排序方式： 共有6条查询结果，搜索用时 15 毫秒
1
1.
Yoshihiro Okamoto Tomoyo Mita Testuri Kodama Yoshimitsu Gotoh Naoya Fujita Takashi Fukui Toshiyuki Masuzawa 《Indian journal of clinical biochemistry : IJCB》2015,30(3):351-356
We measured serum soluble vascular endothelial growth factor receptor 1 (sVEGFR1) and receptor 2 (sVEGFR2) levels in healthy Japanese individuals in order to establish a reference value using a specific ELISA. Significant differences were observed in serum sVEGFR1 and sVEGFR2 levels between children and adults. To demonstrate the usefulness of the reference value for children, we measured serum sVEGFR1 and sVEGFR2 levels in children with diarrhea positive (D+) hemolytic uremic syndrome (HUS) as a preliminary study. Serum sVEGFR2 levels in children with HUS were markedly higher than those in healthy children from the onset of D + HUS. The reference value for healthy children in the present study will allow normal and pathological conditions to be discriminated from each other in future study 相似文献
2.
3.
Iida H Kato S Sekino Y Sakai E Uchiyama T Endo H Hosono K Sakamoto Y Fujita K Yoneda M Koide T Takahashi H Tokoro C Goto A Abe Y Kobayashi N Kubota K Gotoh E Maeda S Nakajima A Inamori M 《Journal of Zhejiang University. Science. B》2012,13(1):29-34
Objective
The ideal medication for the treatment of acid-related diseases, e.g., peptic ulcers, stress-related gastric bleeding, functional dyspepsia, and gastroesophageal reflux disease, should have a rapid onset of action to promote hemostasis and relieve the symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor, omeprazole 20 mg, and an H2-receptor antagonist, roxatidine 75 mg.Methods
Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg. Each administration was separated by a 7-d washout period.Results
During the 6-h study period, the average pH after administration of roxatidine was higher than that after administration of omeprazole (median: 4.45 vs. 2.65; P=0.0367). Also during the 6-h study period, a longer duration of maintenance at pH above 2, 5, and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg (median: 90.6% vs. 55.2%, P=0.0284; 43.7% vs. 10.6%, P=0.0125; 40.3% vs. 3.3%, P=0.0125; respectively).Conclusions
In Helicobacter pylori-negative healthy male subjects, oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg. 相似文献4.
Hirofumi Shimojo Rio Nara Yasuhiro Baba Hiroshi Ichikawa Yusuke Ikeda Yoshimitsu Shimoyama 《Journal of sports sciences》2013,31(20):2339-2346
ABSTRACTAnkle flexibility is critical to obtain a high swimming velocity in undulatory underwater swimming (UUS). The present study investigated the Froude (propelling) efficiency and three-dimensional (3D) kinematics of human UUS following the extrinsic restriction of the ankle by tape application. In Experiment 1, swimmers (9 male and 8 female college swimmers) performed UUS trials involving normal swimming (Normal) and swimming with tape application at the ankle (Tape). Kicking frequency was controlled in both settings. UUS kinematics were obtained with a two-dimensional motion analysis. Swimming velocity significantly decreased during swimming with tape application compared with that during normal swimming (Normal, 1.33 m·s?1; Tape, 1.26 m·s?1, p < 0.05). The Froude efficiency was not affected (Normal, 0.77; Tape, 0.76), and ankle plantar angle did not decrease during swimming (Normal, 159.02°; Tape, 160.38°). In Experiment 2, lower limb rotations of a male swimmer were analysed using 3D motion analysis under the same conditions as Experiment 1. An insufficient forefoot rotation was observed during downstroke kicks (the phase of the highest acceleration to forward direction). These findings suggest that UUS velocity is affected by the mobility of end effector. 相似文献
5.
Yusuke Ikeda Hiroshi Ichikawa Rio Nara Yasuhiro Baba Yoshimitsu Shimoyama 《Journal of sports sciences》2017,35(2):189-195
The purpose of this study was to determine the installation of the backstroke start device reduces 15-m time. Thirteen college swimmers participated in this study. The aerial start and underwater motions were recorded with two digital video cameras. The center of mass (CM) of the swimmer, angular displacements and velocities of the shoulder, hip and knee joints were calculated. As an indicator of performance, the 5- and 15-m times were measured. The 5- and 15-m times in the backstroke start device condition were significantly shorter than in the non-backstroke start device condition. The vertical velocities of the CM at hand-off and toe-off in the backstroke start device condition were significantly greater than in the non-backstroke start device condition, while there was no significant difference in the CM horizontal velocity at toe-off. As a result, the height of the great trochanter at entry of the fingertips, with the backstroke start device, was 15 cm higher than in the non-backstroke start device condition. In addition, the CM horizontal velocities at 5 m in the backstroke start device condition were significantly greater than those of the non-backstroke start device. Thus, the use of the backstroke start device may reduce the 15-m time by diminution of the entry area. 相似文献
6.
Yoshihiro Okamoto Mayuri Tanaka Asami Kasahara Takazumi Hara Yoshimitsu Gotoh Naoya Fujita Takashi Fukui Toshiyuki Masuzawa 《Indian journal of clinical biochemistry : IJCB》2012,27(4):400-404
Most cytokine receptors including interleukin (IL)-9 have soluble counterparts in body fluids. We planned to investigate the pathophysiological significance of the serum soluble IL-9 receptor (sIL-9R) level. We determined the serum sIL-9Rα chain (sIL-9Rα) levels in 96 healthy Japanese individuals to establish a control value by means of specific human sIL-9Rα ELISA, followed by a preliminary application in a patient with diarrhea positive hemolytic uremic syndrome. Age was negatively correlated with the sIL-9Rα level (Spearman r = −0.241, n = 96, p = 0.0180). The serum sIL-9Rα level showed a progressive decline to the normal adult level by the age of 30. The serum sIL-9Rα level of the patient with HUS was markedly higher than those of the age-matched control from the onset of the disease. Because of the remarkable age-dependent variability of sIL-9Rα in healthy subjects, disease-related changes, as well as therapy-dependent alterations, should be considered with caution. Thus, it is recommended that when the serum sIL-9Rα levels of patients are evaluated, the values should be compared with those of age-matched controls. The established control value will be used to discriminate between normal and the pathological conditions in our future studies. 相似文献
1