High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice     

Xiaochuan Zhang  Xianzhen Yin  Jingjing Zhang  Anan Li  Hui Gong  Qingming Luo  Haiyan Zhang  Zhaobing Gao  Hualiang Jiang 《国家科学评论(英文版)》2019,6(6):1223

Accumulating evidence indicates the critical importance of cerebrovascular dysfunction in the pathogenesis of Alzheimer''s disease (AD). However, systematic comparative studies on the precise brain vasculature of wild-type and AD model mice are still rare. Using an image-optimization method for analysing Micro-Optical Sectioning Tomography (MOST) data, we generated cross-scale whole-brain 3D atlases that cover the entire vascular system from large vessels down to smallest capillaries at submicron resolution, for both wild-type mice and a transgenic (APP/PS1) mouse model of AD. In addition to distinct vascular patterns in different brain regions, we found that the main vessels of the molecular layer of the hippocampal dentate gyrus (DG-ml) undergo abrupt changes in both diameter and branch angle, spreading a unique comb-like pattern of capillaries. By using a quantitative analysis workflow, we identified in the hippocampus of AD mice an overall reduction of the mean vascular diameter, volume fraction and branch angle, with most significant impairment in the DG-ml. In addition, virtual endoscopy revealed irregular morphological features in the vessel lumen of the AD mice, potentially contributing to the impairment of blood flow. Our results demonstrate the capability of high-resolution cross-scale evaluation of brain vasculature and underscore the importance of studying hippocampal microcirculation for understanding AD pathogenesis.  相似文献   

苏北高职院校体育教学改革实施中教师阻抗的现象学分析及消除策略     

姜龙  秦博  骆勇 《体育科技文献通报》2020,(4):26-27,31

本文将教师阻抗定义为由于自身或外界因素导致教师对现有体育教学改革表现出的不满、反对、甚至抵制心理和行为。研究以教师阻抗为问题切入点,重点探究教师阻抗的内在原因。具体分析内容包括:现有体育教学改革实施现状、体育教师态度真相、冷落改革,阻抗缘由,并结合阻抗缘由提供相关消解建议。本研究主要以现象学研究方法作为方法论基础,由悬置与还原、体验与描述、反思与归纳、本质的呈现作为重点环节,参照Pollio的现象学研究方法流程,采用深度访谈,访谈对象20人,每轮访谈结束后及时将访谈录音转录为文本形式,访谈文本132571字。对访谈文本采取归纳与演绎相结合的形式,精简提炼并进行具体论证分析。结论:(1)高职院校体育改革情况并不理想,阻抗现象真实存在;(2)体育教师内心支持改革,主观排斥现象罕见,阻抗现象另有他因;(3)体育教师阻抗主要由于教师对公共体育课程教学指导纲要无从下手,各校围绕体育教学改革中需要变更新的大纲、教学方法、评价方式等工作茫然无措所导致。以此建议多安排一线教师参加培训学习;制定更为客观、易操作的教学方法和评价方式应用于高职院校体育教学一线;增大资金及人力投入;提高教师文化自信等方面,消除改革中出现的部分教师阻抗,也为高职体育改革提出一些思路。  相似文献   

Understanding the relative contribution of technical and tactical performance to match outcome in Australian Football     

Christopher M Young  Wei Luo  Paul B Gastin  Daniel B Dwyer 《Journal of sports sciences》2020,38(6):676-681

ABSTRACT

The aim of this study was to assess if tactical and technical performance indicators (PIs) could be used in combination to model match outcomes in Australian Football (AF). A database of 101 technical PIs and 14 tactical PIs from every match in the 2009–2016 Australian Football League (AFL) seasons was merged. Two outcome measures Win-loss and Score margin were used as dependent variables. The top 45 ranked technical and tactical PIs from a feature selection process were used to model match outcome using decision tree and Generalised Linear Models (GLMs). Of the top 45 selected features, this included seven tactical PIs. The Win-loss-based Decision tree model achieved a classification accuracy of 89.0% and GLM 93.2%. A Score margin-based GLM achieved a root mean squared error (RMSE) of 6.9 points. A combined approach to the classification of match outcomes provided no improvement in model accuracy compared with previous literature. However, this study has established the relative importance of technical and tactical measures of performance in relation to successful team performance in AF.  相似文献   

专利被引频次的时间影响研究     

罗文馨  赵亚娟 《图书情报工作》2019,63(9):47-60

[目的/意义]研究时间因素对专利被引频次的影响,可以减少时间因素对技术评价活动的制约,提高评价的准确性和可信度。[方法/过程]采集1975-2017年的美国专利数据,开展基于固定效应法的专利被引频次的修正研究。将专利按照不同公开年份和不同技术领域分组,选定组内均值和6个TOP分位数为被引频次基准,统计当前时间点的被引频次基准线及基准线的历史时序变化情况。建立神经网络模型,拟合基准线的时序变化规律,并预测未来统计时间点的基准线。[结果/结论]专利公开年份和统计年份的时间差异,使得专利被引频次无法直接进行比较。本文建立了基于不同技术领域、不同公开年份和不同统计年份的专利被引频次基准线,为专利评估提供参考。  相似文献   

工作资源对高校图书馆员敬业度影响机制的实证研究     

康超群  杨晴 《图书情报工作》2019,63(17):69-76

[目的/意义]探讨工作资源对高校图书馆员敬业度的影响与机制，以期为高校图书馆实施人力资源管理和提升图书馆员的敬业度提供参考。[方法/过程]选取湖南各高校图书馆的358名馆员为研究对象，考察工作资源对高校图书馆员敬业度的预测作用以及心理资本与组织承诺在两者之间的中介作用。[结果/结论]描述性统计与差异分析、相关分析和逐步回归分析的结果表明，不同性别的高校图书馆员在组织承诺量表得分上存在显著性差异，男性馆员组织承诺得分显著高于女性，不同性别馆员在其余得分上均不存在显著性差异。不同婚姻、年龄、学历、职位、职称者在各量表得分上均不存在显著性差异。高校图书馆员工作资源、心理资本、组织承诺与敬业度的两两相关都达到统计显著性水平。工作资源对高校图书馆员的敬业度具有正向预测作用，心理资本和组织承诺能够在工作资源对高校图书馆员敬业度的影响中起部分中介作用。丰富高校图书馆员工作资源，增进其组织支持感，增强其心理资本和组织承诺，是促进高校图书馆员敬业度提升的有效路径。  相似文献   

股权结构、研发投入与企业经营绩效关系研究     

谭庆  吴铖铖  吴自爱 《保定学院学报》2020,(2):46-51

以我国316家信息技术业上市公司2014—2018年面板数据作为研究对象,通过运用多元线性回归和调节效应检验研究研发投入与经营绩效的关系及股权结构在二者关系间的调节作用。研究结果表明:第一,研发投入与企业经营绩效正相关,且研发人员投入对企业经营绩效的影响高于研发资金投入;第二,股权集中度、股权制衡度均与企业经营绩效正相关。因此,信息技术企业在提高研发创新能力时不仅需要足够的资金保障,更需要充足的智力支持,且适度提高股权集中度、股权制衡度可在一定程度上提高企业经营绩效。  相似文献   

高校篮球运动员专项体能特征分析研究     

金彬彬  陈清 《体育科技文献通报》2020,(4):171-171,175

在篮球运动当中,专项体能培养是帮助运动员熟练掌握篮球技能并进行实战应用的重要条件。文章采用文献资料等,根据分析高校篮球运动员的专项体能的特征,提出了有效培养高校篮球运动员的专项体能训练的手段与办法,旨为进一步推进高校篮球专项体能训练的发展。  相似文献   

Precision measurement of the Newtonian gravitational constant     

Chao Xue  Jian-Ping Liu  Qing Li  Jun-Fei Wu  Shan-Qing Yang  Qi Liu  Cheng-Gang Shao  Liang-Cheng Tu  Zhong-Kun Hu  Jun Luo 《国家科学评论(英文版)》2020,7(12):1803

The Newtonian gravitational constant G, which is one of the most important fundamental physical constants in nature, plays a significant role in the fields of theoretical physics, geophysics, astrophysics and astronomy. Although G was the first physical constant to be introduced in the history of science, it is considered to be one of the most difficult to measure accurately so far. Over the past two decades, eleven precision measurements of the gravitational constant have been performed, and the latest recommended value for G published by the Committee on Data for Science and Technology (CODATA) is (6.674 08 ± 0.000 31) × 10⁻¹¹ m³ kg⁻¹ s⁻² with a relative uncertainty of 47 parts per million. This uncertainty is the smallest compared with previous CODATA recommended values of G; however, it remains a relatively large uncertainty among other fundamental physical constants. In this paper we briefly review the history of the G measurement, and introduce eleven values of G adopted in CODATA 2014 after 2000 and our latest two values published in 2018 using two independent methods.  相似文献   

我国科学家在地球大气涡旋自组织的研究领域取得重要进展     

罗云峰  周小刚 《中国科学基金》2007,21(4):229-230

地球大气中存在大小不等的涡旋,大涡如台风,其半径一般为几百公里,小涡如强对流云团,半径约为几十公里或更小。这些大小不等涡旋之间的相互作用往往不仅导致台风运动的反常以及台风和中、小尺度高影响灾害性天气预报的失败,而且历来是台风和中、小尺度强灾害性天气预测理论的一个关键问题,也是世界各国科学家共同面对的科学前沿和难点问题。  相似文献   

信息产业发展的三大规律与启示     

罗曼 《情报科学》1994,15(4):26-29

本文分析了信息产业发展的三大规律,即信息产业比重增大规律、信息产业结构高度化规律和信息商品价格总水平上升规律,并指出了这三大规律对我们的启示。  相似文献