Advantages and Limitations of Open Source Software for Library Management System Functions: The Experience of Libraries in India     

Ojaswini Subodh Upasani 《期刊图书馆员》2016,71(2):121-130

The explosion of availability of information on the Internet requires that libraries evolve into value-added information providers, rather than mere curators of collections. Modern libraries need to stay relevant to a diverse, technologically savvy patron base and to facilitate and add value to the research community, while facing significant resource constraints. To face these challenges, libraries need to embrace digital technologies and library management systems (LMS) in order to work smart and achieve more with less. While LMS systems have been around for decades, libraries can explore the new frontier by embracing open source solutions, like open source software (OSS) library systems, which are free to acquire. They need to collaborate with computer experts and become technologically savvy to harness the full power of OSS solutions to meet the specific needs of the library and patron base. This article provides an overview of the availability, benefits, and drawbacks of various LMS systems and OSS variants, drawing from experiences in the present Indian context.  相似文献   

Circulating Biomarkers and their Possible Role in Pathogenesis of Chronic Hepatitis B and C Viral Infections     

Khan S  Bhargava A  Pathak N  Maudar KK  Varshney S  Mishra PK 《Indian journal of clinical biochemistry : IJCB》2011,26(2):161-168

The present study evaluated the plausible role of circulating biomarkers in immune pathogenesis of chronic hepatitis considered a priority in clinical hepatology. Total viral load of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) patients was quantified and correlation studies were performed with circulating levels of Th1/Th2 cytokines; C reactive protein and circulating nucleosomes; glutathione reductase (GR) and superoxide dismutase. To our knowledge, the study is first among its kind that validates strong positive correlation of viral load with IL-4, IL-6, GR in HBV and IL-6, IL-10, GR in HCV infections. Although, multi-centric studies including large cohorts are required for translating our findings to clinical practice, however, role of these biomarkers with potential diagnostic or prognostic significance might be helpful in clinical assessment of high-risk individuals, thereby, designing interventional strategies, towards development of personalized medicare. The results of our study also offer valuable insights of immune signaling mediators engaged in development of hepatocellular carcinoma.  相似文献   

Impairment of Mitochondrial–Nuclear Cross Talk in Neutrophils of Patients with Type 2 Diabetes Mellitus     

Saba Khan  Gorantla V. Raghuram  Neelam Pathak  Subodh K. Jain  Dolly H. Chandra  Pradyumna K. Mishra 《Indian journal of clinical biochemistry : IJCB》2014,29(1):38-44

Increased leukocyte apoptosis is intrinsically linked to disease patho-physiology, susceptibility to and severity of infections in type 2 diabetes mellitus (T2DM) patients. A consistent defect in neutrophil function is considered central to this increased risk for infections. Although redox imbalance is considered a potential mediator of these associated complications, detailed molecular evidence in clinical samples remains largely undetected. The study consisted of three groups (n = 50 each) of Asian Indians: early diagnosed diabetic patients, cases with late-onset diabetic complications and age and gender-matched healthy controls. We evaluated mitochondrial oxidative stress, levels of nuclear DNA damage and apoptosis in peripheral blood neutrophils isolated from T2DM patients. We observed that in both early and late diabetic subjects, the HbA1c levels in neutrophils were altered considerably with respect to healthy controls. Increased oxidative stress observed in both early and late diabetics imply the disentanglement of fine equilibrium of mitochondria-nuclear cross talk which eventually effected the augmentation of downstream nuclear γH2AX activation and caspase-3 expression. It would be overly naïve to refute the fact that mitochondrial deregulation in neutrophils perturbs immunological balance in type 2 diabetic conditions. By virtue of our data, we posit that maneuvering mitochondrial function might offer a prospective and viable method to modulate neutrophil function in T2DM. Nevertheless, similar investigations from other ethnic groups in conjunction with experimental evidences would be a preeminent need. Obviously, our study might aid to comprehend this complex interplay between mitochondrial dysfunction and neutrophil homeostasis in T2DM.  相似文献