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1.
目的：锻炼与针刺组合对退行性膝关节炎微循环血流灌注量的影响。方法：研究对象40例随机分为2组，分别是针刺组（单纯针刺）和锻炼组（站桩与针刺组合），对其实验前后疼痛程度（VAS）、微循环血流灌注量（MBPU）及皮肤温度的变化进行检测分析。结果：两组实验后，VAS评分明显降低（P<0.01），锻炼组优于针刺组（P<0.05）；MBPU降低（P<0.01），锻炼组优于针刺组（P<0.05）；局部温度明显提高（P<0.05）。结论：锻炼与针刺组合可以明显缓解退行性膝关节炎的疼痛症状，降低局部微循环血流灌注量，提高皮肤温度；优于单纯针刺疗法。 相似文献
2.
K. Pratibha T. Seenappa K. Ranganath 《Indian journal of clinical biochemistry : IJCB》2007,22(2):158-161
Alkaptonuria, a metabolic disorder characterized by a triad of homogentisic aciduria, arthritis and ochronosis is one of the
first conditions in the charter of group of inborn errors of metabolism proposed to have Mendelian recessive inheritance.
It is due to the deficiency of the enzyme homogentisic acid oxidase which catalyzes the conversion of homogentisic acid to
maleylacetoacetic acid in the catabolism of tyrosine. Homogentisic acid thus accumulates in cells and body fluids and its
oxidized polymers bind to collagen, leading to progressive deposition of grey to bluish black pigment resulting in degenerative
changes in cartilage, intervertebral disc and other connective tissues, leading to arthritis which is the only disabling effect
in an affected older individual. However the diagnosis can be made in neonates when blackish stain is noticed in an unwashed
diaper. Alkaptonuria is treated symptomatically, surgical intervention necessitates in advanced stages, treatment with ascorbic
acid (Vitamin C) and dietary restrictions of food containing phenylalanine and tyrosine have proved to be successful in alleviating
the symptoms. 相似文献
3.
R. Kumar S. B. Pachori G. K. Senger Satyanand L. D. Joshi 《Indian journal of clinical biochemistry : IJCB》1994,9(2):72-74
Aim of present study was to compare the adenosine deaminase (ADA) activity in various types of arthritis conditions with synovial
effusion. No. significant difference was observed in ADA activity in serum of control and study groups but results have shown
a definite pattern of ADA activity in synovial fluid in various arthritic conditions. The highest value of ADA activity was
observed in synovial fluid of patients with tubercular arthritis followed by rheumatoid, septic, osteo and post traumatic
arthritis. Thus measurement of ADA activity in synovial fluid can be used as a parameter of differential diagnosis of arthritis
specially tubercular in initial stages. 相似文献
4.
刘秀平 《孝感职业技术学院学报》2014,(4):101-105
目的：研究近红外荧光分子探针,Cy5.5葡萄糖胺（Cy5.5-2DG）,能否在活体水平上对小鼠诱导性关节炎（CIA）炎症进行显像。方法：对患有CIA的小鼠注射18F-脱氧葡萄糖（18F-FDG）,1h后,进行Micro PET成像。在18F-FDG放射性衰变以后,通过尾静脉对小鼠注射Cy5.5-2DG。Cy5.5-2DG对关节炎组织的靶向性和保留性通过Xenogen IVIS 200光学成像仪进行评估和量化分析。患病小鼠体内的炎症组织通过18F-FDG-Micro PET扫描清晰可见,从该小鼠体内的Cy5.5-2DG的近红外荧光成像可以看出Cy5.5-2DG在关节组织的分布模式和18F-FDG极其相似;定量分析进一步表明关节炎组织在1 h后对18F-FDG的摄取量和Cy5.5-2DG在不同时刻的摄取量有很好的相关性（r2〉0.65）。结果：18FFDG的摄取量和Cy5.5-2DG累积量之间良好的相关性,为进一步研究Cy5.5-2DG用于评估药物消炎治疗提供了依据。结论：NIRF葡萄糖衍生物Cy5.5-2DG可以检测小鼠手掌的关节炎组织,更重要的是Cy5.5-2DG在关节炎组织中的累积程度与18F-FDG摄取量有很大的正相关。 相似文献
5.
目的:观察健身气功.五禽戏辅助治疗类风湿关节炎患者的疗效。方法:79名实验对象随机分为气功锻炼组和对照组。运动组进行6个月有组织的新编气功.五禽戏健身锻炼。运动强度的确定依据Jungmann公式,每天1次、每次运动40m,对照组不安排运动。结果:与对照组相比,实验组疗效显著率显著高于对照组(P<0.01),各项指标均具有显著性的差异:其中关节肿胀指数(P<0.01)、关节压痛指数(P<0.05)、晨僵时间(P<0.05)、ESR(P<0.05)、CRP(P<0.01)、AST(P<0.01)、ALT(P<0.01)及双手指间关节X线检查骨质破坏发生率%(P<0.05)。结论:健身健身气功.五禽戏对类风湿关节炎性病情有较好的辅助治疗作用,有利于患者的康复。 相似文献
6.
郭友成 《襄樊职业技术学院学报》2013,(3):34-35
目的探讨抗-CCP抗体检测在类风湿关节炎诊断中的作用。方法回顾性分析了125例疑为风湿疾病患者及33例类风湿关节炎（RA）患者抗-CCP抗体和RF检测结果。结果 125例疑为风湿疾病患者中,抗-CCP抗体阳性31例、RF阳性10例,其中确诊的33例RA患者抗-CCP抗体阳性31例、RF阳性9例。结论抗-CCP抗体检测是RA早期诊断一种十分有效的方法。 相似文献
7.
类风湿关节炎（Ｒｈｅｕｍａｔｉｏｄ Ａｒｔｈｒｉｔｉｓ，ＲＡ）是一种原因不明的自身免疫性疾病，致残率高，严重影响病人的生活质量和预期生命，因此一直是世界范围内研究热．近年来由于分子生物学及免疫学的发展，也使风湿病的研究有了很大进展 大量研究表明，细胞因子在ＲＡ免疫反应中起到了重要作用．由此而产生的细胞因子生物治疗不仅为ＲＡ的治疗开辟了新的途径同时也将成为２１世纪的发展趋势． 相似文献
8.
目的为探索RA生物治疗的新途径,以及进一步认识RA的发病机制方法：近交系SD大鼠以完全弗氏佐剂致炎形成佐剂关节炎（adjuvantarthritis,AA）．分离AA大鼠淋巴细胞,经培养扩增后,采用已建立的肿瘤疫苗专利技术制成LAK疫苗．实验动物分别于腋下注射LAK细胞疫苗,每周一次共2次．治疗前后分别采血测定WBC和RBC并作比较分析结果经LAK细胞疫苗免疫后,实验动物组外周血淋巴细胞数目较治疗前显著减少（23.75±9．36对10.82±6,38,p＜0.01）．同时实验动物组的贫血状况明显好转,RBC数量明显增加（6.40±1.67对9.24±2．21,P＜0．05）结论LAK细胞疫苗可降低佐剂关节炎外周血淋巴细胞的数目并改善其贫血状态,在治疗自身免疫性疾病中可能是一种有用的手段,值得进一步研究． 相似文献
9.
Xi Xie Jin-wei Chen Fen Li Jing Tian Jie-sheng Gao David Zhang 《Journal of Zhejiang University. Science. B》2010,11(10):779-782
Psoriatic arthritis (PsA) is a rheumatoid factor (RF)-seronegative systemic inflammatory disorder associated with psoriasis.
Current treatment for PsA in China is still focused on disease modifying anti-rheumatic drugs (DMARDs). In this paper, we
report two Chinese patients with active longstanding PsA treated with infliximab, a human-mouse chimeric monoclonal antibody
against tumor necrosis factor alpha (TNF-α). The results show that infliximab acted quickly and effectively in relieving peripheral
and axial symptoms and refractory skin lesions, even in recombinant human TNF-α receptor (rhTNFR)-resistant case. The take-home
message from our cases is that infliximab is a useful therapeutic option for refractory PsA, especially when a patient has
a combination of psoriasis and psoriatic arthritis. Further local evidence and experience must be accumulated in order to
make anti-TNF-α therapy more accessible to PsA patients in China. 相似文献
10.
D. Vijayakumar K. Suresh S. Manoharan 《Indian journal of clinical biochemistry : IJCB》2005,20(1):52-55
The present study has investigated the levels of lipids, lipoprotein cholesterol (HDL and LDL cholesterol), thiobarbituric
acid reactive substances (TBARS) and vitamin E in plasma and erythrocyte membranes of twenty two clinically diagnosed adult
rheumatoid arthritis patients and an equal number of age matched healthy subjects. The levels of lipids and lipoprotein cholesterol
were markedly reduced in patients with rheumatoid arthritis as compared to healthy subjects. The altered lipid pattern may
be related to decreased lipoprotein cholesterol, fatty acids and impairment in antioxidant defence mechanism. 相似文献