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BackgroundThe 6-minute walking distance (6MWD) is an excellent measure of both functional endurance and health. The primary aim of this study was to estimate temporal trends in 6MWD for older Japanese adults between 1998 and 2017; the secondary aim was to estimate concurrent trends in body size (i.e., height and mass) and self-reported participation in exercise/sport.MethodsAdults aged 65–79 years were included. Annual nationally representative 6MWD data (n = 103,505) for the entire period were obtained from the Japanese Ministry of Education, Culture, Sports, Science and Technology. Temporal trends in means (and relative frequencies) were estimated at the gender–age level by best-fitting sample-weighted linear/polynomial regression models, with national trends estimated by a post-stratified population-weighting procedure. Temporal trends in distributional variability were estimated as the ratio of coefficients of variation.ResultsBetween 1998 and 2017 there was a steady, moderate improvement in mean 6MWD (absolute = 45 m (95% confidence interval (95%CI): 43–47); percent = 8.0% (95%CI: 7.6%–8.4%); effect size = 0.51 (95%CI: 0.48–0.54)). Gender- and age-related temporal differences in means were negligible. Variability in 6MWD declined substantially (ratio of coefficients of variation = 0.89, 95%CI: 0.87–0.92), with declines larger for women compared to men, and for 75–79-year-olds compared to 65–74-year-olds. Correspondingly, there were moderate and negligible increases in mean height and mass, respectively, and negligible increases in the percentage who participated in exercise/sport at least 3 days per week and at least 30 min per session.ConclusionThere has been a steady, moderate improvement in mean 6MWD for older Japanese adults since 1998, which is suggestive of corresponding improvements in both functional endurance and health. The substantial decline in variability indicates that the temporal improvement in mean 6MWD was not uniform across the distribution. Trends in 6MWD are probably influenced by corresponding trends in body size and/or participation in exercise/sport.  相似文献   
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Arabic is a morphologically rich language that presents significant challenges to many natural language processing applications because a word often conveys complex meanings decomposable into several morphemes (i.e. prefix, stem, suffix). By segmenting words into morphemes, we could improve the performance of English/Arabic translation pair’s extraction from parallel texts. This paper describes two algorithms and their combination to automatically extract an English/Arabic bilingual dictionary from parallel texts that exist in the Internet archive after using an Arabic light stemmer as a preprocessing step. Before using the Arabic light stemmer, the total system precision and recall were 88.6% and 81.5% respectively, then the system precision an recall increased to 91.6% and 82.6% respectively after applying the Arabic light stemmer on the Arabic documents.  相似文献   
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Objective

The ideal medication for the treatment of acid-related diseases, e.g., peptic ulcers, stress-related gastric bleeding, functional dyspepsia, and gastroesophageal reflux disease, should have a rapid onset of action to promote hemostasis and relieve the symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor, omeprazole 20 mg, and an H2-receptor antagonist, roxatidine 75 mg.

Methods

Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg. Each administration was separated by a 7-d washout period.

Results

During the 6-h study period, the average pH after administration of roxatidine was higher than that after administration of omeprazole (median: 4.45 vs. 2.65; P=0.0367). Also during the 6-h study period, a longer duration of maintenance at pH above 2, 5, and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg (median: 90.6% vs. 55.2%, P=0.0284; 43.7% vs. 10.6%, P=0.0125; 40.3% vs. 3.3%, P=0.0125; respectively).

Conclusions

In Helicobacter pylori-negative healthy male subjects, oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg.  相似文献   
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ABSTRACT

The National Museum of Ethnology, Osaka, Japan, collects a vast amount of materials and information related to peoples’ life and culture, and makes them available to society through exhibitions and other activities. The number of collected items is increasing every year: 343581 objects have been collected from Japan and abroad as of March 2017. The continuous efforts have been necessary to improve storage conditions and to save space for both general and special storerooms. The former, which account for 90% of the storage capacity of the museum, are air-conditioned during working hours, with temperature and relative humidity (RH) settings varying with the seasons. The latter, which house objects for which strict conservation conditions are required, are air-conditioned for 24 hours with fixed settings of temperature/RH throughout the year determined by the nature of the materials from which the objects have been made or formed. Storage re-organization began with special storerooms, for which the number of objects and the storage area are far more limited in comparison with the general storerooms. The storage shelves for fur/skin/feather (almost 1000 objects) and for carpets (almost 550 objects) were all renewed in FY2007/2008. Then two large-scale innovation projects for general storerooms were conducted: construction of storage areas for ships equipped with a CO2-based and anoxic pest treatment facility (FY2015), and a complete refurbishing of the general storeroom for large objects (FY2016). Windows were set in the corner of this storeroom to provide visitors an opportunity to view and learn about the museum activities. In parallel to the above projects, daily storage improvement efforts have been undertaken. Storeroom No. 3, chosen as an example for general storerooms for small and medium-sized objects, was used to investigate the range of issues related to the shelving arrangement and storage conditions. Guidelines for storage re-organization were formulated according to the results of the investigation and according to the experiences gained through the renewal of special storerooms. Storage re-organization undertaken in storeroom No. 3 was conducted for 6 years at the rate of around 2000–4000 objects per year with a low budget and with reuse of existing shelves. In FY2016, all objects in storeroom No. 3 were properly redistributed. About 40% of the storage space was saved. Over these 10 years of storage re-organization, preventive measures have been taken for sustainable collection management. As early as FY1992, pest trap investigations have been carried out seasonally. Since FY2004, the results of investigations have been analyzed using a customized computer program. Subsequently, appropriate integrated pest management measures have been taken. In addition, since FY2014, energy-efficient air-condition control has been adopted for general storerooms. It consists of switching off air-conditioning in spring and autumn, and of starting it only when the temperature or RH values become too high in summer or too low in winter. Because the turning-off of air-conditioning causes comparable or even less climatic fluctuation, it was considered acceptable both economically and from a conservation perspective. It is estimated that turning the air-conditioning off during transitional seasons brings cost savings of about 3000000–4000000 JPY (about 26800–35700 USD as of 23 September 2017) per annum, which accounts for almost 30% of the electricity expenditures for all general storerooms.  相似文献   
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By using unique survey data, we conduct a detailed study of the gender salary gap within economics departments in Japan. Despite the presence of rigid pay scales emphasizing age and experience, there is a 7% gender salary gap after controlling for rank and detailed personal, job, institutional and human capital characteristics. This gender salary gap exists within ranks. We find no gender promotion differences. In addition, we find a concentration of the salary gap in public universities and in research oriented universities. Our results show no evidence that the gender salary gap is reducing over time, and reject the hypothesis that females’ choice between household work and market activities is responsible for the gender salary gap.  相似文献   
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According to recent motor control studies, it is important to know probabilistic structure of his/her own motor errors to choose an optimal motor plan (i.e., where you aim at) to maximise the expected gain. In this study, we questioned if pitching form determines the probabilistic structure of pitching errors in baseball pitchers. Eighteen collegiate baseball pitchers with various pitching forms including right- and left-handed overarm, sidearm and underarm throwers threw 100 pitches aiming at a target located 90 cm above the ground. Two dimensional distribution of pitch location was fitted by using bivariate normal distribution and 95% confidence ellipse was calculated. In order to quantify the pitching form, the direction of the throwing arm trajectory in frontal plane was calculated. The direction of the long axis was dependent on each participant’s pitching form (e.g., right overarm pitchers pitched along a right-up–left-down ellipse and left overarm pitchers pitched along a left-up–right-down ellipse). This was confirmed by circular correlation analysis (P = 0.98). These results suggest that different mechanisms, potentially errors in pitching mechanics and errors in ball release timing, might contribute to errors along the long axis and those along the short axis.  相似文献   
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