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Guilherme Giannini Artioli Craig Sale Rebecca Louise Jones 《European Journal of Sport Science》2019,19(1):30-39
AbstractCarnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of research examining the ergogenic effects (or otherwise) of carnosine. More recent research, however, points towards a potential for carnosine to exert a wider range of physiological effects in other tissues, including the brain, heart, pancreas, kidney and cancer cells. Taken together, this is suggestive of a potential for carnosine to have therapeutic benefits in health and disease, although this is by no means without complication. Herein, we will provide a review of the current literature relating to the potential therapeutic effects of carnosine in health and disease. 相似文献
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Bruna C. Turi-Lynch Henrique Luiz Monteiro Rômulo Araújo Fernandes Xuemei Sui Ítalo Ribeiro Lemes Jamile Sanches Codogno 《Journal of sports sciences》2019,37(13):1443-1448
Objective: To analyze the possible dose-response association between components of sports participation (intensity, volume and previous engagement) and 4-year mortality rates among Brazilian adults.
Methods: 679 males and females (mean age among men = 66.7 ± 9.3 years old and mean age among women = 64.8 ± 8.9 years old) composed the study sample. Sports participation was assessed using Baecke’s questionnaire, which considers intensity, duration and previous engagement. Medical records were used to identify the cause of the death. Cox regression analysis was performed to determine the independent associations of exercise components and mortality.
Results: Participants that reported exercising at moderate-vigorous intensity (Moderate/vigorous: 4.1% versus None/light: 10.3% [p-value = 0.012]; HR = 0.42 [0.1 to 0.94)] and for more than four months (≥4 months: 5.3% versus <4 months: 10.2% [p-value = 0.038]; HR = 0.47 [0.24 to 0.94]) had lower mortality risk. The percentage of survival according to all-cause mortality was significantly higher for participants engaged in sports at moderate-vigorous intensity (p-value = 0.014), as well as for those engaged in sports for periods superior than four months (p-value = 0.036).
Conclusion: We found higher percentage of survival among adults engaged in sports at moderate-vigorous intensity and with at least four months of previous engagement. 相似文献
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Guilherme Nothen 《国际体育史杂志》2016,33(1-2):203-216
AbstractThe making of the 2007 Pan-American Games, held in the city of Rio de Janeiro, marked the beginning of the long transformation that this city would undergo in connection to sports mega-events. This paper revisits how the 2007 Pan-American Games were largely produced under the promise that its legacies, particularly the infrastructural ones, could be effectively mobilized in order to strengthen the chances of bringing the Olympics to Brazil for the first time. Whereas this rhetoric has proven somewhat successful in helping the city to secure the right to host the 2016 Olympics, the alleged connection between both events has shown to be much more limited than its proponents had initially advertized. In reality, most of the venues constructed for the Pan-American Games had to be thoroughly renovated for the Olympics, while some of them presented structural problems and/or failed to meet the standards imposed by international sports federations. 相似文献
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This essay considers gender in relation toBrazilian science and technology. It reviewsleading studies in the field, and offers briefbiographies of pioneering women in science.While there is still much room for improvement,the essay suggests that the situation of womenin science experienced significant progressduring the closing decades of the twentiethcentury. 相似文献
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Yixin Hu Aili Chen Xinchang Zheng Jun Lu Hailong He Jin Yang Ya Zhang Pinpin Sui Jingyi Yang Fuhong He Yi Wang Peifang Xiao Xin Liu Yinmei Zhou Deqing Pei Cheng Cheng Raul C Ribeiro Shaoyan Hu Qian-fei Wang 《国家科学评论(英文版)》2019,6(3):469
Standard chemotherapy regimens for remission induction of pediatric acute myeloid leukemia (AML) are associated with significant morbidity and mortality. We performed a cohort study to determine the impact of reducing the intensity of remission induction chemotherapy on the outcomes of selected children with AML treated with a low-dose induction regimen plus granulocyte colony stimulating factor (G-CSF) (low-dose chemotherapy (LDC)/G-CSF). Complete response (CR) after two induction courses was attained in 87.0% (40/46) of patients receiving LDC/G-CSF. Post-remission therapy was offered to all patients, and included standard consolidation and/or stem cell transplantation. During the study period, an additional 94 consecutive children with AML treated with standard chemotherapy (SDC) for induction (80/94 (85.1%) of the patients attained CR after induction II, P = 0.953) and post-remission. In this non-randomized study, there were no significant differences in 4-year event-free (67.4 vs. 70.7%; P = 0.99) and overall (70.3 vs. 74.6%, P = 0.69) survival in the LDC/G-CSF and SDC cohorts, respectively. After the first course of induction, recovery of white blood cell (WBC) and platelet counts were significantly faster in patients receiving LDC/G-CSF than in those receiving SDC (11.5 vs. 18.5 d for WBCs (P < 0.001); 15.5 vs. 22.0 d for platelets (P < 0.001)). To examine the quality of molecular response, targeted deep sequencing was performed. Of 137 mutations detected at diagnosis in 20 children who attained hematological CR after two courses of LDC/G-CSF (n = 9) or SDC (n = 11), all of the mutations were below the reference value (variant allelic frequency <2.5%) after two courses, irrespective of the treatment group. In conclusion, children with AML receiving LDC/G-CSF appear to have similar outcomes and mutation clearance levels, but significantly lower toxicity than those receiving SDC. Thus, LDC/G-CSF should be further evaluated as an effective alternative to remission induction in pediatric AML. 相似文献
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Luiz Guilherme Burlamaqui 《Soccer & Society》2019,20(7-8):1056-1070
ABSTRACTIn 1974, the Brazilian sports official João Havelange was elected FIFA’s president in a two-round election, defeating the incumbent Stanley Rous. The upset, often attributed to a successful alliance with Asia, the Middle East and Africa, what at the time was referred to as the Third World – surprised observers everywhere. Here, the election can be analysed as a historically relevant event of social significance. It can be thought of as a political window by means of which the international dynamic of a specific moment in the Cold War can be perceived, especially the limitations and potentialities of the agency available to periphery countries at that time. In this article, I intend to discuss the narratives that forged the history of FIFA, which take this political ‘event’ as a key in the institution’s own historical transformation. The sources analysed will be mainly FIFA official histories, such as the FIFA News, FIFA historical books and movies about the history of FIFA. 相似文献
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Mariana Rodrigues Rita Queiroga Ana Bela Ribeiro Natália Alves Tiago Neves 《International Journal of Lifelong Education》2020,39(1):61-74
ABSTRACT Precarious jobs and unemployment have become common issues for many young adults due to the unfavourable labour market situation in Portugal. Against this background, lifelong learning (LLL) policies have been called in to play a role in creating economic growth and supporting the social inclusion of young adults in vulnerable educational and economic circumstances. These policies are defined at the national level; however, their implementation depends on the action of local actors who face specific challenges. This paper explores disparities in the definition and implementation of LLL policies targeting young adults in two Portuguese regions. Specifically, we analyse professional courses in Vale do Ave (North) and adult education and training courses in Alentejo Litoral (South). These regions were selected due to their dissimilar economic structure. This study adopted a qualitative approach through interviews with LLL experts and policy roundtables with local stakeholders and decision-makers in both regions. Data were transcribed and analysed using NVivo 10. The study shows that the two regions have different cooperation networks between local stakeholders, and that these impact the opportunities to influence the regional skills formation system differently. Also, the study shows that LLL policies are not designed to address destandardised life courses. 相似文献
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