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Sudhir Kurl Sae Young Jae Timo H.Makikallio Ari Voutilainen Magnus J.Hagnas Jussi Kauhanen Jari A.Laukkanen 《运动与健康科学(英文)》2022,11(2):266-271
Background:Little is known about exercise cardiac power(ECP),defined as the ratio of directly measured maximal oxygen uptake with peak systolic blood pressure during exercise,on heart failure(HF)risk.We examined the association of ECP and the risk of HF.Methods:This was a population-based cohort study of 2351 men from eastern Finland.The average time to follow-up was 25 years.Participants participated at baseline in an exercise stress test.A total of 313 cases of HF occurred.Results:Men with low ECP(<9.84 mL/mmHg,the lowest quartile)had a 2.37-fold(95%confidence interval(95%CI):1.68-3.35,p<0.0001)hazards ratio of HF as compared with men with high ECP(>13.92 mL/mmHg,the highest quartile),after adjusting for age.Low ECP was associated with a 1.96-fold risk(95%CI:1.38-2.78,p<0.001)of HF after additional adjustment for conventional risk factors.After further adjustment for left ventricular hypertrophy,the results hardly changed(hazards ratio=1.87,95%CI:1.31-2.66,p<0.001).One SD increase in ECP(3.16 mL/mmHg)was associated with a decreased risk of HF by 28%(95%CI:17%-37%).Conclusion:ECP provides a noninvasive and easily available measure from cardiopulmonary exercise tests in predicting HF.However,ECP did not provide additional value over maximal oxygen uptake. 相似文献
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Sudhir R. Ghorpade 《Resonance》2013,18(5):397-411
Shreeram Shankar Abhyankar, an extraordinary mathematician and educator, passed away on November 2, 2012 at the age of 82. He remained active in research as well as teaching and was constantly engaged in “doing mathematics” almost till his last breath. This, and the accompanying articles, are meant as a tribute to Prof. Abhyankar and an attempt to provide some glimpses of the person and his work. 相似文献
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Colloids play an important role in our modern lives. In this article, we briefly discuss various forces that are known to operate between colloidal particles and then take the reader through the discovery of a new, strong and long ranged force operating between hydrophobic particles/surfaces. Characteristics of the new force and some promising theories proposed in the literature to explain its origin are also discussed; the origin of the new force is not yet resolved, however. 相似文献
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Sudhir R. Jain 《Resonance》2014,19(9):797-813
The idea of adiabatic invariance is presented in the context of simple classical mechanical models. The adiabatic invariant jumps across the separatrix — an attempt has been made to bring out the basic ideas underlying the Melnikov-Arnold integral. This becomes important as soon as a perturbation to a regular, stable system makes it dynamically unstable. 相似文献
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K. Sudhir 《Publishing Research Quarterly》2010,26(4):255-265
With the rapid growth in the Chinese and Indian economies, the opportunities for publishers have dramatically expanded. The
paper discusses the regulatory, political, economic and cultural factors to be considered in entering these markets. Finally,
the paper discusses three key tradeoffs to be considered in these markets: standardization/localization, volume/margin and
the relative importance of digital/paper publications. 相似文献
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Renu Yadav Babban Jee Sudhir Kumar Awasthi 《Indian journal of clinical biochemistry : IJCB》2015,30(1):109-112
Curcumin is a major bioactive compound of turmeric that exerts its anti-inflammatory effects by suppressing the many pro-inflammatory cytokines and chemokines in a number of cell types and pathologic conditions. Interleukin-18 (IL-18) is a novel pro-inflammatory cytokine which plays an important role not only in generating Th1 responses but also in inducing severe inflammatory reactions. As curcumin induced inhibition of IL-18 production in keratinocytes and mice is well known, effect of curcumin on IL-18 release in macrophages remains unknown. Hence, this present study has been designed to evaluate the effect of curcumin on IL-18 production and necrotic cell death in murine macrophages-like cells treated with or without lipopolysaccharide (LPS). The IL-18 secretion in cell culture supernatants was assayed by enzyme-linked immunosorbent assay and cytotoxicity was determined by lactate dehydrogenase release assay. Our results demonstrate that curcumin significantly inhibited the production of pro-inflammatory cytokine IL-18 in E.coli LPS stimulated murine macrophage-like cells RAW264.7 in a concentration-dependent manner. Interestingly, curcumin had no cytotoxic effect on murine macrophage-like cells. Our findings suggest that curcumin may be used as a potential therapeutic agent for the treatment of inflammatory diseases. 相似文献
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In an article in the July 1995 issue of Educational Studies in Mathematics, Even and Tirosh claim that the quantity (-8)1/3 is undefined. We present arguments to show why the reasoning given by them is flawed.This revised version was published online in September 2005 with corrections to the Cover Date. 相似文献
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Pushpa Durgawale Sudhir Kanase Pramod S. Shukla Shubhangi Sontakke 《Indian journal of clinical biochemistry : IJCB》2005,20(2):174-177
Cerebrospinal fluid protein estimation is a routine diagnostic tool for various diseases. The proposed modified bromocresol
green (BCG) method is applicable to automated as well as manual measurements. Protein concentrations and absorbance at 600
nm are linearly related throughout a wide range of concentrations from 10 mg % to 2000 mg %. Ninety C.S.F. samples were analyzed
and results obtained by both the modified BCG method and routine pyrogallol red method were compared. An excellent co-relation
was observed (n=90, g=0.996, P<0.001). 相似文献
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