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The aims of this study were to examine the changes in plasma concentrations of inflammatory cytokines induced by training and competition in professional cyclists. We report the serum concentrations of interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-a), tumour necrosis factor receptors I and II (TNFR-I and -II) in a prospective, randomized, double-blind trial involving the administration of AM3 (Inmunoferon), an oral booster immunomodulator, or placebo to 16 professional cyclists (n = 8 in each group) for 65 consecutive days. Serum was collected just before treatment began (baseline), at the end of pre-competition training, before the mountain stage of the competition (60 days), 4 h after finishing this stage (62 days), and 18 h after the fifth and last day of competition (65 days). To determine the normal levels of cytokines and soluble TNF receptors, individual samples from 14 moderately trained healthy controls were studied. After 60 days of training, the serum concentrations of IL-6 did not differ significantly from those at the beginning of the study for either group of cyclists (placebo and AM3). A significant rise was seen in IL-6 concentrations in both the AM3 and placebo groups at 62 days, 4 h after finishing the mountain stage. The increase was significantly greater in the placebo group than in the AM3 group. At 65 days of treatment, 18 h after the fifth and last day of competition, IL-6 concentrations were similar to those recorded at the end of the training, but were significantly higher in the placebo group than in the AM3 group. At the end of training, serum TNFR-I concentrations in both groups of cyclists were significantly lower than at baseline. The concentrations of serum TNFR-I and -II both 4 h after finishing the mountain stage and 18 h after the fifth and last day of competition were significantly higher than those recorded after training in both groups. Professional cycling competition is associated with increases in serum IL-6 and TNFR-I and -II concentrations. Inmunoferon treatment reduced significantly the concentrations of IL-6 but not those of TNFR-I and -II. 相似文献
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Rodolfo herrero Ricaño Héctor Barrón Soto 《The American journal of distance education》2013,27(1):68-71
Abstract Since 1947, distance education in Mexico has had an important role for nonconventional populations. Considering that distance education is a heterogeneous and dynamic field, it is important to reflect on the need to improve quality as measured by our own standards. With that perspective in mind, a national meeting was organized to start a self‐diagnosis in which quality and access were the main concerns. Five hundred and twenty specialists from fifty‐one institutions participated in a national interactive synchronous meeting held in four regions. As a result of the meeting, thirty‐five criteria and 230 parameters of quality were established. The main conclusion of the meeting refers to the need for the elaboration of our own indicators for open and distance education. 相似文献
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In this study, we compared hamstring (H) and quadriceps (Q) strength changes in men and women, as well as changes in conventional and functional H:Q ratios following an identical 12-week resistance training program. An isokinetic dynamometer was used to assess 14 male and 14 female participants before and after the intervention, and conventional and functional H:Q ratios were calculated. Hamstring strength improved similarly in men and women, but improvement in quadriceps strength was significantly greater in men, while women showed only modest improvements. For the conventional and functional H:Q ratios, women showed significantly greater improvements than men. Both men and women were able to exceed the commonly recommended 0.6 conventional and 1.0 functional H:Q ratios after the 12-week lower-body resistance training program. 相似文献
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Mary Esther Soto Huerta 《Journal of Latinos & Education》2017,16(3):192-202
This study contributes to the limited research on emergent bilinguals, perspective taking, and second language reading of informative text. The explicit integration of Freire’s (1993) notion of conscientizacao, or consciousness-raising, with the constructs of empathy and embodiment (Gee, 2001; Hurtado, 1996) and with translanguaging (García, 2009) represented conceptual frameworks that explicitly guided the pedagogical approaches implemented in the study. The findings indicated that the incorporation of the integrated conceptual frameworks with the prescribed fourth grade social studies curriculum enabled emergent bilinguals to generate their own perspectives concerning social justice and equity when studying about slavery in Texas. 相似文献
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Tae Kyoung Lee Alan Meca Jennifer B. Unger Byron L. Zamboanga Lourdes Baezconde-Garbanati Melinda Gonzales-Backen Elma I. Lorenzo-Blanco Miguel Á. Cano Sabrina E. Des Rosiers Daniel W. Soto Juan A. Villamar Monica Pattarroyo Karina M. Lizzi José Szapocznik Seth J. Schwartz 《Child development》2020,91(1):78-95
Acculturation consists of multiple domains (i.e., cultural practices, identifications, and values). However, less is known about how acculturation processes influence each other across multiple domains of acculturation. This study was designed to investigate transition patterns of acculturative processes within and across domains in a sample of 302 recent-immigrant Hispanic adolescents, Mage (SD) = 14.51 years (0.88) at baseline; male = 53%). Adolescents were assessed six times over a 3-year period. Latent profile analyses identified two profiles (high [or increasing] vs. low) for each domain at each timepoint. We found largely stable transition patterns in each domain over six timepoints. Importantly, sequential associations among profiles in acculturation domains were also detected. Implication for acculturation theory and research are discussed. 相似文献
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Rainer Simon Elton Barker Leif Isaksen Pau De Soto CaÑamares 《Journal of Map & Geography Libraries》2017,13(1):111-132
Recogito 2 is an open source annotation tool currently under development by Pelagios, an international initiative aimed at facilitating better linkages between online resources documenting the past. With Recogito 2, we aim to provide an environment for efficient semantic annotation—i.e., the task of enriching content with references to controlled vocabularies—in order to facilitate links between online data. At the same time, we address a perceived gap in the performance of existing tools, by emphasizing the development of mechanisms for manual intervention and editorial control that support the curation of quality data. While Recogito 2 provides an online workspace for general-purpose document annotation, it is particularly well-suited for geo-annotation, in other words annotating documents with references to gazetteers, and supports the annotation of both texts and images (i.e., digitized maps). Already available for testing at http://recogito.pelagios.org, its formal release to the public occurred in December 2016. 相似文献
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Encarnación Soto Gómez María José Serván Núñez Noemí Peña Trapero Ángel Ignacio Pérez Gómez 《Educational Action Research》2019,27(4):527-542
ABSTRACTThis article aims to set out our discussions, reflections and research at Málaga University (Spain) in relation to Lesson Study (LS), as a cooperative action research process. The paper aims to summarise the main findings of ten years of research, addressing the concepts and dilemmas found both in forming teachers’ practical thinking and in the complex processes of reconstruction through LS. The results of our research provide evidence that it is a useful way to deal with the reconstruction of teachers’ practical knowledge in teacher training. Teachers’ practical knowledge should be more broadly seen as an active combination of theoretical knowledge, procedural knowledge and skills, attitudes, emotions, believes, and values: i.e. teachers’ practical thinking. Most of these personal and professional resources are unconscious, or rather sub-conscious. Changes in teachers’ practical thinking require more practical experience and reflexion: a dialectical process based around two key components: theorisation of practice and experimentation of reconstructed theory. The results of our research show that these dialectical process could be developed with LS as a particular way of developing AR, adding a complex, systematic, flexible and cooperative way of dealing with specific and contextual curricular innovation projects. We therefore conclude that LS could be a very useful path to follow in reconstructing teachers’ practical thinking from within, strengthening the professional teaching community. 相似文献
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Erin L. Meyer Barbara A. Schaefer Cesar Merino Soto Crystal S. Simmons Rebecca Anguiano Jeremy Brett Alea Holman Justin F. Martin Heidi K. Hata Kimberly J. Roberts Zena R. Mello Frank C. Worrell 《Psychology in the schools》2011,48(10):931-942
Behavior rating scales aid in the identification of problem behaviors, as well as the development of interventions to reduce such behavior. Although scores on many behavior rating scales have been validated in the United States, there have been few such studies in other cultural contexts. In this study, the structural validity of scores on a Spanish translation of the six‐factor Child Behavior Scale (CBS) was assessed in a sample of 265 Peruvian preschool children who ranged from 2 to 6 years in age. Exploratory factor analysis yielded a four‐factor structure, and reliability estimates for scores on the four factors were adequate. The authors suggest replicating the study and examining the utility of CBS scores in predicting future problem behaviors in this population. © 2011 Wiley Periodicals, Inc. 相似文献