Hyperhomocysteinemia,MMPs and Cochlear Function: A Short Review     

Seema Bhargava  Meghaa Shanta Bhargava  Eishaan Kamta Bhargava  LM Srivastava 《Indian journal of clinical biochemistry : IJCB》2016,31(2):148-151

Hyperhomocysteinemia (HHCY) has been demonstrated to affect cochlear microvasculature as well as cochlear epithelial cells directly, with a resultant alteration of the expression of matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs). Hence, ascertaining the optimum concentration of MMPs and TIMPs in the cochlea could help to inhibit hearing loss due to HHCY by the administration of appropriate MMP inhibitors, Since infections/inflammations as well as ototoxic antibiotics have a similar mechanism of otic pathology, the cochlear damage they cause could also be similarly prevented.  相似文献   

Validity and feasibility of an obstacle course to assess fundamental movement skills in a pre-school setting     

Brooke Klingberg  J. J. A. A. M. Hoeboer  Natasha Schranz  LM Barnett  Sanne I. De Vries 《Journal of sports sciences》2019,37(13):1534-1542

Failure to master age-appropriate fundamental movement skills (FMS) at a young age can limit motor skill competence affecting health. Assessments often have issues with feasibility and implementation in a field setting. As such, the purpose of this study was to investigate the validity and feasibility of the Athletic Skills Track (AST), in a pre-school setting. For the validation study sixty-five 3–6 year old children (25 boys and 40 girls) from five pre-schools across Adelaide, Australia participated. Correlations and linear regression analysis (adjusted for age and gender) were used to investigate the association between the time to complete the AST and the raw score of the Test of Gross Motor Development 2 (TGMD-2). For the feasibility study pre-school staff completed a semi-structured interview regarding the feasibility of the AST. The AST took less than a minute per child and the TGMD-2 around 20 minutes for two children. There was a strong negative correlation (r = ?0.63, p < 0.01) between the AST scores and the TGMD-2 scores. All five staff reported strengths of the AST to be its short administration time, setup and appropriateness. These results suggest that the AST could be a feasible and valid method of FMS assessment in Australian pre-schools.  相似文献   

Library as a Provider of Informational Knowledge in the System of Higher Medical Education     

M. V. Terehova  L. M. Feodorova  A. V. Karpovich 《International Information and Library Review》2003,35(2-4):367

In this report we reveal the role of the Scientific Medical Library of the Siberian State Medical University as an information center for the creation of a unified electronic resource, reflecting contributions of the medical institution libraries in the Tomsk Region. We propose cooperation of medical libraries in the formation of bibliographical and full-text digital collections of medical resources in the Tomsk Region.  相似文献   

Library as a Provider of Informational Knowledge in the System of Higher Medical Education     

M.V Terehova  L.M Feodorova  A.V Karpovich 《International Information and Library Review》2013,45(2-4):367-373

In this report we reveal the role of the Scientific Medical Library of the Siberian State Medical University as an information center for the creation of a unified electronic resource, reflecting contributions of the medical institution libraries in the Tomsk Region. We propose cooperation of medical libraries in the formation of bibliographical and full-text digital collections of medical resources in the Tomsk Region.  相似文献