排序方式： 共有29条查询结果，搜索用时 15 毫秒
1.
Iron deficiency evolves, slowly through several stages. Early iron deficiency caused a depletion in iron stores as shown by
a reduction in the levels of hepatic non heme iron (44%) in the 7 days old pups born to iron deficient mothers. The hemoglobin
levels and PCV (packed cell volume) were significantly reduced only after the age of three weeks. The activities of GABA (γ-amino
butyric acid) shunt enzymes viz. GDH, GAD and GABA-T (glutamate dehydrogenase, glutamate decarboxylase and GABA-transaminase,
respectively) and GABA content were found to decrease during gestation and/or lactation iron deficiency at 1 week (wk), 2wk,
3wk and 4wk of age in the developing rat brains. However GABA binding showed a significant increase at different age groups.
The iron deficiency during lactational exposure showed significant alteration in most of the parameters only at the age of
3 weeks onwards. On rehabilitation with iron supplemented diet for 2 weeks, these altered parameters could not attain corresponding
control values. A prolonged iron deficiency causing alterations in GABA may lead to neurological and behavioral alterations. 相似文献
2.
Jyoti P. Gurung Moein Navvab Kashani Sanaz Agarwal Gonzalo Peralta Murat Gel Matthew A. B. Baker 《Biomicrofluidics》2021,15(3)
Many motile bacteria are propelled by the rotation of flagellar filaments. This rotation is driven by a membrane protein known as the stator-complex, which drives the rotor of the bacterial flagellar motor. Torque generation is powered in most cases by proton transit through membrane protein complexes known as stators, with the next most common ionic power source being sodium. Sodium-powered stators can be studied through the use of synthetic chimeric stators that combine parts of sodium- and proton-powered stator proteins. The most well studied example is the use of the sodium-powered PomA-PotB chimeric stator unit in the naturally proton-powered Escherichia coli. Here we designed a fluidics system at low cost for rapid prototyping to separate motile and non-motile populations of bacteria while varying the ionic composition of the media and thus the sodium-motive force available to drive this chimeric flagellar motor. We measured separation efficiencies at varying ionic concentrations and confirmed using fluorescence that our device delivered eightfold enrichment of the motile proportion of a mixed population. Furthermore, our results showed that we could select bacteria from reservoirs where sodium was not initially present. Overall, this technique can be used to implement the selection of highly motile fractions from mixed liquid cultures, with applications in directed evolution to investigate the adaptation of motility in bacterial ecosystems. 相似文献
3.
Iron deficiency evolves slowly through several stages. Early iron deficiency caused a depletion in iron stores as shown by
a reduction in the levels of hepatic non-heme iron in the new born of iron deficient mothers. Of particular importance is
the effect on central nervous system, which leads to the defects in the cognition and learning processes in humans. Evidence
is strong that in many under developed countries iron deficiency is the main cause of anaemia and supplementation under trial
conditions may prevent some defects of iron deficiency but not all. 相似文献
4.
Neelima Verma Jyoti chakraverty Pankaj Baweja Alka Girotra Leena Chatterjee Manish Chugh 《Indian journal of clinical biochemistry : IJCB》2017,32(1):117-120
Hyperferritinemia (>10,000 ng/ml) is an important hallmark used as an indicator of infection triggered macrophage activation syndrome leading to hemophagocytic lympho histiocytosis (HLH). Measurement of serum ferritin can be used in diagnosis as well as disease monitoring indicator and prognosis related to HLH, cAPS, sepsis, neoplasm and inflammatory conditions. It is a major contributor to manage critically ill patients as predicting and monitoring indicator. It can be used as acute phase response in conditions of MAS, AOSD, cAPS etc. A case study in our hospital showed extremely high ferritin values along with low hemoglobin, elevated LDH and triglycerides with positive MRSA in sputum culture and macrophage proliferation and hemophagocytosis in the bone marrow examination. Patient showed definite inverse relation with steroid therapy and serum ferritin levels. 相似文献
5.
6.
In search of self-efficacy: development of a new instrument for first year Computer Science students
Jyoti Bhardwaj 《Computer Science Education》2017,27(2):79-99
This study explores the changes in Computer Science (CS) students’ self-efficacy between entering study and the end of first year of university. It aims to give course leaders insights into the everyday challenges that affect students’ academic achievement and persistence into second year. The paper begins by proposing that the way CS is taught, the gender imbalance on CS courses, and the experience of the key transitional year into university might influence CS students’ non-continuation. It adopts an academic buoyancy conceptualisation of resilience. Acknowledging the scarcity of instruments covering CS students’ transition to university, the development of a new 20-item questionnaire is described, based on CS students’ own contributions of the challenges they faced during first year. The instrument is administered twice in one session to the same cohort. Analysis of paired responses indicates a loss of confidence to overcome challenges in most aspects, particularly staying motivated to study. 相似文献
7.
8.
Jyoti Aggarwal Akansha Singh Sanjeev Gupta Rajendra Prasad 《Indian journal of clinical biochemistry : IJCB》2021,36(1):120
Psoriasis is a common and an inflammatory skin disease. Trace elements play an important role in the skin metabolism such as keratinisation and melanin formation as well as immunological and inflammatory reactions. Henceforth, the present study was aimed to evaluate the essential metals with special reference to Cu and Zn. In this study, 72 psoriatic patients and 50 controls were enrolled. On the basis of PASI score psoriatic group comprising of 48 mild and 24 severe psoriatic patients were grouped. The serum trace elements analysis in the subjects revealed that serum Cu levels and Cu/Zn ratio was significantly higher in the psoriatic patients as compared to controls. Interestingly, severity of the psoriasis was well correlated with the serum Cu levels. Taking together, all these findings suggest that Cu may be a major culprit in the pathogenesis as well as in the severity of the disease. 相似文献
9.
The microbicidal capacity of polymorphonuclear (PMN) leukocytes of normal human subjects was evaluated by estimating the release
of lysosomal enzymes from normal cells and cells rendered incapable of ingesting particles by treatment with cytochalasin
B, on exposure to a particulate stimulus-serum treated zymosan (STZ). The release of lysosomal enzymes namely beta-glucuronidase,
lysozyme, acid phosphatase, alkaline phosphatase was found to be 16.28%, 27.84%, 20.54%, 15.40% respectively. The cells rendered
incapable of ingesting particles showed enhanced response. The percentage release of beta-glucuronidase, lysozyme, acid and
alkaline phosphatase was increased to 20.58%, 37.95%, 25.87% and 33.04% respectively. This type of response in cytochalasin
B treated PMN leukocytes is due to the conversion of these cells into “secretory cells”, which release lysosomal enzymes outside
the cell, by the process of reverse endocytosis. 相似文献
10.
Falaq?Naz Smita?Jyoti Rahul Nishat?Akhtar Yasir?Hasan?SiddiqueEmail author 《Indian journal of clinical biochemistry : IJCB》2016,31(3):294-301
The continuous use of synthetic hormones as contraceptive pill or hormonal replacement therapy among women is increasing day by day. The widespread use of different formulations as oral contraceptives by women throughout their reproductive cycle has given rise to a serious concern for studying the effects of oral contraceptives on enzymatic profile and DNA damage in peripheral blood lymphocytes among users. The present study was carried out on women taking oral contraceptives. The study was based on the questionnaire having the information of reproductive history, fasting, age, health, nature of menstrual cycle, bleeding and other disease. The profile of the blood serum enzymes i.e. alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), lactate dehydrogenase (LDH), aminotransferases (SGOT and SGPT), serum proteins (albumin and globulin) and DNA damage in lymphocytes was studied among users and non-users. The results of the present study suggest that OCs not only effects enzymatic activity but also results in DNA damage that may vary with the duration of using oral contraceptives. A significant increase in LDH, GGT, SGPT, SGOT, globulin and decrease in ALP as well as albumin was found among users as compared to non-users. The observed DNA damage was more in users as compared to non-users. Hormonal contraceptives seem to exert DNA damage and also have significant effects on blood serum enzymes. 相似文献