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1.
Reema George Harikrishnan Sivadasanpillai Narayani Jayakumari Anugya Bhatt Jissa V. Thulaseedharan Jaganmohan A. Tharakan 《Indian journal of clinical biochemistry : IJCB》2016,31(3):302-309
Thrombotic risk factors may contribute to premature coronary artery disease (CAD), in addition to the conventional risk factors. There is paucity of data on studies evaluating the role of thrombotic factors in premature CAD in Indian patients. Thus a case–control study was performed to evaluate the role of thrombotic and atherogenic factors in young patients with angiographically proven CAD who are on treatment with statins and anti-platelet drugs. 152 patients (≤55 years) with angiographically proven CAD and 102 asymptomatic controls were recruited. Clinical and biochemical data were obtained in both groups. Blood levels of thrombotic factors-fibrinogen, antithrombin-III, tissue-plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), von-Willebrand factor (v-WF), lipoprotein(a) [Lp(a)] and homocysteine were analyzed. Patients had high levels of conventional CAD risk factors (diabetes mellitus, smoking, hypertension, dyslipidemia and positive family history) compared to controls. Logistic regression analysis revealed that low antithrombin-III (odds ratio/OR 11.2; 95 % confidence interval/CI 2.29–54.01), high fibrinogen (OR 6.04; 95 % CI 1.09–33.21) and high Lp(a) (OR 4.54; 95 % CI 0.92–22.56), as important, independent risk factors in patients. PAI-1(OR 0.15; 95 % CI 0.03–0.69) levels were significantly lower in patients. But other thrombotic risk factors studied (t-PA, v-WF and homocysteine) were comparable among patients and controls. The treatment using statins and anti-platelet drugs might be contributing to the control of some of the thrombotic risk factors. The strategies aiming at lowering the levels of thrombotic risk factors along with conventional risk factors may be useful in primary and secondary prevention of CAD. 相似文献
2.
Kavita Shalia Sudha Savant Vijaya A. Haldankar Tulip Nandu Poonam Pawar Siddhi Divekar V. K. Shah Purvi Bhatt 《Indian journal of clinical biochemistry : IJCB》2012,27(1):74-82
To analyse the association of high sensitivity C-reactive (hsCRP) protein levels and −717A/G single nucleotide polymorphism
of CRP with acute myocardial infarction (AMI) in the Indian population. Study population included 100 MI cases wherein 32
patients had experienced previous MI (MI-Group-1), 68 MI cases were recruited at presentation (MI-Group-2) and equal number
of age and gender matched healthy individuals. hsCRP levels were determined by ELISA and genotyping of −717A/G was carried
out by polymerase chain reaction-based restriction digestion method. The −717A/G genotypes did not influence hsCRP level and
their distribution did not differ between groups. However, in the present study hsCRP demonstrated significant correlation
with BMI in controls of both the genders and with triglycerides in females of AMI at presentation who otherwise are with low
risk profile. Identifying traditional risk factors associated with inflammation may help in controlling the acute event. 相似文献
3.
H. R. Mali S. A. Siddiqui Madhur Garg R. K. Singh M. L. B. Bhatt 《Indian journal of clinical biochemistry : IJCB》1998,13(1):36-40
Present study repots changes in serum copper levels (SCL) in various neoplastic diseases undergoing radiotherapy. We estimated
SCLs in 140 individuals comprising of 90 previously untreated patients with various malignancies and 50 healthy controls.
Patients received radiation in doses of 40–70 Gy in 4–7 weeks. SCLs were again estimated in patients following irradiation.
The mean SCL was significantly higher (P<0.001) in cancer patients as compared to healthy controls. It declined significantly
(P<0.001) following irradiation. However, it remained significantly higher as compared to healthy controls (P<0.01). Highest
fall in SCL was seen in complete clinical responders and least in non-responders to radiation treatment. Serial estimation
of SCLs may be useful in the treatment monitoring of the neoplasms undergoing radiation treatment. 相似文献
4.
M. V. Bhatt 《Resonance》1998,3(4):88-93
Several interesting historical details about the structure of benzene and the concept of aromaticity are provided. 相似文献
5.
Infants as young as 3 months of age can encode the relations among object features. Because object recognition depends critically upon a match between perceived feature configurations and representations of the object in long-term memory, the present experiments focused on infants' long-term memory for feature correlations. In 3 experiments with 72 3-month-olds, we documented the forgetting functions of different feature correlations, examined their relation to infants' memory for individual features, and replicated the findings with different stimuli. Infants were trained to activate a mobile composed of two kinds of blocks that differed in color, the figures displayed on them, and the figures' colors and were tested after different delays with recombinations of either the block colors, the figures, or the figure colors. Infants remembered some of the original feature combinations for up to 3 days but forgot all of them after 4 days. Even after 4 days, however, infants remembered the individual features that had entered into the original combinations. These results demonstrate that very young infants not only encode the relations among object features but also remember them for several days. Moreover, there is a dissociation in memory between features and feature relations: Feature relations are forgotten sooner than the individual features that comprise those relations. 相似文献
6.
Pramod Chandra P Bhatt 《Resonance》2014,19(6):549-569
Lately there has been a lot of excitement about disruptive forms of ‘money’ — cryptocurrencies. This article traces the evolution of cryptocurrencies focusing on the enabling technologies and some theoretical foundations. We shall also explore the challenges they pose to well-established monetary systems. 相似文献
7.
H. R. Mali M. L. B. Bhatt M. P. Singh S. M. Natu J. P. Gupta 《Indian journal of clinical biochemistry : IJCB》1996,11(1):56-58
Serum sialic acid levels were determined in 66 patients of carcinoma cervix and 25 control women matched for age. Mean sialic acid level was significantly elevated (p<0.001) in cancer cervix patients as compared to controls. Patients were treated with 50–65 Gy of radiation in 5–6.5 weeks. Post-therapy levels were again determined. Radiotherapy caused decline in serum sialic acid level in all the patients except one. Mean post-therapy level was significantly lower as compared to pretreatment level (p<0.001). It was also observed that fall in sialic acid level was significantly higher (p<0.05) in early stage patients as compared to late stage. No relationship was observed in the dose of radiation and fall in serum sialic acid level. A significantly higher fall in serum sialic acid level was observed in patients having complete clinical response as compared to partial or nonresponders to radiation treatment (p<0.001). 相似文献
8.
Adults use both first-order, or categorical, relations among features (e.g., the nose is above the mouth), and second-order, or fine spatial relations (e.g., the space between eyes), to process faces. Adults' expertise in face processing is thought to be based on the use of second-order relations. In the current study, 5-month-olds detected second-order changes, but 3-month-olds failed to detect second-order changes induced by 2 different manipulations. Three-month-olds did detect first-order changes, however. Also, inversion affected 5-month-olds' processing of second-order but not first-order information. These results suggest that, although sensitivity to first-order relations is available by 3 months or earlier, sensitivity to second-order information may not develop until sometime between 3 and 5 months of age. 相似文献
9.
The Academic Database Assessment Tool (ADAT) from the Joint Information Systems Committee (JISC) enables users to compile and compare journal title lists from many different suppliers. The makers claim that this tool can help identify overlap of coverage among comparable databases and platforms. This article provides an overview of the tool's major features, including limitations, and how it can be used in academic libraries to make informed collection development and management decisions regarding electronic databases. 相似文献
10.
Pramod Chandra P. Bhatt 《Resonance》2012,17(8):727-747
UNIX was primarily designed by Ken Thompson and Dennis Ritchie at Bell Labs. It was, and continues to be, regarded as a seminal contribution to operating systems design methodology, architecture and research. The primary strengths of UNIX lie in the soundness of underlying design principles. This article aims at providing insights into the making of UNIX and in particular, how the notion of open software helped in taking a utility- and tool-driven approach. This approach provides both usability1 and extensibility besides maintainability. In fact, we see that the designers used best software architecture practices. We discuss UNIX shell and its operating environment, kernel, file systems, process creation and management, version management and documentation standard. Every effort has been made to quote from authentic sources to trace history. 相似文献