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Hayriye Senturk Ciftci Tulay Kilicaslan Ayna Yasar Kerem Calıskan Aydin Turkmen Mehmet Gurtekin 《Indian journal of clinical biochemistry : IJCB》2013,28(2):164-168
The calcineurin inhibitors (CNIs) [cyclosporin A (CsA) and tacrolimus (Tac)] are currently the most widely prescribed drugs for maintenance of immunosuppression after renal transplantation. These immunosuppressants are associated with side effects such as hyperlipidemia. We evaluated the differential effects of different CNIs on serum lipid parameters in renal transplant patients. Moreover, the aim of this study is to investigate the relationships between doses and blood levels of CNIs, and blood levels of CNIs and lipid parameters retrospectively. Two groups of 98 non-diabetic renal transplant patients, each treated with different CNIs, were studied: group A (n = 50, mean age: 31 ± 10 years), CsA, mycophenolate mofetil/azathioprin, steroid; group B (I = 48, mean age: 34 ± 12 years), Tac, mycophenolate mofetil/azathioprin, steroid. In renal transplant patients, CNIs blood levels and doses were examined at 1, 3, 6, 9, and 12 months after transplantation. Biochemical laboratory parameters including plasma lipids [total-cholesterol (CHOL), low-density lipoprotein (LDL)–CHOL, high-density lipoprotein (HDL)–CHOL, and triglycerides (TG)], CNI levels and doses were examined at 1, 3, 6, 9, and 12 months after transplantation. None of the patients received anti-lipidemic drugs during the study period. Blood levels of CNIs were detectable in all whole-blood samples by Cloned- Enzyme-Donor Immunoassay (CEDIA). The relationship between CNIs blood levels and CHOL, (LDL)–CHOL, HDL–CHOL, TG were evaluated. The mean serum CHOL levels and LDL–CHOL levels of patients in group A were found significantly higher than the patients in group B during the 12 month of follow up (p < 0.05). There was no significant difference in TG and HDL–CHOL plasma levels between group A and group B (p > 0.005). In group A the daily dose of CsA was significantly correlated with the mean blood levels of CsA at the 1st and 3rd months (r = 0.387, p = 0.005; r = 0.386, p = 0.006), respectively. In group A, the daily dose of CsA was significantly correlated with the mean serum TG levels during the 12 month of follow up (r = 0.420, p = 0.003). In group B, the daily dose of Tac was significantly correlated with the mean blood level of Tac (r = 0.335, p = 0.020) at the 1st month. No correlation was found between mean Tac blood levels and lipid parameters during the 12-month of follow up (p > 0.05). Significant positive correlation was observed between the CsA blood levels and LDL–CHOL levels (r = 0.338, p = 0.027) at the 3rd month. In the renal transplant patients with well functioning grafts, CsA therapy is associated with increased CHOL and LDL–CHOL ratio which represents an increased atherogenic risk tended to be associated with CsA. Serum LDL–CHOL levels may be effected by blood CsA levels. 相似文献
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INTRODUCTION Left ventricular hypertrophy has been thought to be the principal predicators of predisposing risk factor of cardiac morbidity and mortality (Devereux, 1995; Levy et al., 1990). The pathogenesis that mediates cardiac hypertrophy is poorly understood. Cardiachypertrophy can be induced by hemodynamic over-load, ischemic disease, neurohumoral factors and intrinsic defects in cardiac structural protein genes (Sadoshima and Izumo, 1997; Vikstrom and Lein-wand, 1996). Another in… 相似文献
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T. K. Sankaranarayanan C. Subramanyam 《Indian journal of clinical biochemistry : IJCB》2003,18(1):1-4
A comparative study was conducted to evaluate calcineurin activity in normal pancreatic beta cells and insulinoma cells in
relation to their oxidative state. In comparison to normal islets, insulinoma cells had enhanced oxidative stress as evidenced
by increased content of thiobarbituric acid reactive substances. In addition, diminished activity of calcineurin in insulinoma
cells was concomitant with decreased content of reduced glutathione and glutathione peroxidase activity signifying diminished
antioxidant status in these cells. Culturing insulinoma cells in presence of the calcineurin inhibitor cyclosporin A resulted
in further decrease of calcineurin activity with restoration of glutathione peroxidase but without restoration of reduced
glutathione levels. These results indicate that an estimate of oxidative stress in pancreatic islets and insulinoma cells
can be obtained by assaying calcineurin activity. 相似文献
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Rashmi Choudhary K. P. Mishra C. Subramanyam 《Indian journal of clinical biochemistry : IJCB》2006,21(2):107-113
Recent reports on the involvement of calcineurin in cardiac hypertrophy and its susceptibility to free radicals, prompted
us to examine possible beneficial effects of dietary antioxidants in this regard. In continuation of initialin vitro studies revealing eugenol to be a potent calcineurin inhibitor, we investigated its ability to reverse isoproterenol-induced
cardiac hypertrophy in rats. Intraperitoneal administration of isoproterenol (1 mg/kg body wt/day for 10 days) induced cardiac
hypertrophy with increased heart weight and enhanced apoptosis of myocytes concomitant with accumulation of reactive oxygen
species, decreased glutathione contents, increased activities of calcineurin and protein kinase C in ventricular tissue. Administering
eugenol for 3 days (1 mg/kg body wt/twice a day), followed by combined administration of isoproterenol and eugenol resulted
in significant reversal of cardiac hypertrophy and restoration of above changes. These results suggest that eugenol, a natural
antioxidant of dietary origin, may offer potential benefits in the management of cardiac hypertrophy. 相似文献
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L. Hema Bindu P. Usha Rani P. P. Reddy 《Indian journal of clinical biochemistry : IJCB》2007,22(2):32-35
Calcineurin, a Ca2+—Calmodulin dependent protein phosphatase, is important for Ca2+ mediated signal transduction. The main objective of this study was to examine the potential role of calcineurin in idiopathic
mental handicap. Calcineurin levels were estimated in 20 children in the age group of 5–16 years with idiopathic mental handicap
attending the Special. Education Centre for the Mentally Handicapped in Hyderabad. The results of the present study showed
decreased activity of serum calcineurin in children with idiopathic mental handicap compared to those of normal subjects in
the same age group. The observations thus suggest impaired calcineurin activity in children with mental handicap. Calcineurin
that is involved in biosynthesis and release of neurotransmitters at the synaptic terminal brain is affected thereby causing
brain damage and leading to mental handicap. Impaired calcineurin activity was already indicated in many human diseases such
as Down's syndrome, Alzheimers, Brain ischemia, cardiac hypertrophy etc. It is therefore necessary to check the calcineurin
levels in children with mental handicap to understand the role of calcineurin in the causation of Mental handicap. 相似文献
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目的:探讨子宫平滑肌组织钙调神经磷酸酶(CaN)活性与年龄的关系.方法:应用酶学测定方法,测定了42例大鼠子宫平滑肌组织中CaN的活性.结果:(1)6周、8周、10周和12周大鼠之间子宫平滑肌CaN活性有显著差异(P＜0.01);(2)16周、20周和24周大鼠之间子宫平滑肌CaN活性无显著差异(P＞0.05);(3)6周、8周、10周和12周分别与16周、20周、和24周大鼠之间子宫平滑肌CaN活性有显著差异(P＜0.01).结论:正常雌性大鼠子宫平滑肌组织CaN的活性随年龄增长逐渐增加,到16周后稳定在较高水平. 相似文献
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钙调神经磷酸酶信号转导途径与运动性心肌肥大研究进展 总被引：3，自引：0，他引：3
心脏通过重塑结构和体积应对生理和病理等刺激所造成的不同生理负荷的需求，长期运动训练能促进发生心肌生理性肥大反应但机制仍未阐明。钙离子／钙调素依赖的钙调神经磷酸酶信号转导途径参与心肌肥大反应过程。综述近年来关于钙调神经磷酸酶依赖的信号通路参与心肌肥大调节的分子信号机制，探讨阻止心肌病理生理性肥大的信号传递机制，以期预防运动性心血管疾病的发生。 相似文献
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