia is characterized by a selective impairment of short-term memory for serial order, but not for item information, and discuss the integration of these findings into current theoretical views on dyslexia and its associated dysfunctions.  相似文献   

Gamma heavy chain disease in a patient with rheumatoid arthritis – a laboratory evaluation     

Wibke Johannis  Jenny Blommer  Andreas R. Klatt  Joerg H. Renno  Klaus Wielckens 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(3):373-379

Introduction:

Heavy chain diseases (HCD) are neoplastic proliferations of B cells which secrete truncated immunoglobulin heavy chains without associated light chains. Being rare and probably underdiagnosed diseases the aim of this report is to show an additional case of gamma heavy chain disease in a 48 year old female patient with rheumatoid arthritis focusing on the laboratory presentation.

Materials and methods:

Laboratory work-up included agarose gel electrophoresis (AGE), capillary zone electrophoresis (CZE), immunofixation and nephelometrically determined immunoglobulin and immunoglobulin subclasses of the patient’s serum. Urine samples were also subjected to immunofixation and to a SDS-PAGE with consecutive immunoblot.

Results:

Nephelometrically measured elevated IgG concentrations were noted in combination with a decreased gamma globulin region and an increased beta globulin region on AGE. A definite monoclonal spike was not identified on AGE but at least suspected on CZE; finally serum and urine immunofixation demonstrated a monoclonal gamma heavy chain devoid of any corresponding light chains confirming the diagnosis of HCD. Analysis of the gamma heavy chain (HC) with means of SDS-PAGE revealed proteins of 40 kD and 80 kD most likely presenting a truncated HC in its monomeric and dimeric form and possibly leading to the failure of IgG-subclass typing with the applied IgG subclass antisera.

Conclusion:

This case report illustrates a new case of gamma HCD demonstrating variable laboratory manifestations and therefore the need for heightened awareness concerning this disease when confronted with abnormal and discrepant protein profiles in routinely applied laboratory tests.  相似文献   

Developmental surface and phonological dysgraphia in German 3rd graders     

Jürgen Cholewa  Stefanie Mantey  Stefanie Heber  Wibke Hollweg 《Reading and writing》2010,23(1):97-127

The investigation of developmental reading and spelling disorders within the framework provided by cognitive neuropsychology has yielded interesting results for several alphabetic orthographies, for example English, Italian, and French. However, this approach has not attracted much attention in German speaking countries up to now. The following study, carried out with 35 German dysgraphic 3rd graders provides evidence that there is no less reason to apply this line of research to German children than to children acquiring other alphabetic orthographies. By evaluating the individual scores of the dysgraphic children on spelling nonwords and orthographically irregular or inconsistent words against the corresponding mean scores established for two non-dysgraphic control samples (grade-matched and 2nd grade), nine children could be assigned to the surface dysgraphic and 12 to the phonological dysgraphic subtype. In order to restrict the range of cognitive deficits which might have caused the spelling patterns of the two dysgraphic subgroups at more distal links of the causal chain, individual performance profiles were determined for several spelling-related phonological and visual-graphemic tasks. On average, the phonological dysgraphic children showed poorer performance in different phonological tasks than the children assigned to the surface subtype. In addition, both subgroups showed subnormal skills in visual-graphemic tasks. Dissociations between the different spelling related tasks were observed not only between but also within the subgroups. This may reflect individually varying cognitive processing deficits underlying developmental dysgraphia in German.  相似文献