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Paulo Ricardo Pereira Dos Santos Bruno Remígio Cavalcante Andreya Karolyne Dos Santos Vieira Marcos Duarte Guimarães Antônio Marconi Leandro Da Silva Anderson Da Costa Armstrong 《Journal of sports sciences》2020,38(17):1936-1942
ABSTRACT We performed a randomized, controlled trial to analyse the effects of resistance training (RT) on cognitive and physical function among older adults. Fifty participants (mean age 67 years, ~60% woman) were randomly assigned to an RT program or a control group. Participants allocated to RT performed three sets of 10-15RM in nine exercises, three times per week, for 12-weeks. Control group did not perform any exercise. Variables included cognitive (global and executive function) and physical function (gait, mobility and strength) outcomes. At completion of the intervention, RT was shown to have significantly mitigated the drop in selective attention and conflict resolution performance (Stroop test: -494.6; 95%CI: -883.1; ?106.1) and promoted a significant improvement in working memory (digit span forward: -0.6; 95%CI: ?1.0; ?0.1 and forward minus backward: -0.9; 95% CI: ?1.6; ?0.2) and verbal fluency (animal naming: +1.4, 95%CI 0.3, 2.5). No significant between-group differences were observed for other cognitive outcomes. Regarding physical function, at completion of the intervention, the RT group demonstrated improved fast-pace gait performance (?0.3; 95% CI: ?0.6; ?0.0) and 1-RM (+21.4 kg; 95%CI: 16.6; 26.2). No significant between-group differences were observed for other mobility-related outcomes. In conclusion, RT improves cognitive and physical function of older adults. 相似文献
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Juliana FELGUEIRAS Joana Vieira SILVA Margarida FARDILHA 《Journal of Zhejiang University. Science. B》2014,(1)
研究目的:这篇综述系统地阐述了前列腺癌的发生、发展、相关分子信号通路以及分子标志物用于前列腺癌的临床诊断和前列腺癌诊治所面临的挑战。重要结论:许多分子信号通路通过影响细胞生长、凋亡、血管生成等病理生理过程而参与了前列腺癌的起始、发生和发展。这些研究基础有助于寻找前列腺癌的肿瘤标志物和改进前列腺癌的治疗。虽然去势治疗是早期前列腺癌治疗的金标准,但是晚期的激素抵抗型前列腺癌(CRPC)的治疗仍面临着巨大的挑战。所幸的是,目前研究发现可以通过切断特异的蛋白-蛋白相互作用或者通过调节某些影响肿瘤生长和转移的关键分子来治疗前列腺癌,能减少传统治疗所带来的副作用;相关临床研究已开始实施。这些研究进展给前列腺癌的诊治带来了新的曙光。 相似文献
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Silva DA Benedetti TR Ferrari EP Meurer ST Antes DL Silva AM Santos DA Matias CN Sardinha LB Vieira F Petroski EL 《Journal of sports sciences》2012,30(5):479-484
The objective of this study was to describe the anthropometric profiles of elite older triathletes participating in the 2009 Ironman Brazil and to compare their somatotype, anthropometric and body composition characteristics with those of elite young triathletes and older non-athletes. The sample consisted of 64 males, divided into three groups: (1) older triathletes (n = 17), (2) young triathletes (n = 24), and (3) older non-athletes (n = 23). Somatotype was analysed according to the Carter and Heath ( 1990 ) method. Body mass index, sum of four skinfolds, percentage body fat, body fat mass, and fat-free mass were also estimated. Older non-athletes had higher endomorphy, sum of four skinfolds, fat percentage, and body fat mass than the athletes. Older athletes who participated in the Ironman and elite young triathletes had higher fat-free mass than older non-athletes. Older triathletes and older non-athletes were considered mainly endomorphic mesomorphs and young triathletes mainly ectomorphic mesomorphs. The findings that characterize the anthropometric profile of athletes in this sports modality could be used as a reference. 相似文献
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This paper introduces a new impact indicator for the research effort of a university, nh3. The number of documents or the number of citations obtained by an institution are used frequently in international ranking of institutions. However, these are very dependent on the size and this is inducing mergers with the apparent sole goal of improving the research ranking. The alternative is to use the ratio of the two measures, the mean citation rate, that is size independent but it has been shown to fluctuate along the time as a consequence of its dependence on a very small number of documents with an extremely good citation performance. In the last few years, the popularity of the Hirsch index as an indicator of the research performance of individual researchers led to its application to journals and institutions. However, the original aim of this h index of giving a mixed measure of the number of documents published and their impact as measured by the citations collected along the time is totally undesirable for institutions as the overall size may be considered irrelevant for the impact evaluation of research. Furthermore, the h index when applied to institutions tends to retain a very small number of documents making all other research production irrelevant for this indicator. The nh3 index proposed here is designed to measure solely the impact of research in a way that is independent of the size of the institution and is made relatively stable by making a 20-year estimate of the citations of the documents produced in a single year. 相似文献
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Mikhail Santos Cerqueira Jose Diego Sales Do Nascimento Daniel Germano Maciel Jean Artur Mendonca Barboza Wouber Herickson De Brito Vieira 《运动与健康科学(英文)》2020,9(2):152-159
Purpose:To investigate whether blood flow restriction(BFR) without concomitant exercise mitigated strength reduction and atrophy of thigh muscles in subjects under immobilization for lower limbs.Methods:The following databases were searched:PubMed,CINAHL,PEDro,Web of Science,Central,and Scopus.Results:The search identified 3 eligible studies,and the total sample in the identified studies consisted of 38 participants.Isokinetic and isometric torque of the knee flexors and extensors was examined in 2 studies.Cross-sectional area of thigh muscles was evaluated in 1 study,and thigh girth was measured in 2 studies.The BFR protocol was 5 sets of 5 min of occlusion and 3 min of free flow,twice daily for approximately 2 weeks.As a whole,the included studies indicate that BFR without exercise is able to minimize strength reduction and muscular atrophy after immobilization.It is crucial to emphasize,however,that the included studies showed a high risk of bias,especially regarding allocation concealment,blinding of outcome assessment,intention-to-treat analyses,and group similarity at baseline.Conclusion:Although potentially useful,the high risk of bias presented by original stodies limits the indication of BFR without concomitant exercise as an effective countermeasure against strength reduction and atrophy mediated by immobilization. 相似文献