Carnosine in health and disease     

Guilherme Giannini Artioli  Craig Sale  Rebecca Louise Jones 《European Journal of Sport Science》2019,19(1):30-39

Abstract

Carnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of research examining the ergogenic effects (or otherwise) of carnosine. More recent research, however, points towards a potential for carnosine to exert a wider range of physiological effects in other tissues, including the brain, heart, pancreas, kidney and cancer cells. Taken together, this is suggestive of a potential for carnosine to have therapeutic benefits in health and disease, although this is by no means without complication. Herein, we will provide a review of the current literature relating to the potential therapeutic effects of carnosine in health and disease.  相似文献   

Government Research Reports     

Macdonald MR 《Bulletin of the Medical Library Association》1948,36(3):176-177

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Children Talking to Learn     

Christine Craig 《Literacy》1994,28(2):2-5

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Untainted by money     

Loehle C 《New scientist (1971)》1997,155(2095):44

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Setting the Students’ Bearings and Balance in Appraisal     

Barbara L. Craig 《Archival Science》2005,5(2-4):391-402

The author, a professor at the University of Toronto, touches briefly on the extensive and rich archival literature that supports the teaching of macroappraisal, but notes that this is not the only educational material she offers her students when teaching appraisal theory. She discusses the usefulness to archivists of literature from the fields of ethnography, organizational knowing, records in history, personal documentary behaviour, memory, and communications, noting that the use of texts from these fields can encourage students to reflect on their own presumptions and to develop a taste for the wide reading and research that must support appraisal.  相似文献   

Using word embeddings in Twitter election classification     

Xiao Yang  Craig Macdonald  Iadh Ounis 《Information Retrieval》2018,21(2-3):183-207

Word embeddings and convolutional neural networks (CNN) have attracted extensive attention in various classification tasks for Twitter, e.g. sentiment classification. However, the effect of the configuration used to generate the word embeddings on the classification performance has not been studied in the existing literature. In this paper, using a Twitter election classification task that aims to detect election-related tweets, we investigate the impact of the background dataset used to train the embedding models, as well as the parameters of the word embedding training process, namely the context window size, the dimensionality and the number of negative samples, on the attained classification performance. By comparing the classification results of word embedding models that have been trained using different background corpora (e.g. Wikipedia articles and Twitter microposts), we show that the background data should align with the Twitter classification dataset both in data type and time period to achieve significantly better performance compared to baselines such as SVM with TF-IDF. Moreover, by evaluating the results of word embedding models trained using various context window sizes and dimensionalities, we find that large context window and dimension sizes are preferable to improve the performance. However, the number of negative samples parameter does not significantly affect the performance of the CNN classifiers. Our experimental results also show that choosing the correct word embedding model for use with CNN leads to statistically significant improvements over various baselines such as random, SVM with TF-IDF and SVM with word embeddings. Finally, for out-of-vocabulary (OOV) words that are not available in the learned word embedding models, we show that a simple OOV strategy to randomly initialise the OOV words without any prior knowledge is sufficient to attain a good classification performance among the current OOV strategies (e.g. a random initialisation using statistics of the pre-trained word embedding models).  相似文献   

Modern dietary guidelines for healthy pregnancy; maximising maternal and foetal outcomes and limiting excessive gestational weight gain     

Kirsty Jayne Elliott-Sale  Ashley Graham  Stephanie Jane Hanley  Sherry Blumenthal  Craig Sale 《European Journal of Sport Science》2019,19(1):62-70

Abstract

Maternal dietary habits influence maternal and foetal health, representing a pathway for intervention to maximise pregnancy outcomes. Advice on energy intake is provided on a trimester basis, with no additional calories required in the first trimester and an additional 340?kcal?d^?1 and 452?kcal?d^?1 needed for the second and third trimesters. Energy intake depends on pre-gravid body mass index (BMI); underweight women are recommended an increase of 150, 200 and 300?kcal?d^?1 during the first, second and third trimester, normal weight women an increase of 0, 350 and 500?kcal?d^?1 and obese women an increase of 0, 450 and 350?kcal?day^?1. The recommendations for carbohydrate and protein intake are 175?g?d^?1 and 0.88–1.1?g?kgBM?d^?1, with no change to fat intake. The number of pre-gravid obese women is rising; therefore, we need to regulate weight in women of childbearing age and limit gestational weight gain to within the recommended ranges [overweight women 6.8–11.3?kg and obese women 5.0–9.1?kg]. This can be achieved using nutritional interventions, as dietary changes have been shown to help with gestational weight management. As pregnancy has been identified as a risk factor for the development of obesity, normal weight women should gain 11.5–16.0?kg during pregnancy. While some research has shown that dietary interventions help to regulate gestational weight gain and promote postpartum weight loss to some extent, future research is needed to provide safe and effective guidelines to maximise these effects, while benefitting maternal and foetal health.  相似文献   

Effects of heat acclimation on hand cooling efficacy following exercise in the heat     

Elizabeth L. Adams  Lesley W. Vandermark  J. Luke Pryor  Riana R. Pryor  Rachel M. VanScoy  Craig R. Denegar 《Journal of sports sciences》2017,35(9):828-834

This study examined the separate and combined effects of heat acclimation and hand cooling on post-exercise cooling rates following bouts of exercise in the heat. Seventeen non-heat acclimated (NHA) males (mean ± SE; age, 23 ± 1 y; mass, 75.30 ± 2.27 kg; maximal oxygen consumption [VO₂ max], 54.1 ± 1.3 ml·kg^?1·min^?1) completed 2 heat stress tests (HST) when NHA, then 10 days of heat acclimation, then 2 HST once heat acclimated (HA) in an environmental chamber (40°C; 40%RH). HSTs were 2 60-min bouts of treadmill exercise (45% VO₂ max; 2% grade) each followed by 10 min of hand cooling (C) or no cooling (NC). Heat acclimation sessions were 90–240 min of treadmill or stationary bike exercise (60–80% VO₂ max). Repeated measures ANOVA with Fishers LSD post hoc (α < 0.05) identified differences. When NHA, C (0.020 ± 0.003°C·min^?1) had a greater cooling rate than NC (0.013 ± 0.003°C·min^?1) (mean difference [95%CI]; 0.007°C [0.001,0.013], P = 0.035). Once HA, C (0.021 ± 0.002°C·min^?1) was similar to NC (0.025 ± 0.002°C·min^?1) (0.004°C [?0.003,0.011], P = 0.216). Hand cooling when HA (0.021 ± 0.002°C·min^?1) was similar to when NHA (0.020 ± 0.003°C·min^?1) (P = 0.77). In conclusion, when NHA, C provided greater cooling rates than NC. Once HA, C and NC provided similar cooling rates.  相似文献   

Understanding young Chinese Australian's (dis)engagement in Health and Physical Education and school sport     

Bonnie Pang  Doune Macdonald 《Physical Education & Sport Pedagogy》2016,21(4):441-458

Background: School Health and Physical Education (HPE) and sport has increasingly become a complex cultural contact zone. With global population shifts, schools need policies and strategies to attend to the interests and needs of diverse student populations. School HPE and sport is a particularly significant site as it is a touchpoint for a range of cultural values and practices related to physical activity, the body, health and lifestyle proprieties.

Purpose: While there is a high Chinese student population in Australian schools, little research has been undertaken to understand their needs, experiences and perceptions in schools HPE and sport. In addition, research in the physical activity field is accentuated by paradigms that assume and perpetuate the binary notion of cultural beliefs and practices such as ‘West’ versus ‘East’ and in association with ‘Normal’ versus ‘Problematic’ lifestyles in relation to physical activity. We argue that, without conceding the epistemological understanding of ‘difference’, policies and practices that promote diversity can remain socially unjust and superficial.

Research design: This paper focuses on two schools in Queensland. The data collection process was underpinned by critical and interpretive ethnographic methods. The participants in Sage College consisted of seven girls of whom three were in Year 8, three in Year 9 and one in Year 10. At Routledge State High, a state-owned, secular and coeducational secondary school, the cohort consisted of two girls in Year 8, one girl and two boys from Year 9.

Results: This paper draws on Bourdieu's concepts of habitus, capital, field and doxa and the Chinese Confucianism philosophy of ‘Complementary difference’ to understand the various perceptions and experiences of young Chinese Australians in schools HPE and sport. Results invite us to seek an understanding of students’ subjectivities and disrupt the binary differences in cultural values and attributes to promote multicultural education.

Conclusion and recommendation: Moving beyond the Australia's Anglo-Celtic centred HPE and the limitations of a Western view of exclusive opposites, this paper makes an original contribution to knowledge by presenting a ‘heuristic of difference’ model that accommodates Western and Chinese perspectives in Australian HPE research.  相似文献   

The effects of physical contact type on the internal and external demands during a rugby league match simulation protocol     

Jonathan P. Norris  Jamie Highton  Stephen F. Hughes  Craig Twist 《Journal of sports sciences》2016,34(19):1859-1866

The aim of this study was to investigate how the type of contact influences physiological, perceptual and locomotive load during a simulated rugby league match. Eleven male university rugby league players performed two trials of the rugby league movement simulation protocol for interchange forwards with a traditional soft tackle bag and a weighted tackle sled to replicate contact demands. The interchange forward-specific simulation was chosen given the contact frequency is higher for this group of players compared to whole match players. Locomotive rate, sprint speed, tackle intensity, heart rate (HR) and rating of perceived exertion were analysed during the first and second bouts that replicated two ~23 min on-field passages. Countermovement jump (CMJ) was measured before and immediately after each trial. More time was spent in heart rate zone between 91 and 100% HR_peak during the first (effect size ± 90% confidence interval: 0.44 ± 0.49) and second bouts (0.44 ± 0.43), and larger (0.6 ± 0.69) decrements in CMJ performance were observed during the sled trial (5.9, s = 4.9%) compared to the bag trial (2.6, s = 5.4%). Changing the type of contact during the match simulation subtly altered both the internal and external loads on participants. Using a standard tackle bag results in faster sprint speed to contact, but lower overall high-intensity running. Conversely, a heavier tackle object increases the internal load and results in greater lower limb neuromuscular fatigue as reflected by the decrease in CMJ performance.  相似文献