Antioxidant Status and Oxidative Stress in the Circulation of Younger and Elderly Human Subjects     

P. Faizal  B. Satheeshan  Milindkumar  A.K. Adarsh  R. Shilpa  P. Roshni  T. Remya  K.T. Augusti 《Indian journal of clinical biochemistry : IJCB》2013,28(4):426-428

Extensive research has demonstrated the protective properties of antioxidants, which scavenge reactive oxygen species and their precursors, as well as up-regulate enzymes involved in the repair of cellular damage. Several case–control studies have showed higher blood levels of antioxidants and decreased oxidative stress in younger individuals when compared with older ones. Cell damage caused by free radicals appears to be a major contributor in aging and degenerative diseases of aging such as cancer, cardiovascular disease, cataracts, compromised immune system, rheumatoid arthritis and brain dysfunction. The objective of this study was to determine the variation of Circulating levels of selected antioxidants (enzymic and non enzymic) and oxidative stress marker in younger and older humans. The results showed that a majority of the younger age group participants showed a significant increase in enzymic and nonenzymic antioxidant status and a decrease in oxidative stress when compared with the older age group.  相似文献   

Quality of author guidelines of journals in the biomedical and physical sciences     

Remya NAMBIAR  Priyanka TILAK  Clarinda CEREJO 《Learned Publishing》2014,27(3):201-206

To assess quantitatively the completeness and clarity of author guidelines of international English‐language journals in the biomedical and physical sciences, we randomly sampled 80 journals for which author guidelines were available online in English. The guidelines were reviewed for completeness and clarity in addressing ‘aims and scope’, ‘submission and post‐submission processes’, ‘formatting instructions’, ‘ethical requirements’, and ‘authorship’, and were subjectively assessed as being complete (score 1) or incomplete (0), and clear (1) or unclear (0). Scores were represented as mean percentages. No journal scored 100% for completeness and clarity. ‘Formatting instructions’ was the most complete and clear category, and ‘authorship’ the least complete and clear category. Biomedical science journals were more complete and clear in all categories, except ‘authorship‘, compared to physical science journals. While author guidelines of many English‐language journals of biomedical and physical sciences adequately address some essential aspects, they currently do not provide all necessary information as clearly as possible.  相似文献