Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Digital Module 05: Diagnostic Measurement—The G‐DINA Framework https://ncme.elevate.commpartners.com     

Wenchao Ma  Jimmy de la Torre 《Educational Measurement》2019,38(2):114-115

In this ITEMS module, we introduce the generalized deterministic inputs, noisy “and” gate (G‐DINA) model, which is a general framework for specifying, estimating, and evaluating a wide variety of cognitive diagnosis models. The module contains a nontechnical introduction to diagnostic measurement, an introductory overview of the G‐DINA model, as well as common special cases, and a review of model‐data fit evaluation practices within this framework. We use the flexible GDINA R package, which is available for free within the R environment and provides a user‐friendly graphical interface in addition to the code‐driven layer. The digital module also contains videos of worked examples, solutions to data activity questions, curated resources, a glossary, and quizzes with diagnostic feedback.  相似文献   

帆板实际航行中运动学参数的测定     

柏开祥  王德恂  韩久瑞 《武汉体育学院学报》2006,40(2):43-46

对帆板运动进行三维解析即可有效地分析运动员的操作技能，也可利用测定的运动学参数反过来计算与检验空气动力学参数与水动力学参数。介绍了帆板运动的运动学参数、测定的方法。分析了帆板运动学参数测试的可行性。  相似文献   

园林景观动画设计初探     

杨琴 《四川工程职业技术学院学报》2006,(1):98-101,95

本文通过对计算机三维动画的相关理论与技术的初步探讨，并结合环境景观动画的制作实例，介绍了该技术在园林景观动画设计方面的应用和发展前景。  相似文献   

邢傲伟跳马侧手翻直体侧空翻转体810°的运动学分析   总被引：7，自引：3，他引：4  

姚侠文  李吉  李翠玲  于晖  李伟 《北京体育大学学报》2004,27(3):402-404

通过运动学等研究方法,揭示了我国优秀运动员邢傲伟完成的跳马侧手翻直体侧空翻转体810°的运动学规律与技术特点,对于进一步发展笠松类高难动作,提高我国男女跳马技术水平有促进作用.  相似文献   

杨亚红和王湉湉跳马前手翻直体前空翻转体540°的三维运动学分析     

徐华  薛晶  杜传喜 《北京体育大学学报》2004,27(5):714-715

运用三维运动学法对中国体操女子集训队员--杨亚红和王湉湉的跳马前手翻直体前空翻转体540°的动作进行了对比性技术分析,并针对二人动作完成的情况进行了技术性诊断.以期对我国跳马前手翻直体前空翻转体540°动作的训练和技术改进提供参考依据.  相似文献   

Study of transport behavior for Fe-doping La_(0.67)Ca_(0.33)MnO_3 perovskite manganese     

《Journal of Zhejiang University. Science. B》2004,(5)

  相似文献   

2003年12月MP3播放器市场用户喜爱度和价格分析报告     

王皓 《济宁师范专科学校学报》2004,25(6):21-24

通过对ZOL数据中心提供的数据，主要对国内MP3市场品牌、消费者对产品的关注程度及产品的价格走向等问题进行了分析，从而为厂家和消费者提供参考依据。  相似文献   

党的三代领导集体对执政党自身建设的探索与实践     

党玲  曲少杰 《天水师范学院学报》2001,21(3):17-20

新中国成立以来,党的三代领导集体对执政党的自身建设进行了不懈的探索,取得了丰硕成果.  相似文献   

中国北方汉族青年ACE 基因I/ D多态性频率分布特征     

席翼  张秀丽  胡扬  刘刚  包大鹏  张海霞  吴建 《天津体育学院学报》2006,21(3):205-208

通过分析与探讨汉族普通人群ACE基因I／D多态频率分布特征，试图为中国优秀耐力运动员的基因选材研究提供中国人相关人群ACE基因I／D多态频率分布的基础数据。选择18-22岁汉族学生216名作为研究对象，观察其ACE基因I／D多态频率分布。结果显示：北方汉族青年的ACE基因I／D多态频率分布，与国内相关研究结果一致，与欧美人群有非常显著差异。研究认为：从种族单一性、样本数量和年龄段的选择等因素考虑．研究结果不仅可以作为北方汉族青年ACE基因I／D多态频率分布的代表，而且对于杰出耐力的多态性标记研究来讲是理想的对照群体。  相似文献