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Banibrata Mukhopadhyay Shashikant Chinchole Valentine Lobo Sishir Gang Mohan Rajapurkar 《Indian journal of clinical biochemistry : IJCB》2004,19(2):14-19
Serum creatinine does not distinguish between various causes of graft dysfunction. Serial assay of proximal tubular enzymes
N-Acetyl-D-glucosaminidase (NAG), Alanine aminopeptidase (AAP) and Gamma glutamyl transferase (GGT) in urine was done to assess
their usefulness in distinguishing various causes of graft dysfunction. Daily serum creatinine and enzymuria were measured
in 32 consecutive renal allograft recipients for first 15 postoperative days. Graft dysfunction was defined as >20% increase
in serum creatinine and >100% increase in enzymuria over the baseline. The diagnosis of graft dysfunction was based upon clinical
criteria, ultrasonography, cyclosporin trough level, allograft biopsy, response to anti-rejection therapy and alteration of
cyclosporin dosage. Fifteen episodes of graft dysfunction were identified in 15 patients. The sensitivity and specificity
of the enzymes (NAG, AAP and GGT) for predicting graft dysfunction were 87.5%, 86.9%, 88.5% and 98.2%, 98.2%, 97.9% respectively.
There was a significant increase in enzymuria during acute tubular necrosis (ATN) and acute rejection episode compared to
cyclosporin nephrotoxicity (p<0.01). Enzymuria assay provides a simple, reliable and noninvasive method to distinguish cyclosporin
nephrotoxicity from acute tubular necrosis and acute rejection in renal allograft recipients. 相似文献
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目的探讨环孢素A（CsA）联合CAG方案治疗骨髓增生异常综合征（MDS）转化的急性白血病的疗效和不良反应。方法对16例MDS/AML患者实施CsA联合CAG方案诱导治疗,1个疗程后评估疗效,无效者退出,有效者继续接受下个疗程治疗。随访分析14例患者生存期,评判CsA联合CAG方案的长期疗效。结果 16例MDS/AML患者,1疗程后4例达CR（25.0%）,6例达PR（37.5%）,4例NR（25.0%）;2疗程CR 43.8%,总有效率62.5%。7例大于≥60岁的老年患者中,2疗程1例达CR（14.3%）,2例达PR（28.6%）,2例NR（28.6%）,2例早期死亡,有效率42.9%。随访14例患者中位生存时间11月,1年、2年的生存率分别为50.0%,21.4%。临床不良反应主要为骨髓抑制,其中中性粒细胞〈0.5×109/L发生率87.5%,PLT〈20×109/L发生率81.3%。结论 CsA联合CAG方案治疗MDS/AML安全有效,疗效较为满意。 相似文献
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目的:探讨应用抗人胸腺球蛋白(ATG)联合环孢素治疗儿童重型再生障碍性贫血的临床护理方法。方法:对15例儿童重型再生障碍性贫血患儿进行治疗前、治疗过程及出院后全面的整体护理。结果:15例病例治愈11例,无效3例,死亡1例,治愈成功率73.3%.结论:加强儿童重型再生障碍性贫血免疫治疗护理,有利于提高疗效,减少并发症发生。 相似文献
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