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目的：观察戊四氮（PTZ）致痫大鼠海马神经元caspase-3表达以及中药复方AAP的脑保护作用.方法：144只健康成年雄性Wistar大鼠随机分为对照组（CK组）、模型组（PTZ组）、中药大剂量组（AAPl组）、中药中剂量组（AAPm组）、中药小剂量组（AAPs组）和丙戊酸钠组（VPA组）;每组各6只.CK组和PTZ组分别给予生理盐水（4mL/kg.d）灌胃;中药各组分别给予中药复方大、中、小剂量（10.26g/kg、5.13g/kg、2.56g/kg）灌胃,每天1次;VPA组腹腔注射VPA（20mg/kg.d）.造模第一天,除CK组外,其余各组大鼠均腹腔注射戊四氮（PTZ）75mg/kg,观察记录大鼠行为学变化;于致痫后12h、2d、5d、7d相应时间点取材,制备脑标本;免疫组化检测caspase-3表达.结果：致痫后,除CK组外,其余各组海马区caspase-3阳性表达增强;7天,与PTZ组相比,AAPl组、AAPm组和AAPs组海马CA3区caspase-3阳性表达减弱（P〈0.05）.结论：caspase-3参与致痫大鼠海马神经元凋亡过程;AAP能降低caspase-3表达,减少神经元凋亡,有神经保护作用. 相似文献
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Munjal M. Acharya Surbhi H. Khamesra Surendra S. Katyare 《Indian journal of clinical biochemistry : IJCB》2005,20(1):56-60
The effect of picrotoxin-induced convulsions on lysosomal function in rat brain were evaluated by measuring the free as well
as total acid phosphatase, cathepsin D, acid ribonuclease (RNAse II) and acid deoxyribonuclease (DNAse II) activities. Following
picrotoxin treatment the free RNAse II activity increased whereas the total activities of practically all the other enzymes
decreased. Paradoxically, the cathepsin D activity, free as well the total was completely abolished. In case of all the enzymes
the ratio of Total activity/Free activity decreased indicating increased lysosomal membrane fragility which could lead to
process of neurodegeneration in the epileptic animals. 相似文献
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癫痫是大脑神经元过度放电而导致的一种大脑功能障碍性疾病,癫痫发作对大脑的损害是不可逆的.目前,针对癫痫常用的几种非线性动力学分析方法包括相关维数,Lyapunov指数,复杂度等.这些方法可有效分析癫痫患者的脑电信号,对治疗癫痫具有重要临床价值. 相似文献
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Feng ZY Zheng XJ Tian C Wang Y Xing HY 《Journal of Zhejiang University. Science. B》2011,12(9):704-711
Dysfunction of inhibitory synaptic transmission can destroy the balance between excitatory and inhibitory synaptic inputs
in neurons, thereby inducing epileptic activity. The aim of the paper is to investigate the effects of successive excitatory
inputs on the epileptic activity induced in the absence of inhibitions. Paired-pulse orthodromic and antidromic stimulations
were used to test the changes in the evoked responses in the hippocampus. Picrotoxin (PTX), γ-aminobutyric acid (GABA) type
A (GABAA) receptor antagonist, was added to block the inhibitory synaptic transmission and to establish the epileptic model. Extracellular
evoked population spike (PS) was recorded in the CA1 region of the hippocampus. The results showed that the application of
PTX induced a biphasic change in the paired-pulse ratio of PS amplitude. A short latency increase of the second PS (PS2) was
later followed by a reappearance of PS2 depression. This type of depression was observed in both orthodromic and antidromic
paired-pulse responses, whereas the GABAergic PS2 depression [called paired-pulse depression (PPD)] during baseline recordings
only appeared in orthodromic-evoked responses. In addition, the depression duration at approximately 100 ms was consistent
with a relative silent period observed within spontaneous burst discharges induced by prolonged application of PTX. In conclusion,
the neurons may ignore the excitatory inputs and intrinsically generate bursts during epileptic activity. The depolarization
block could be the mechanisms underlying the PPD in the absence of GABAA inhibitions. The distinct neuronal responses to stimulations during different epileptic stages may implicate the different
antiepileptic effects of electrical stimulation. 相似文献
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王益明 《金华职业技术学院学报》2001,1(3):52-53
目的探讨癫痫发病与弓形虫感染的关系。方法用ELISA法检测癫痫患者(患者组)28例和健康人(对照组)46例的血清弓形虫IgG、IgM抗体及循环抗原(CAg),阳性者为弓形虫感染。结果患者组弓形虫感染率为21.43%,其中1例儿童患者IgG和IgM抗体双阳性;对照组仅检出IgG抗体,感染率为26.09%,两组中CAg均未检出。两组感染率比较无显著性差异(P>0.05)。结论癫痫的发病与弓形虫感染的关系不大,但少数癫痫患者需排除弓形虫脑病。 相似文献
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