Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Digital Module 05: Diagnostic Measurement—The G‐DINA Framework https://ncme.elevate.commpartners.com     

Wenchao Ma  Jimmy de la Torre 《Educational Measurement》2019,38(2):114-115

In this ITEMS module, we introduce the generalized deterministic inputs, noisy “and” gate (G‐DINA) model, which is a general framework for specifying, estimating, and evaluating a wide variety of cognitive diagnosis models. The module contains a nontechnical introduction to diagnostic measurement, an introductory overview of the G‐DINA model, as well as common special cases, and a review of model‐data fit evaluation practices within this framework. We use the flexible GDINA R package, which is available for free within the R environment and provides a user‐friendly graphical interface in addition to the code‐driven layer. The digital module also contains videos of worked examples, solutions to data activity questions, curated resources, a glossary, and quizzes with diagnostic feedback.  相似文献   

Study of transport behavior for Fe-doping La_(0.67)Ca_(0.33)MnO_3 perovskite manganese     

《Journal of Zhejiang University. Science. B》2004,(5)

  相似文献   

齐海峰竞技成绩的灰色关联分析及GM(1,N)动态协调模型的研究     

孙俊生 《首都体育学院学报》2004,16(1):120-122

采用文献资料法和灰色关联度分析法,对我国优秀男子十项全能运动员齐海峰1999-2002年十项全能的比赛成绩进行统计与分析,运用GM(1,N)动态协调模型对其在总成绩不断提高的各个阶段诸因素间相互联系、相互影响的辩证发展关系进行多方位、多层次研究。结果表明:100米跑、铅球和跳远是影响齐海峰专项成绩的关键因素,其关联度分别为0.8928、0.7443和0.7571,研究还发现,齐海峰在成绩提高的每一个阶段中,系统处于不稳定和非协调发展,其中速度和速度——力量性项目落后是导致系统不稳定和非协调发展的主要因素。  相似文献   

二次曲线的三种分类方法分析   总被引：1，自引：0，他引：1  

马世祥 《天水师范学院学报》2003,23(5):6-7

分析了二次曲线在仿射几何、射影几何和欧氏几何中的分类方法，给出了3种方法之间的联系与区别。  相似文献   

“囚久羊里”,“演《周易》”——关中第一思想家姬昌     

秦草 《西安文理学院学报》2001,(2)

本文从史实出发 ,考察了周文王姬昌“演《周易》”的历史过程及其在思想文化方面的重大贡献  相似文献   

首尾和r-循环矩阵的逆与广义逆的快速算法     

许乃武 《扬州教育学院学报》2006,24(3):32-35

利用多项式的快速算法,给出了求首尾和r-循环矩阵的逆、{1,2}———逆、Drain逆的快速算法.  相似文献   

国内外1975～1991年间关于中小企业信息管理的研究成果统计分析及建议     

冷伏海  冯路 《中国图书馆学报》2002,28(1)

对 1975～ 1991年间国内外有关中小企业研究的文章从关键词分布、主题分布、国家分布等方面进行了统计 ,具体分析了文章主题的内容 ,进而指出我国在这些方面亟待解决与完善的问题 ,对我国支撑中小企业的信息管理提出参考性建议。表 4 ,参考文献 8。  相似文献   

优秀运动员齐海峰竞技成绩的灰色关联分析及其模式训练研究     

王麒麟  程晖  张亚平 《吉林体育学院学报》2006,22(2):57-58,62

运用文献资料法和数理统计分析方法，对我国优秀男子十项全能运动齐海峰近几年的比赛成绩进行了综合分析，找出了影响其专项成绩的主要因素，并在此基础上，运用CM（1，N）动态协调模型对其在总成绩不断提高的过程中，系统处于不稳定和非协调发展局势，进行了多方位，多层次的研究，旨在对其成绩的提高起到借鉴作用。  相似文献   

丁胱亚磺酰亚胺排空组织谷胱甘肽对大鼠心肌c-jun、c-fos mRNA的影响     

毛丽娟 《武汉体育学院学报》2005,39(10):46-49

设计三种实验模型,即力竭游泳运动模型、递增负荷游泳训练模型、BSO排空GSH模型,研究三种模型对大鼠心肌中原癌基因c-jun和c-fos mRNA表达的影响。结果发现力竭运动后训练力竭组、注射BSO力竭组、对照力竭组的大鼠心肌中c-jun mRNA表达量与相对应的训练安静组、注射BSO、对照安静组均增加,大鼠心肌中c-fos安静组mRNA表达量增加。BSO力竭组的c-fos mRNA表达量高于对照力竭组。训练力竭组与对照力竭组相比c-fos mRNA表达量没有明显变化。由上述实验结果推出,长时间力竭运动机体活性氧产生增加,c-jun mRNA和c-fos mRNA的表达量增加,进而激活转录因子AP-1。  相似文献