Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Social‐Information‐Processing Skills of Kindergarten Children with Developmental Learning Disabilities     

Hana Tur‐Kaspa 《Learning disabilities research & practice》2004,19(1):3-11

The study examined the social‐information‐processing skills of kindergarten children with developmental learning disabilities (LD) utilizing Crick and Dodge's (1994) model of children's social adjustment as a theoretical framework. Participants consisted of 20 kindergarten children with developmental LD who attended three integrated kindergartens and 20 children without developmental LD from the same kindergartens. Participants were assessed on social‐information‐processing skills, feelings of loneliness, sense of coherence, and teachers' ratings of behavioral problems and positive resources. The results indicated that girls with developmental LD performed significantly lower on two information‐processing steps—the response decision and the enactment steps—than did girls without LD. Such differences were not found for boys. The results also showed that the social‐information‐processing skills of children with developmental LD were correlated with teachers' ratings.  相似文献   

On Shifting Ground: the post‐paradigm identity of US comparative education, 1979‐88 [1]     

Heidi Ross  Cho‐Yee To  William Cave  David E. Bair 《Compare》1992,22(2):113-131

  相似文献   

Mental State Verb Production in the Oral Narratives of English‐ and Spanish‐Speaking Preadolescents: An Exploratory Study of Lexical Diversity and Depth     

Belinda Fust‐Herrmann  Elaine R. Silliman  Ruth H. Bahr  Kyna S. Fasnacht  Jeanne E. Federico 《Learning disabilities research & practice》2006,21(1):44-60

  相似文献   

Review article     

Athina Kolia‐Dermitzaki 《Al-Masaq: Islam & the Medieval Mediterranean》1994,7(1):267-278

Ducellier, A., Kaplan, M., Martin, Bernadette, avec la collaboration de Françoise Micheau. Le Moyen Âge en Orient. Byzance et l'Islam. Des Barbares aux Ottomans. Paris: Hachette Histoire Université, 1990.  相似文献   

European perspectives on men and masculinities,by Jeff Hearn and Keith Pringle with members of CROME (Critical Research on Men in Europe)     

Anna C. Hickey‐Moody 《Gender and education》2009,21(2):235-236

  相似文献   

Benchmarking scientific journals from the submitting author's viewpoint     

Bo‐Christer Bjrk  Jonas Holmstrm 《Learned Publishing》2006,19(2):147-155

  相似文献   

Health science libraries in Sweden: new directions,expanding roles          下载免费PDF全文

Lotta Haglund  Annikki Roos  Petra Wallgren‐Björk 《Health information and libraries journal》2018,35(3):251-255

Librarians in Sweden are facing huge challenges in meeting the demands of their organisations and users. This article looks at four key areas: coping with open science/open access initiatives; increasing demands from researchers for support doing systematic reviews; understanding user experiences in Swedish health science libraries; and the consequences of expanding roles for recruitment and continuing professional development. With regard to changing roles, there is an increasing shift from the generalist towards the expert role. The authors raise the issue as to how to prepare those new to the profession to the changing environment of health science libraries.  相似文献   

American Women's Wartime Dress: Sociocultural Ambiguity Regarding Women's Roles During World War II          下载免费PDF全文

Martha L. Hall  Belinda T. Orzada  Dilia Lopez‐Gydosh 《Journal of American culture (Malden, Mass. : 2003)》2015,38(3):232-242

  相似文献   

My Aspergirl: Stieg Larsson's Millennium Trilogy and Visualizations     

Sheng‐mei Ma 《Journal of American culture (Malden, Mass. : 2003)》2014,37(1):52-63

  相似文献