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Objective: To investigate the cytokine response pattern (IL-4/IFN-γ) in infants with RSV infections and bronchiolitis during the acute phase. Methods: Four-color flow cytometry was used to measure intracellular IL-4 and IFN-γ expressions in peripheral blood CD3+ and CD8+ lymphocytes from RSV-infected and bronchiolitis infants. Serum IL-4 and IFN-γ levels were also determined. Results: RSV-infected and bronchiolitis infants showed no statistical differences from not-RSV-infected or pneumonia infants and control in the frequency of IL-4 and IFN-γ expressions in CD3+CD8- lymphocytes, showed no obvious Th1/Th2 imbalance, while IFN-γ was expressed much more frequently in CD3+CD8+ lymphocytes. Systematically, RSV-infected and bronchiolitis infants showed much lower levels of serum IL-4 and IL-4/IFN-γ ratios and much higher serum IFN-γ levels than control. However, there were no statistical differences in the above three indices between RSV-infected and not-RSV infected infants or between bronchiolitis and pneumonia infants, except that bronchiolitis infants had a higher level of serum IFN-γ than pneumonia infants statistically. Conclusions: There is no type-2 cytokine response predominance in the acute phase of RSV infection and bronchiolitis. IL-4 production is suppressed and IFN-γ production upregulated, the latter being most prominent in bronchiolitis infants. 相似文献
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Fernando Martínez-Santiago L. Alfonso Ureña-López Maite Martín-Valdivia 《Information Retrieval》2006,9(1):71-93
A usual strategy to implement CLIR (Cross-Language Information Retrieval) systems is the so-called query translation approach.
The user query is translated for each language present in the multilingual collection in order to compute an independent monolingual
information retrieval process per language. Thus, this approach divides documents according to language. In this way, we obtain
as many different collections as languages. After searching in these corpora and obtaining a result list per language, we
must merge them in order to provide a single list of retrieved articles.
In this paper, we propose an approach to obtain a single list of relevant documents for CLIR systems driven by query translation.
This approach, which we call 2-step RSV (RSV: Retrieval Status Value), is based on the re-indexing of the retrieval documents
according to the query vocabulary, and it performs noticeably better than traditional methods.
The proposed method requires query vocabulary alignment: given a word for a given query, we must know the translation or translations
to the other languages. Because this is not always possible, we have researched on a mixed model. This mixed model is applied
in order to deal with queries with partial word-level alignment. The results prove that even in this scenario, 2-step RSV
performs better than traditional merging methods. 相似文献
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