Carnosine in health and disease     

Guilherme Giannini Artioli  Craig Sale  Rebecca Louise Jones 《European Journal of Sport Science》2019,19(1):30-39

Abstract

Carnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of research examining the ergogenic effects (or otherwise) of carnosine. More recent research, however, points towards a potential for carnosine to exert a wider range of physiological effects in other tissues, including the brain, heart, pancreas, kidney and cancer cells. Taken together, this is suggestive of a potential for carnosine to have therapeutic benefits in health and disease, although this is by no means without complication. Herein, we will provide a review of the current literature relating to the potential therapeutic effects of carnosine in health and disease.  相似文献   

Children Talking to Learn     

Christine Craig 《Literacy》1994,28(2):2-5

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So many filters, so little time: the development of a search filter appraisal checklist          下载免费PDF全文

Julie Glanville  Sue Bayliss  Andrew Booth  Yenal Dundar  Hasina Fernandes  Nigel David Fleeman  Louise Foster  Cynthia Fraser  Anne Fry-Smith  Su Golder  Carol Lefebvre  Caroline Miller  Suzy Paisley  Liz Payne  Alison Price    Karen Welch 《Medical Library and Historical Journal》2008,96(4):356-361

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Untainted by money     

Loehle C 《New scientist (1971)》1997,155(2095):44

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Learned and professional society libraries and copyright     

Nigel Lees 《Learned Publishing》2004,17(3):189-194

An account is given of the effects of the EU Copyright Directive on the working of the library of a learned society and the changes in practices required to conform with it.  相似文献   

Setting the Students’ Bearings and Balance in Appraisal     

Barbara L. Craig 《Archival Science》2005,5(2-4):391-402

The author, a professor at the University of Toronto, touches briefly on the extensive and rich archival literature that supports the teaching of macroappraisal, but notes that this is not the only educational material she offers her students when teaching appraisal theory. She discusses the usefulness to archivists of literature from the fields of ethnography, organizational knowing, records in history, personal documentary behaviour, memory, and communications, noting that the use of texts from these fields can encourage students to reflect on their own presumptions and to develop a taste for the wide reading and research that must support appraisal.  相似文献   

Conservation Heating 24 Years On     

Nigel Blades  Katy Lithgow  Sarah Staniforth  Bob Hayes 《文物保护研究》2018,63(5):15-21

ABSTRACT

Control of relative humidity (RH) for collections care is challenging in U.K. historic houses because they are often highly ventilated with poor heat retention, a porous building fabric and naturally tend to high (60–80%) RH if unheated. The significance of the building means that large-scale modifications and installation of air handling systems may be unfeasible and undesirable for the conservation of the building. In the late 1980s the National Trust, for English, Wales and Northern Ireland, investigated conservation heating as an RH control method that works with the natural environment of historic buildings, mimicking historic heating and requiring only modification of existing heating services or a light touch installation of new heating systems. The National Trust adopted conservation heating as its preferred method for environmental control in historic buildings from the 1990s. This method was presented at the IIC 1994 Ottawa congress on preventive conservation. Conservation heating has since been adopted by many historic house management organisations, particularly across north-west Europe, where it is well suited to the climate. This paper reviews conservation heating developments implemented by the National Trust since 1994, in response to a changing external context, new knowledge and developments in operational practice.  相似文献   

Using word embeddings in Twitter election classification     

Xiao Yang  Craig Macdonald  Iadh Ounis 《Information Retrieval》2018,21(2-3):183-207

Word embeddings and convolutional neural networks (CNN) have attracted extensive attention in various classification tasks for Twitter, e.g. sentiment classification. However, the effect of the configuration used to generate the word embeddings on the classification performance has not been studied in the existing literature. In this paper, using a Twitter election classification task that aims to detect election-related tweets, we investigate the impact of the background dataset used to train the embedding models, as well as the parameters of the word embedding training process, namely the context window size, the dimensionality and the number of negative samples, on the attained classification performance. By comparing the classification results of word embedding models that have been trained using different background corpora (e.g. Wikipedia articles and Twitter microposts), we show that the background data should align with the Twitter classification dataset both in data type and time period to achieve significantly better performance compared to baselines such as SVM with TF-IDF. Moreover, by evaluating the results of word embedding models trained using various context window sizes and dimensionalities, we find that large context window and dimension sizes are preferable to improve the performance. However, the number of negative samples parameter does not significantly affect the performance of the CNN classifiers. Our experimental results also show that choosing the correct word embedding model for use with CNN leads to statistically significant improvements over various baselines such as random, SVM with TF-IDF and SVM with word embeddings. Finally, for out-of-vocabulary (OOV) words that are not available in the learned word embedding models, we show that a simple OOV strategy to randomly initialise the OOV words without any prior knowledge is sufficient to attain a good classification performance among the current OOV strategies (e.g. a random initialisation using statistics of the pre-trained word embedding models).  相似文献   

Modern dietary guidelines for healthy pregnancy; maximising maternal and foetal outcomes and limiting excessive gestational weight gain     

Kirsty Jayne Elliott-Sale  Ashley Graham  Stephanie Jane Hanley  Sherry Blumenthal  Craig Sale 《European Journal of Sport Science》2019,19(1):62-70

Abstract

Maternal dietary habits influence maternal and foetal health, representing a pathway for intervention to maximise pregnancy outcomes. Advice on energy intake is provided on a trimester basis, with no additional calories required in the first trimester and an additional 340?kcal?d^?1 and 452?kcal?d^?1 needed for the second and third trimesters. Energy intake depends on pre-gravid body mass index (BMI); underweight women are recommended an increase of 150, 200 and 300?kcal?d^?1 during the first, second and third trimester, normal weight women an increase of 0, 350 and 500?kcal?d^?1 and obese women an increase of 0, 450 and 350?kcal?day^?1. The recommendations for carbohydrate and protein intake are 175?g?d^?1 and 0.88–1.1?g?kgBM?d^?1, with no change to fat intake. The number of pre-gravid obese women is rising; therefore, we need to regulate weight in women of childbearing age and limit gestational weight gain to within the recommended ranges [overweight women 6.8–11.3?kg and obese women 5.0–9.1?kg]. This can be achieved using nutritional interventions, as dietary changes have been shown to help with gestational weight management. As pregnancy has been identified as a risk factor for the development of obesity, normal weight women should gain 11.5–16.0?kg during pregnancy. While some research has shown that dietary interventions help to regulate gestational weight gain and promote postpartum weight loss to some extent, future research is needed to provide safe and effective guidelines to maximise these effects, while benefitting maternal and foetal health.  相似文献   

Effects of heat acclimation on hand cooling efficacy following exercise in the heat     

Elizabeth L. Adams  Lesley W. Vandermark  J. Luke Pryor  Riana R. Pryor  Rachel M. VanScoy  Craig R. Denegar 《Journal of sports sciences》2017,35(9):828-834

This study examined the separate and combined effects of heat acclimation and hand cooling on post-exercise cooling rates following bouts of exercise in the heat. Seventeen non-heat acclimated (NHA) males (mean ± SE; age, 23 ± 1 y; mass, 75.30 ± 2.27 kg; maximal oxygen consumption [VO₂ max], 54.1 ± 1.3 ml·kg^?1·min^?1) completed 2 heat stress tests (HST) when NHA, then 10 days of heat acclimation, then 2 HST once heat acclimated (HA) in an environmental chamber (40°C; 40%RH). HSTs were 2 60-min bouts of treadmill exercise (45% VO₂ max; 2% grade) each followed by 10 min of hand cooling (C) or no cooling (NC). Heat acclimation sessions were 90–240 min of treadmill or stationary bike exercise (60–80% VO₂ max). Repeated measures ANOVA with Fishers LSD post hoc (α < 0.05) identified differences. When NHA, C (0.020 ± 0.003°C·min^?1) had a greater cooling rate than NC (0.013 ± 0.003°C·min^?1) (mean difference [95%CI]; 0.007°C [0.001,0.013], P = 0.035). Once HA, C (0.021 ± 0.002°C·min^?1) was similar to NC (0.025 ± 0.002°C·min^?1) (0.004°C [?0.003,0.011], P = 0.216). Hand cooling when HA (0.021 ± 0.002°C·min^?1) was similar to when NHA (0.020 ± 0.003°C·min^?1) (P = 0.77). In conclusion, when NHA, C provided greater cooling rates than NC. Once HA, C and NC provided similar cooling rates.  相似文献