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K Reshma V Rao Ashalatha M Dinesh DM Vasudevan 《Indian journal of clinical biochemistry : IJCB》2005,20(1):160-164
Flavonoids extracted from the leaves of Indian holy basil, Ocimum sanctum showed promising results as radioprotector in rodents.
Hence it was thought pertinent to analyze the antioxidants of erythrocytes in oral cancer patients who were concurrently treated
with radiation and ocimum flavonoids. Oral cancer patients consisted of 2 groups. Group A (n=17) received radiation alone
while Group B(n=17) received radiation and ocimum flavonoids(OF). Samples of heparinised blood were collected prior to treatment,
15 and 30 days respectively after treatment. Blood from normal healthy volunteers were taken as controls (n=25). Erythrocytes
were analyzed for the antioxidants viz. glutathione, glucose 6 phosphate dehydrogenase, glutathione peroxidase and superoxide
dismutase by the standard methods. Results of analysis indicated that erythrocytes from cancer patients (Group A and B) had
significantly high glutathione levels before as well as after treatment compared to controls. It was observed that Group B
which received OF showed a significant reduction in glutathione levels in comparison with Group A. All the other parameters
showed no statistical significant changes. Results of the study suggest that erythrocytes from cancer patients responded to
oxidative stress by elevating glutathione levels, while a decrease in glutathione levels observed in Group B, could be due
to the free radical scavenging effect of OF, sparing the glutathione. However OF did not seem to exert its effect on other
antioxidants of erythrocytes. 相似文献
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K. Reshma A. V. Rao M. Dinesh D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2008,23(2):171-175
Oxidants (NADPH oxidase and myeloperoxidase) and antioxidants (GSH,GSH peroxidase, SOD and glucose 6 phosphate dehydrogenase,
that provides NADPH for antioxidants) were assayed in the neutrophils from oral cancer patients, in three stages viz, baseline
samples,15 days after radiation and 30 days following radiation. These samples were obtained from 2 groups of patients. Group
A that received radiation alone and Group B that received radiation and ocimum flavonoids,a radioprotector. The results showed
a significant fall in the SOD levels in the second follow up of group B.Glucose 6 phosphate dehydrogenase showed significant
increase only in the first follow up of patients who received Ocimum flavonoids. Except for these findings all other parameters
remained statistically nonsignificant. 相似文献
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